Sterol O-Acyltransferase 2

A sterol O-acyltransferase that catalyzes reaction of Acyl-CoA and cholesterol into CoA and cholesterol ester. It is a distinct enzyme from Acetyl-CoA C-Acetyltransferase 2, which is also referred to as ACAT2.

Also Known As:

Networked: 12 relevant articles (1 outcomes, 2 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Rudel, Lawrence L: 3 articles (11/2015 - 08/2006)
2.	Davis, Matthew A: 2 articles (11/2015 - 10/2014)
3.	He, Xuelian: 2 articles (07/2015 - 12/2005)
4.	Heng, Chew-Kiat: 2 articles (07/2015 - 12/2005)
5.	Yang, Hongyuan: 2 articles (07/2015 - 12/2005)
6.	Brown, J Mark: 2 articles (10/2014 - 08/2006)
7.	Calabresi, Laura: 1 article (01/2022)
8.	Lhomme, Marie: 1 article (01/2022)
9.	Ossoli, Alice: 1 article (01/2022)
10.	Parini, Paolo: 1 article (01/2022)

Related Diseases

1.	Hepatomegaly 10/01/2018 - "When sterol O-acyltransferase 2, a cholesterol esterifying enzyme present in enterocytes and hepatocytes, is eliminated in NPC1-deficient mice, there is a reduction in their hepatomegaly, hepatic UC content, and cellular injury."
2.	Atherosclerosis 08/01/2006 - "The purpose of this study was to determine the effects of liver-specific inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) on the development of hypercholesterolemia and atherosclerosis in mice. " 11/01/2015 - "Sterol O-acyltransferase 2 (SOAT2; also known as ACAT2) is considered as a new therapeutic target for the treatment or prevention of hypercholesterolemia and atherosclerosis. " 10/24/2014 - "Cholesterol esters (CE) derived from hepatic sterol O-acyltransferase 2 (SOAT2) are associated with more atherosclerosis than CE from intestinal SOAT2." 11/01/2003 - "To test the possibility that acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) may be expressed in human macrophages under pathologic conditions, we employed specific anti-ACAT2 antibodies and found clear ACAT2 signals in lipid-laden as well as lipid-free macrophages under various disease conditions, including atherosclerosis. " 01/01/2019 - "Depletion of the cholesterol esterifying enzyme acyl-Coenzyme A: cholesterol acyltransferase 2 (ACAT2, encoded by Soat2) protects mice from atherosclerosis, diet-induced hypercholesterolemia, and hepatic steatosis when fed high-cholesterol diet. "
3.	Hypercholesterolemia 08/01/2006 - "The purpose of this study was to determine the effects of liver-specific inhibition of acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) on the development of hypercholesterolemia and atherosclerosis in mice. " 11/01/2015 - "Sterol O-acyltransferase 2 (SOAT2; also known as ACAT2) is considered as a new therapeutic target for the treatment or prevention of hypercholesterolemia and atherosclerosis. " 01/01/2019 - "Depletion of the cholesterol esterifying enzyme acyl-Coenzyme A: cholesterol acyltransferase 2 (ACAT2, encoded by Soat2) protects mice from atherosclerosis, diet-induced hypercholesterolemia, and hepatic steatosis when fed high-cholesterol diet. " 12/01/2005 - "Acyl-CoA: cholesterol acyltransferase-2 (ACAT2), an intracellular cholesterol esterification enzyme found only in the intestine and liver, has been demonstrated to be associated with hypercholesterolemia and atherosclerosis in mice. " 07/25/2015 - "Acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) plays a critical role in the formation of cholesteryl esters from cholesterol and fatty acids, and is a potential target for treating hypercholesterolemia. "
4.	Lecithin Cholesterol Acyltransferase Deficiency (Lecithin:Cholesterol Acyltransferase Deficiency) 01/01/2022 - "This study of CEFA composition in a large cohort of carriers of LCAT deficiency shows that in the absence of LCAT-derived CEs, CEs present in apoB-containing lipoproteins are derived from hepatic and intestinal sterol O-acyltransferase 2."
5.	Renal Insufficiency (Renal Failure) 01/01/2019 - "CKD resulted in metabolic dyslipidaemia, renal insufficiency, hepatic lipid accumulation, upregulation of 3-hydroxy-3-methyl-glutaryl-coenzyme A (HMG-CoA) reductase, acyl-CoA cholesterol acyltransferase-2 (ACAT2) and the downregulation of LDL receptor protein, VLDL receptor, hepatic lipase, lipoprotein lipase (LPL), lecithin-cholesterol acyltransferase (LCAT) and scavenger receptor class B type 1 (SR-B1). "

Related Drugs and Biologics

1.	Sterol O-Acyltransferase
2.	Lipoproteins (Lipoprotein)
3.	Apolipoproteins B (ApoB)
4.	Lipids
5.	Cholesterol
6.	Cholesterol Esters (Cholesteryl Esters)
7.	Scavenger Receptors (Scavenger Receptor)
8.	LDL Receptors (LDL Receptor)
9.	Proteins (Proteins, Gene)
10.	Lipoprotein Lipase (Diacylglycerol Lipase)