Interleukin-22 (IL-22)

An interleukin that plays a critical role in modulating tissue responses during inflammation, and in WOUND HEALING.

Also Known As:

IL-22; Factor, IL-10-Related T-Cell-Derived-Inducible; IL 10 Related T Cell Derived Inducible Factor; Interleukin 22; T-Cell-Derived-Inducible Factor, IL-10-Related; Zcyto18, Cytokine; Cytokine Zcyto18; IL-10-Related T-Cell-Derived-Inducible Factor; ILTIF

Networked: 1978 relevant articles (123 outcomes, 288 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Gao, Bin: 26 articles (01/2021 - 02/2004)
2.	Ouyang, Wenjun: 25 articles (12/2018 - 02/2007)
3.	Renauld, Jean-Christophe: 24 articles (01/2019 - 08/2002)
4.	Kolls, Jay K: 21 articles (01/2021 - 03/2008)
5.	Dumoutier, Laure: 20 articles (11/2021 - 08/2002)
6.	Sabat, Robert: 20 articles (01/2021 - 08/2004)
7.	Wolk, Kerstin: 18 articles (01/2021 - 08/2004)
8.	Mühl, Heiko: 16 articles (09/2021 - 06/2007)
9.	Zenewicz, Lauren A: 15 articles (01/2022 - 10/2007)
10.	Bachmann, Malte: 15 articles (09/2021 - 06/2007)

Related Diseases

1.	Infections 07/21/2011 - "Blocking of LTβR signaling dramatically reduced intestinal IL-22 production after C. rodentium infection. " 06/01/2022 - "IL-22 plays an important role in wound healing and in the protection against skin infections. " 03/16/2012 - "Interleukin-22 is produced by invariant natural killer T lymphocytes during influenza A virus infection: potential role in protection against lung epithelial damages." 01/01/2021 - "The elevated production of IL-22 in Cxcr5-deficient mice improved gut barrier integrity and protected mice during infection with the opportunistic pathogen Clostridium difficile Interestingly, Cxcr5-/- mice developed LTi-like cell aggregates that were displaced from their typical niche at the intestinal crypt, and LTi-like cell hyperresponsiveness was associated with the local formation of this unconventional SILT. " 11/01/2016 - "IL-22 is produced in the CF lung and in response to PA infection yet is dispensable in protection against chronic pulmonary P. "
2.	Inflammation (Inflammations) 11/01/2022 - "Furthermore, IL-22 treatment activated autophagy and inhibited TLR4/NF-κB signaling pathway in vitro, suggesting that IL-22-activated autophagy and -inhibited inflammation also participated in the protective effects of MgIG. " 11/01/2023 - "In conclusion, the results of this study suggested that COS had a good inhibitory effect on IDO1 under inflammation and the changes of AHR and IL-22 levels at different stages of disease development. " 03/01/2016 - "The present study suggests that IL-22 might be involved in regulating inflammation and controlling the cell proliferation in SjS. " 11/01/2015 - "This study will help identify new therapeutic strategies for OA, especially the targeting of IL-22 to decrease inflammation." 07/01/2013 - "In this study, we show that IL-22 deficiency in donor T cells can decrease the severity of aGVHD, while limiting systemic and local inflammation in aGVHD target organs. "
3.	Psoriasis (Pustulosis Palmaris et Plantaris) 04/01/2019 - "Targeting IL-22 may be promising as a potential therapeutic for plaque psoriasis." 06/01/2023 - "The purpose of this study was to analyze the involvement of circ_0082476 in Interleukin-22 (IL-22)-induced psoriasis. " 10/01/2022 - "The aim of this study was to correlate serum levels of IL-22 and Staphylococcus aureus toxins with disease activity in plaque psoriasis. " 04/01/2019 - "The aim of this study was the assessment of IL-22 levels and its correlation with disease activity in plaque psoriasis. " 09/01/2018 - "The aim of our study was to explore the possible functional role of miR-20a-3p in psoriasis and in IL-22 induced keratinocyte proliferation. "
4.	Colitis 04/01/2016 - "IL-22 Restrains Tapeworm-Mediated Protection against Experimental Colitis via Regulation of IL-25 Expression." 07/01/2017 - "Recent study showed that CARD9 mice are more susceptible to colitis as a result of impaired interleukin 22 signaling pathway. " 01/01/2023 - "fragilis may indirectly motivate ILC3 to secrete IL-22, followed by IL-22-induced STAT3 phosphorylation, hence promoting colonic mucosa regeneration in colitis. " 01/01/2023 - "fragilis promoted IL-22 production, and increased the percentage of IL-22-secreting type 3 innate lymphocytes (ILC3) in colitis. " 01/01/2023 - "Bacteroides fragilis strain ZY-312 facilitates colonic mucosa regeneration in colitis via motivating STAT3 signaling pathway induced by IL-22 from ILC3 secretion."
5.	Ulcerative Colitis 01/01/2022 - "We encapsulated IL-22-mRNA within the nLNPs, as enhanced IL-22 expression in the colon is known to have potent anti-inflammatory efficacy against ulcerative colitis (UC). " 08/01/2017 - "The Th17/IL-23 pathway and IL-22 serve important roles in the pathogenesis of ulcerative colitis, and will be further examined by study." 07/13/2023 - "These protective properties of IL-22 may offer a potential treatment for ulcerative colitis (UC). " 04/05/2023 - "Interleukin-22 (IL-22) has been demonstrated as a critical regulator of epithelial homeostasis and repair; it showed an anti-inflammatory effect against ulcerative colitis. " 03/01/2023 - "Role of Interleukin-22 in ulcerative colitis."

Related Drugs and Biologics

1.	Interleukin-17 (Interleukin 17)
2.	Cytokines
3.	Proteins (Proteins, Gene)
4.	Interleukin-23 (Interleukin 23)
5.	Messenger RNA (mRNA)
6.	Interleukin-10 (Interleukin 10)
7.	STAT3 Transcription Factor (Signal Transducer and Activator of Transcription 3)
8.	Glucose (Dextrose)
9.	Interleukin-6 (Interleukin 6)
10.	Interleukin-22 (IL-22)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Oral Administration
4.	Glycemic Control
5.	Transplantation