Increased serum and salivary immunoglobulins against Candida albicans in HIV-infected patients with oral candidiasis.

Abstract

The aim of this study was to explore anti-Candida albicans systemic and mucosal humoral responses against Candida virulence antigens such as somatic antigen and secreted aspartic proteases (Saps) in HIV-infected patients with oral candidiasis. Twenty-eight subjects were included in the study: 11 HIV-positive patients without oral candidiasis (group A), 6 HIV-positive patients with oral candidiasis (group B) and 11 HIV-negative healthy controls (group C). Total IgA, IgG and IgM concentrations and antibodies to C. albicans (somatic antigen, Sap1, Sap6) were measured in serum and saliva. We developed a time-resolved immunofluorometric assay with biotin and europium-labeled streptavidin for this purpose. Salivary total IgA, IgG and IgM concentrations were higher in group B. IgA, IgG and IgM anti-C. albicans antibodies (against somatic antigen, Sap1, Sap6) were higher in saliva and serum from patients from group B compared with patients from group A and controls. Our results suggest that, in oral candidiasis, HIV-infected patients have a high mucosal response, specifically directed against C. albicans virulence antigens, such as somatic antigen, Sap1 and Sap6.

• Authors: C Drobacheff, L Millon, M Monod, R Piarroux, E Robinet, R Laurent, D Meillet
• Journal: Clinical chemistry and laboratory medicine (Clin Chem Lab Med) Vol. 39 Issue 6 Pg. 519-26 (Jun 2001) ISSN: 1434-6621 [Print] Germany
• PMID: 11506465 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)

Chemical References

• Antibodies, Fungal
• Antigens, Fungal
• Immunoglobulin A
• Immunoglobulin A, Secretory
• Immunoglobulin G
• Immunoglobulin M
• Aspartic Acid Endopeptidases

Topics

• AIDS-Related Opportunistic Infections (immunology)
• Adult
• Antibodies, Fungal (blood, metabolism)
• Antigens, Fungal
• Aspartic Acid Endopeptidases (immunology)
• Candida albicans (enzymology, immunology, pathogenicity)
• Candidiasis, Oral (complications, immunology)
• Case-Control Studies
• Female
• HIV Infections (immunology)
• Humans
• Immunity, Mucosal
• Immunoglobulin A (blood)
• Immunoglobulin A, Secretory (metabolism)
• Immunoglobulin G (blood, metabolism)
• Immunoglobulin M (blood, metabolism)
• Male
• Middle Aged
• Saliva (immunology)