On the prevention of haematogenous tumour metastasis to liver and lung.

Abstract

Vascular endothelium is lined by a layer of alpha, 2, macroglobulin (AMG). This protide is believed to regulate the rate of extravasation of tumor cells. Experiments are described which show that increasing the deposition of AMG (enhancing its production and blocking its lysis) reduces the incidence of tumour metastases to liver and lung.

• Authors: R Stein-Werblowsky
• Journal: Experientia (Experientia) Vol. 36 Issue 1 Pg. 108-9 (Jan 15 1980) ISSN: 0014-4754 [Print] Switzerland
• PMID: 6153619 (Publication Type: Journal Article)

Chemical References

• alpha-Macroglobulins
• Aprotinin

Topics

• Animals
• Aprotinin (pharmacology)
• Female
• Liver Neoplasms (prevention & control, secondary)
• Lung Neoplasms (prevention & control, secondary)
• Male
• Neoplasms, Experimental (pathology)
• Neoplastic Cells, Circulating
• Rats
• alpha-Macroglobulins (metabolism)