ProTides

A class of prodrugs consisting of a 5'-nucleoside monophosphate in which the two hydroxyl groups are masked with an amino acid ester and an aryloxy component which once in the cell is enzymatically metabolized to deliver free 5'-monophosphate, and further transformed to the active 5'-triphosphate form of the nucleoside analogue.

Also Known As:

Networked: 52 relevant articles (3 outcomes, 3 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	McGuigan, Christopher: 9 articles (02/2020 - 05/2005)
2.	Serpi, Michaela: 4 articles (12/2021 - 09/2008)
3.	Balzarini, Jan: 4 articles (02/2015 - 05/2005)
4.	Blagden, Sarah P: 2 articles (12/2021 - 10/2018)
5.	Harrison, David J: 2 articles (12/2021 - 01/2019)
6.	Um, In Hwa: 2 articles (12/2021 - 01/2019)
7.	Jordan, Robert: 2 articles (10/2020 - 01/2017)
8.	Babusis, Darius: 2 articles (06/2020 - 01/2017)
9.	Niu, Congrong: 2 articles (06/2020 - 02/2011)
10.	Park, Yeojin: 2 articles (06/2020 - 01/2017)

Related Diseases

1.	Neoplasms (Cancer) 01/01/1988 - "Protides Biol Fluids 1983; 30:337-352) and independently confirmed by others on 354 (Bogoch et al. Protides Biol Fluids 1984; 31: 739-747) cancer patients and controls. " 01/15/1980 - "This protide is believed to regulate the rate of extravasation of tumor cells. " 01/01/1959 - "[Behavior of some hematic values of glucide and protide exchange in the radiotherapy of tumors]." 05/01/2016 - "Depending on the cancer cell line studied and on the nature of the parent nucleoside compound (gemcitabine, 5-iodo-2'-deoxy-uridine, floxuridine or brivudin), the corresponding ProTides are endowed with an improved or decreased cytotoxic activity." 12/01/2021 - "Our study provides proof that NUC-7738 overcomes cellular resistance mechanisms and supports its further clinical evaluation as a novel cancer treatment within the growing pantheon of anticancer ProTides."
2.	Henipavirus Infections 01/01/2023 - "Remdesivir is a nucleotide prodrug with preclinical efficacy against lethal Nipah virus infection in African green monkeys when administered 1 day post inoculation (dpi) (Lo et al., 2019). "
3.	Insulin Resistance 01/01/2020 - "Here, we showed that remdesivir (RDV, GS-5734), as a broad-spectrum antiviral nucleotide prodrug with anti-inflammatory effects, was effective for attenuating HFD-induced metabolic disorder and insulin resistance. "
4.	COVID-19 05/17/2020 - "Remdesivir is a nucleotide prodrug that is currently undergoing extensive clinical trials for the treatment of COVID-19. " 01/05/2022 - "Remdesivir, an intravenous nucleotide prodrug, has been approved for treating COVID-19 in hospitalized adults and pediatric patients. " 10/27/2020 - "Remdesivir is a broad-spectrum antiviral nucleotide prodrug that has been clinically evaluated in Ebola virus patients and recently received emergency use authorization (EUA) for treatment of COVID-19. " 01/07/2021 - "Self-immolation (SI) is the key principle of ProTide nucleotide prodrugs such as remdesivir, which is currently used to treat COVID-19 patients. " 01/01/2023 - "Aviptadil, a lung-protective neuropeptide, and remdesivir, a nucleotide prodrug of an adenosine analog, were compared with placebo among patients with COVID-19 acute hypoxaemic respiratory failure. "
5.	Hepatitis C 01/01/2015 - "The assay was successfully applied to pharmacokinetic studies of 2'-MeGTP in liver tissue samples after single oral doses of IDX184, a nucleotide prodrug inhibitor of the viral polymerase for the treatment of hepatitis C, to mice. " 06/01/2020 - "Sofosbuvir (SOF) is a nucleotide prodrug which has been used as a backbone for the clinical treatment of hepatitis C viral infection. " 05/01/2016 - "Single- and repeat-dose toxicity of IDX14184, a nucleotide prodrug with antiviral activity for hepatitis C viral infection, in mice, rats, and monkeys." 01/01/2017 - "Human Hint1 has been shown to be essential for the metabolic activation of nucleotide antiviral pronucleotides (i.e., proTides), such as the FDA approved hepatitis C drug, sofosbuvir. " 05/01/2016 - "The single- and repeat-dose toxicity profile of IDX14184, a novel guanosine nucleotide prodrug with antiviral activity against hepatitis C viral infection, was characterized following once daily oral administration for durations up to 13, 26, and 32 weeks in mouse, rat, and cynomolgus monkey, respectively. "

Related Drugs and Biologics

1.	remdesivir
2.	Antiviral Agents (Antivirals)
3.	Nucleosides
4.	IDX184
5.	NUC-7738
6.	phosphoramidic acid
7.	Prodrugs
8.	Nucleotides
9.	Gemcitabine
10.	Sofosbuvir

Related Therapies and Procedures

1.	Therapeutics
2.	Liver Transplantation
3.	Radiotherapy
4.	Hemodilution
5.	Oral Administration