Sigma-1 Receptor

01/01/2022 - "Therefore, based on preclinical studies, this review discusses whether the sigma-1 receptor could be a promising target for drugs treating affective and cognitive disorders."
01/01/2023 - "Sigma-1 Receptor as a Protective Factor for Diabetes-Associated Cognitive Dysfunction via Regulating Astrocytic Endoplasmic Reticulum-Mitochondrion Contact and Endoplasmic Reticulum Stress."
01/01/2022 - "Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders."
04/01/2015 - "We assessed sigma-1 receptor expression and memory function in two animal models of cognitive impairment. "
04/01/2015 - "Altered sigma-1 receptor expression in two animal models of cognitive impairment."

04/01/2015 - "Our results demonstrate that DTG, a sigma-1 receptor agonist, reverses some of the behavioral and neuromorphological effects of nVHL on the rat and supports the possibility that DTG may have beneficial effects in the management of symptoms of schizophrenia."
01/01/2014 - "We showed that induction of the sigma-1 receptor plays a role in the UPR, and suggested the possibility that this mechanism is impaired in disorders such as schizophrenia. "
04/30/2009 - "Association between sigma-1 receptor gene polymorphism and prefrontal hemodynamic response induced by cognitive activation in schizophrenia."
01/01/2012 - "In this article, we review the recent findings on sigma-1 receptor agonists as potential therapeutic drugs for the treatment of cognitive impairment in schizophrenia and psychotic depression."
01/01/2004 - "sigma-1 receptor ligands have failed to improve acute psychotic symptoms of schizophrenia in clinical trials, but, interestingly, a few studies have shown an improvement in negative symptoms in schizophrenic patients. "

04/15/2017 - "MicroRNA-297 promotes cardiomyocyte hypertrophy via targeting sigma-1 receptor."
01/01/2013 - "We recently found very high expression of the sigma-1 receptor, an orphan receptor, in rat heart tissue and defined the cardiac sigma-1 receptor as a direct SSRI target in eliciting cardioprotection in both pressure overload (PO)induced and transverse aortic constriction (TAC)-induced myocardial hypertrophy models in rodents. "
01/15/2011 - "Interestingly, sigma-1 receptor expression in the thoracic aorta decreased significantly 4 weeks after pressure overload-induced hypertrophy in vehicle treated ovariectomized rats. "
01/15/2011 - "Thus, we demonstrate, for the first time, a potential role in the thoracic aorta for sigma-1 receptor expression and signaling via Akt-eNOS in attenuating hypertrophy-induced vascular injury in ovariectomized rats."
01/15/2011 - "Our findings confirm, for the first time, a potential role for sigma-1 receptor expression and signaling in the thoracic aorta in attenuating hypertrophy-induced vascular injury in ovariectomized rats. "

07/26/2022 - "Ayahuasca and its interaction with the sigma-1 receptor: a potential treatment for COVID-19."
01/01/2021 - "Inhibition of SARS-CoV-2 infection in human iPSC-derived cardiomyocytes by targeting the Sigma-1 receptor disrupts cytoarchitecture and beating."
01/01/2021 - " covered: This review examines the role of the sigma-1 receptor and autophagy in SARS-CoV-2 infections and how they may be linked. "
01/01/2021 - "Drugs that offer the potential to reduce hospitalization and mortality from SARS-CoV-2 infection: The possible role of the sigma-1 receptor and autophagy."
03/01/2021 - "Repurposing of CNS drugs to treat COVID-19 infection: targeting the sigma-1 receptor."

09/01/2012 - "Sigma-1 receptor agonist fluvoxamine for delirium in older adults."
04/24/2010 - "Sigma-1 receptor agonist fluvoxamine for delirium in intensive care units: report of five cases."
01/20/2010 - "Sigma-1 receptor agonist fluvoxamine for delirium in patients with Alzheimer's disease."
01/20/2010 - "We report on two cases in which monotherapy of the selective serotonin reuptake inhibitor and sigma-1 receptor agonist fluvoxamine was effective in ameliorating the delirium of patients with Alzheimer's disease. "
01/01/2015 - "Moreover, case reports suggest that sigma-1 receptor agonists, including fluvoxamine, and ifenprodil, may be effective in the treatment of cognitive impairment in schizophrenia, delirium in elderly people, and flashbacks in post-traumatic stress disorder. "