Acylphosphatase

An enzyme that catalyzes the conversion of an acylphosphate and water to a carboxylate and phosphate.

Also Known As:

Phosphatase, Acetic; Phosphatase, CAP; Phosphatase, Carbamyl Phosphate; Phosphate Phosphatase, Carbamyl; Phosphohydrolase, Acylphosphate; Acetic Phosphatase; Acylphosphate Phosphohydrolase; CAP Phosphatase; Carbamyl Phosphate Phosphatase

Networked: 22 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Enzymes and Coenzymes: 1
- Enzymes: 152586
  - Hydrolases: 2166
    - Acid Anhydride Hydrolases
      - Acylphosphatase: 22
        Drosophila Acyp2 protein
        human ACYP1 protein
        human ACYP2 protein

Experts

1.	Akita, Hirofumi: 1 article (01/2022)
2.	Asaoka, Tadafumi: 1 article (01/2022)
3.	Chang, Xueliang: 1 article (01/2022)
4.	Doki, Yuichiro: 1 article (01/2022)
5.	Eguchi, Hidetoshi: 1 article (01/2022)
6.	Gotoh, Kunihito: 1 article (01/2022)
7.	Han, Zhenwei: 1 article (01/2022)
8.	Iwagami, Yoshifumi: 1 article (01/2022)
9.	Kitagawa, Akihiro: 1 article (01/2022)
10.	Kobayashi, Shogo: 1 article (01/2022)

Related Diseases

1.	Breast Neoplasms (Breast Cancer) 01/01/2018 - "The purpose of this study was to investigate the impact of single nucleotide polymorphisms (SNPs) in the acylphosphatase 2 gene and the SNP-SNP interactions on breast cancer (BC) risk in Chinese Han women. " 01/01/2018 - "Single Nucleotide Polymorphisms in the Acylphosphatase 2 Gene and The SNP-SNP Interactions on the Risk of Breast Cancer in Chinese Han Women." 12/27/2016 - "We performed a case-control study to investigate the associations between seven single nucleotide polymorphisms (SNPs) in the acylphosphatase 2 (ACYP2) gene and breast cancer (BC) risk in a Han Chinese population. " 12/27/2016 - "Genetic variants in the acylphosphatase 2 gene and the risk of breast cancer in a Han Chinese population." 10/05/2004 - "An N-terminal catalytic domain of CPL1, which suffices for CTD Ser-5 phosphatase activity in vitro, includes a signature DXDXT acylphosphatase motif, but lacks a breast cancer 1 CTD, which is an essential component of the fungal and metazoan Fcp1 CTD phosphatase enzymes. "
2.	Neuroblastoma 07/01/2004 - "An acylphosphatase (AcPase) overexpression study was carried out on SH-SY5Y neuroblastoma cells, using a green fluorescent fusion protein (AcP-GFP), with GFP acting as a reporter protein. " 10/01/1997 - "Alteration of intracellular free calcium and acylphosphatase levels in differentiating SH-SY5Y neuroblastoma cells." 10/01/1997 - "Levels of acylphosphatase isoenzymes and free intracellular calcium have been investigated in cultured SH-SY5Y human neuroblastoma cells under stimulation with all-trans retinoic acid and phorbol-12-myristate-13-acetate. "
3.	Neoplasms (Cancer) 07/01/2023 - "Acylphosphatase 1 (ACYP1), a protein located in the mammalian cell cytoplasm, has been shown to be associated with tumor initiation and progression by functioning as a metabolism-related gene. " 12/01/1997 - "Changes in the activity of the Na+/K(+)-ATPase pump, regulated by acylphosphatase, have been previously reported in chemically-induced colonic tumors. " 01/01/2022 - "The following combinations of main keywords were used: (ACYP2 OR acylphosphatase 2) AND (polymorphism OR mutation OR variation OR SNP OR genotype) AND (cancer OR tumor OR neoplasm OR malignancy OR carcinoma OR adenocarcinoma). " 01/01/2022 - "Acylphosphatase 1 is a cytosolic enzyme that produces acetic acid from acetyl phosphate and plays an important role in cancer progression. "
4.	Carcinoma (Carcinomatosis) 10/01/1984 - "This CAP phosphatase activity was studied from tissue preparations of Ehrlich ascites carcinoma cells, SV-40-transformed Syrian hamster cells, and normal tissues of the rat. " 01/01/2022 - "The following combinations of main keywords were used: (ACYP2 OR acylphosphatase 2) AND (polymorphism OR mutation OR variation OR SNP OR genotype) AND (cancer OR tumor OR neoplasm OR malignancy OR carcinoma OR adenocarcinoma). "
5.	Alzheimer Disease (Alzheimer's Disease) 06/07/1996 - "Alteration of acylphosphatase levels in familial Alzheimer's disease fibroblasts with presenilin gene mutations." 06/07/1996 - "Acylphosphatase (AcPase), an enzyme that modulates the activity of Ca(2+)-ATPase by hydrolysing its phosphorylated moiety, has been found to be significantly higher in cultured skin fibroblasts from donors affected by early onset familial Alzheimer's disease (EOFAD) with PS-1 and PS-2 gene mutations. " 05/04/1990 - "Hexokinase, lactate dehydrogenase, acylphosphatase, (Na+,K+)-ATPase and Ca2(+)-ATPase of selected areas from postmortem Alzheimer's disease brains were studied. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Enzymes
3.	Adenosine Triphosphatases (ATPase)
4.	L-Lactate Dehydrogenase (Lactate Dehydrogenase)
5.	Hexokinase
6.	Presenilins
7.	Cytochromes c (Cytochrome c)
8.	Integrin alpha1
9.	Protein Isoforms (Isoforms)
10.	Acetic Acid (Vinegar)