Urea Transporters

Transmembrane carrier proteins responsible for urea movement across the cell membrane. Urea transporters are divided into renal tubular/testicular type (urea transporter 2 consisting of (UT) A1 to A5, encoded by SLC14A2 gene) and erythrocyte type (urea transporter 2 or UT-B1 encoded by the SLC14A1 gene). In humans mutations on the SLC14A1 gene determines KIDD BLOOD-GROUP SYSTEM.

Also Known As:

Networked: 28 relevant articles (0 outcomes, 4 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Sands, Jeff M: 8 articles (06/2016 - 11/2002)
2.	Klein, Janet D: 6 articles (06/2016 - 06/2004)
3.	Meng, Yan: 3 articles (01/2022 - 09/2014)
4.	Sands, J M: 3 articles (02/2003 - 03/2000)
5.	Sun, Yuxin: 2 articles (01/2022 - 12/2018)
6.	Zhang, Ling: 2 articles (12/2018 - 09/2014)
7.	Bailey, James L: 2 articles (06/2016 - 08/2005)
8.	Yang, Baoxue: 2 articles (02/2016 - 09/2014)
9.	Blount, Mitsi A: 2 articles (12/2012 - 04/2011)
10.	Li, Jiajing: 1 article (01/2022)

Related Diseases

1.	Uremia 06/01/2016 - "Urea transporters and sweat response to uremia." 07/01/2013 - "To explore the expression of urea transporters (UTs) in the skin and sweat glands of normal subjects and patients with uremia. " 01/01/2003 - "For example, (a) vasopressin increases the phosphorylation of UT-A1 in rat inner medullary collecting duct; (b) UT-A1 protein abundance is increased in the rat inner medulla during conditions in which urine-concentrating ability is reduced; and (c) urea transporters are expressed in non-renal tissues, and UT-A protein abundance is up-regulated in uremia in both liver and heart. " 11/01/2002 - "Polyclonal antibodies have been generated to the cloned urea transporter proteins, and the use of these antibodies in integrative animal studies has resulted in several novel findings, including: (1) the surprising finding that UT-A1 protein abundance and urea transport are increased in the inner medulla during conditions in which urine concentrating ability is reduced; (2) vasopressin increases UT-A1 phosphorylation in rat inner medullary collecting duct; (3) UT-A protein abundance is upregulated in uremia in both liver and heart; and (4) UT-B is expressed in many nonrenal tissues and endothelial cells. " 02/01/2003 - "Polyclonal antibodies were generated to the cloned urea transporter proteins, and their use in integrative animal studies resulted in several novel findings, including: (1) UT-B is the Kidd blood group antigen; (2) UT-B is also expressed in many non-renal tissues and endothelial cells; (3) vasopressin increases UT-A1 phosphorylation in rat inner medullary collecting duct; (4) the surprising finding that UT-A1 protein abundance and urea transport are increased in the inner medulla during conditions in which urine concentrating ability is reduced; and (5) UT-A protein abundance is increased in uremia in both liver and heart. "
2.	Inflammation (Inflammations) 05/01/2007 - "The present study attempts to assess the regulation of renal urea transporters during severe inflammation in vivo. " 05/01/2007 - "Our data demonstrate that renal urea transporters are downregulated by severe inflammation, which likely accounts for tubular dysfunction. "
3.	Decompression Sickness (Bends) 11/01/2008 - "These studies have shown that 1) IM descending thin limbs (DTLs) have at least two or three functionally distinct subsegments; 2) most ascending thin limbs (ATLs) and about half the ascending vasa recta (AVR) are arranged among clusters of collecting ducts (CDs), which form the organizing motif through the first 3-3.5 mm of the IM, whereas other ATLs and AVR, along with aquaporin-1-positive DTLs and urea transporter B-positive descending vasa recta (DVR), are external to the CD clusters; 3) ATLs, AVR, CDs, and interstitial cells delimit interstitial microdomains within the CD clusters; and 4) many of the longest loops of Henle form bends that include subsegments that run transversely along CDs that lie in the terminal 500 microm of the papilla tip. "
4.	Polyuria 01/01/2020 - "Mice with induced deletions of both Pax2 and Pax8 exhibit severe polyuria that can be attributed to significant changes in the expression of solute carriers, such as the urea transporters encoded by Slc14a2, as well as aquaporins within the inner and outer medulla. " 01/01/2003 - "Correction of age-related polyuria by dDAVP: molecular analysis of aquaporins and urea transporters." 12/01/2001 - "Cisplatin (CP) induced polyuria in rats is associated with a reduction in medullary hypertonicity, normally generated by the thick ascending limb (TAL) salt transporters, and the collecting duct urea transporters (UT). " 12/01/2001 - "Expression of salt and urea transporters in rat kidney during cisplatin-induced polyuria."
5.	Urinary Bladder Neoplasms (Bladder Cancer) 12/15/2013 - "Genome-wide association studies (GWAS) identified associations between markers within the solute carrier family 14 (urea transporter), member 1 (SLC14A1) gene and risk of bladder cancer. " 12/01/2017 - "Solute carrier family 14 member 1 (SLC14A1) gene encodes the type-B urea transporter (UT-B) which facilitates the passive movement of urea across cell membrane, and has recently been related with human malignancies, especially for bladder cancer. " 01/01/2023 - "A biomimetic fusogenic liposomalized nanoporter (FLNP) that is decorated with urea transporter-B (UT-B) is first synthesized with protonated chitosan oligosaccharide for bladder tumor-targeted co-delivery of urease and small interfering RNA targeting CPS1 (siCPS1). "

Related Drugs and Biologics

1.	Urea (Carbamide)
2.	Proteins (Proteins, Gene)
3.	Vasopressins (Vasopressin)
4.	Antibodies
5.	Aquaporin 1
6.	Blood Group Antigens (Blood Groups)
7.	Aquaporins (Water Channels)
8.	Cytokines
9.	Lithium
10.	Chitosan

Related Therapies and Procedures

1.	Protein-Restricted Diet (Diet, Protein Restricted)
2.	Controlled Hypotension