Calponins

A family of actin binding proteins mostly in smooth muscle. Calponins include most abundant alpha-calponin (h1 or basic); beta-calponin; neutral calponin (h2 calponin); acidic calponin, SM22, and transgelin. Calponin family members have N-terminal single Calponin Homology (CH) domain and multiple C-terminus 23-amino acids long calponin-like repeats called CLICK-23. Calponins participate in modulation of smooth muscle contraction by binding to ACTINS (F- and G-Actins), CALMODULIN and TROPOMYSIN.

Also Known As:

Networked: 416 relevant articles (7 outcomes, 44 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Jin, J-P: 7 articles (01/2021 - 01/2008)
2.	Takahashi, Katsuhito: 7 articles (01/2019 - 02/2002)
3.	Jin, Jian-Ping: 6 articles (03/2022 - 03/2006)
4.	Yamamura, Hisako: 6 articles (01/2013 - 02/2002)
5.	Nagao, Toshitaka: 5 articles (12/2021 - 06/2008)
6.	Kreipke, Christian W: 5 articles (01/2017 - 05/2006)
7.	Reymundo, C: 5 articles (07/2011 - 03/2002)
8.	Ehara, Takashi: 5 articles (04/2010 - 08/2002)
9.	Taniguchi, Shun'ichiro: 5 articles (04/2010 - 08/2002)
10.	Weinreb, Ilan: 4 articles (12/2021 - 09/2010)

Related Diseases

1.	Neoplasms (Cancer) 08/22/2017 - "Our study suggests that the upregulation of calponin 2 in PDAC correlates to lower malignancy and presents a novel target for the development of new treatment." 11/01/2015 - "Although several studies have demonstrated the tumor suppressive function of CNN1 (calponin 1), no studies have performed a site-specific analysis of CNN1 on tumor cell activities. " 12/01/2005 - "In addition, with immunohistochemical studies, the tumor cells were stained for calponin but not for cluster differentiation (CD)-31, CD-34, alpha-smooth muscle actin or S-100." 05/15/2001 - "In this study, we show that expression of the calponin gene in human soft tissue and bone tumor cells is regulated at the transcriptional level by the sequence between positions -260 and -219 upstream of the translation initiation site. " 01/01/2023 - "Background: Emerging evidence has suggested a pro-oncogenic role of calponin 1 (CNN1) in the initiation of a variety of cancers. "
2.	Inflammation (Inflammations) 04/30/2020 - "The expression of TS in the MECs of all the salivary adenoid specimens was highly consistent with those of P63, Calponin, CK5/6 and S-100 (P>0.05) Except for CK5/6 expression in Salivary inflammation and Salivary gland specimens. " 05/01/2011 - "low inflammation based on IL-10 values) and VSMCs (expressing calponin, a marker of contractility). " 10/01/2016 - "The increased phagocytotic activity of calponin 2-null macrophages may facilitate the clearance of autoimmune complexes and the resolution of inflammation, whereas the decreased substrate adhesion may reduce osteoclastogenesis and bone resorption. " 04/01/1999 - "Two cases of DCIS with prominent periductal fibrosis or inflammation were positive for calponin, but the periductal stromal cells were calponin- and SMMHC-negative. " 11/01/2017 - "Cholesterol loading downregulates the expression of Acta2 and calponin (SMC markers), and increases the expression of Mac-2, CD11b and MHCII (inflammation-related genes and surface antigens) and Abca1, Abcg1. "
3.	Leiomyosarcoma 05/05/1999 - "In this study, we sought to assess the effects (in vitro and in vivo) of increasing calponin h1 expression in leiomyosarcoma cells. " 06/21/2012 - "Potential role of LMP2 as an anti-oncogenic factor in human uterine leiomyosarcoma: morphological significance of calponin h1." 09/01/2002 - "D12CALP also revealed the cell-specific replication to leiomyosarcoma in which calponin expression was augmented. " 05/05/1999 - "In assays of anchorage-independent growth and in vivo tumorigenicity, both growth and tumorigenicity were statistically significantly reduced in calponin h1-transfected leiomyosarcoma cells. " 07/01/1998 - "Reduced expression of calponin h1 in leiomyosarcoma of the uterus."
4.	Noninfiltrating Intraductal Carcinoma (DCIS) 11/08/2011 - "Our results demonstrated that using FAP-α and Calponin adjunctively improved the sensitivity of pathological diagnosis of DCIS-MI by 11.29%, whereas the adjunctive use of FAP-α and Calponin improved the sensitivity of pathological diagnosis of DCIS by 13.6%. " 11/08/2011 - "This study provides the first evidence that immunostaining with FAP-α and Calponin can serve as a novel marker for pathologically diagnosing whether DCIS has microinvasion." 04/01/2018 - "A METHOD FOR QUANTIFICATION OF CALPONIN EXPRESSION IN MYOEPITHELIAL CELLS IN IMMUNOHISTOCHEMICAL IMAGES OF DUCTAL CARCINOMA IN SITU." 11/01/2015 - "These results suggest that further research is warranted into the role of myoepithelial cell p63 and calponin expression on DCIS progression to invasive disease. " 11/01/2015 - "Progressive loss of the myoepithelial cell differentiation markers p63, calponin, and α-smooth muscle actin was observed in the mouse myoepithelium surrounding DCIS-involved ducts. "
5.	Neointima 10/01/2013 - "We confirmed the sirolimus-mediated increase of migration from the adventitial into the intima side using an ex vivo decellularized vessel scaffold, where they form neointima-like lesions that expressed high levels of smooth muscle cell (SMC) markers (SM-22α and calponin). " 07/01/2004 - "(3) In actively growing V (AV), alpha-SM actin, calponin and vinculin were 3-, 3.3- and 2.9-fold lower, respectively, in the neointima as compared to the media. " 11/01/1998 - "The most obvious difference with normal vessels is the reiteration of an embryonal expression pattern in smooth muscle cells of the neointima which includes a significant reduction of desmin and alpha-smooth muscle actin, calponin and vinculin. " 07/01/2004 - "Our findings indicate that induction of Cx37 and reduction of desmin precede the phenotypic changes of SMCs, which are characterized by down-regulation of alpha-SM actin, calponin and vinculin, and the formation of a neointima. " 12/01/2022 - "The immunohistochemistry study showed that as compared with the vehicle, clopidogrel significantly decreased the rate of proliferating cell nuclear antigen-positive cells in the wall of vein grafts and significantly increased the expression of vascular smooth muscle cell (VSMC) contractile protein markers (α-smooth muscle actin, calponin, and SM22) within the neointima area of vein grafts. "

Related Drugs and Biologics

1.	Desmin
2.	Tropomyosin
3.	Vinculin
4.	Peptides (Polypeptides)
5.	Vimentin
6.	Proteins (Proteins, Gene)
7.	Catenins
8.	Calmodulin-Binding Proteins (Caldesmon)
9.	Myosin Heavy Chains (Myosin Heavy Chain)
10.	Contractile Proteins

Related Therapies and Procedures

1.	Therapeutics
2.	Stents
3.	Ligation
4.	Aftercare (After-Treatment)
5.	Transjugular Intrahepatic Portasystemic Shunt