Ascending Aorta Aneurysm

An abnormal balloon- or sac-like dilatation in the wall of the ASCENDING AORTA.

Also Known As:

Aneurysm, Ascending Aorta; Aneurysm, Ascending Aortic; Aorta Aneurysm, Ascending; Aortic Aneurysm, Ascending; Ascending Aorta Aneurysms; Ascending Aortic Aneurysms; AAA Ascending Aorta Aneurysm; Ascending Aortic Aneurysm

Networked: 288 relevant articles (3 outcomes, 16 trials/studies)

Relationship Network

Disease Context: Research Results

Cardiovascular Diseases: 91362
- Vascular Diseases: 15138
  - Aneurysm: 24506
    - Aortic Aneurysm: 3427
      - Thoracic Aortic Aneurysm: 1399
        Ascending Aorta Aneurysm: 288
  - Aortic Diseases: 879
    - Aortic Aneurysm: 3427
      - Thoracic Aortic Aneurysm: 1399
        Ascending Aorta Aneurysm: 288

Related Diseases

1.	Mitral Valve Insufficiency (Mitral Regurgitation)
2.	Bicuspid Aortic Valve Disease
3.	Aortic Dissection
4.	Aortic Valve Insufficiency (Aortic Regurgitation)
5.	Ventricular Remodeling

Experts

1.	Daugherty, Alan: 9 articles (12/2021 - 04/2008)
2.	Cassis, Lisa A: 7 articles (12/2021 - 04/2008)
3.	Rateri, Debra L: 6 articles (01/2015 - 04/2008)
4.	Elefteriades, John A: 5 articles (02/2022 - 09/2005)
5.	Ruvolo, Giovanni: 5 articles (01/2022 - 03/2016)
6.	Franco-Cereceda, Anders: 4 articles (11/2022 - 08/2012)
7.	Balistreri, Carmela Rita: 4 articles (01/2022 - 01/2019)
8.	Pisano, Calogera: 4 articles (01/2022 - 01/2018)
9.	Discher, Philipp: 4 articles (01/2020 - 01/2016)
10.	Kari, Fabian A: 4 articles (01/2020 - 01/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Ascending Aorta Aneurysm:

1.	Gonadal Steroid Hormones (Sex Hormones)IBA 11/01/2020 - "A validated mouse model capable of recapitulating the protective effects of female sex hormones on ascending aortic aneurysms and dissections (AADs)."
2.	Matrix Metalloproteinases (MMPs)IBA 09/30/2010 - "The aim of the present study was to evaluate the expression changes of adhesion molecules and MMPs in an experimental model of ascending aortic aneurysm induced by ascending aorta banding in Wistar rats. " 01/01/2019 - "A potential key mechanism in ascending aortic aneurysm development: Detection of a linear relationship between MMP-14/TIMP-2 ratio and active MMP-2." 01/01/2012 - "Elevation of matrix metalloproteinases in different areas of ascending aortic aneurysms in patients with bicuspid and tricuspid aortic valves." 11/01/2011 - "However, there are no published reports correlating, Hc and MMP levels in patients with ascending aortic aneurysms (AAAs). " 11/01/2010 - "To test our hypothesis, expression levels of 10 MMPs and 4 TIMPs were assessed by real-time PCR in dilated and normal aortic tissue derived from patients that underwent elective surgical repair of ascending aorta aneurysm (AAA) and coronary artery by-pass grafting, respectively. "
3.	MicroRNAs (MicroRNA)IBA 10/01/2016 - "Several studies appointed microRNAs (miRs) as essential epigenetic factors in various human diseases; however, little is known about their role in ascending aortic aneurysm. " 01/01/2023 - "Expression of Tissue microRNAs in Ascending Aortic Aneurysms and Dissections." 10/01/2016 - "Unbiased Profile of MicroRNA Expression in Ascending Aortic Aneurysm Tissue Appoints Molecular Pathways Contributing to the Pathology." 11/01/2020 - "A total of 76 variables from 125 patients with ascending aortic aneurysms were collected from (1) blood plasma to measure plasma levels of miRNAs and protein activity; (2) computational flow analysis to estimate peak systolic WSS and time-average WSS (TAWSS); and (3) imaging analysis of computed tomography angiography to determine aortic wall strain. " 11/01/2020 - "This study aims to investigate the association of wall shear stress (WSS) and aortic strain with circulating biomarkers including matrix metalloproteinases (MMP), tissue inhibitors of metalloproteinase (TIMP), and exosomal level of microRNA (miRNA) in ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valve. "
4.	Angiotensin IIIBA 03/04/2011 - "The aim of this study was to define the role of angiotensin II type 1a (AT(1a)) receptors and their cellular location in Ang II-induced ascending aortic aneurysms (AAs). " 08/01/2016 - "Insights into ascending aortic aneurysm pathogenesis using in vivo and ex vivo imaging systems in angiotensin II-infused mice." 04/01/2016 - "We visualized and quantified the dissections that lead to ascending aortic aneurysms in angiotensin II-infused mice and provided unique insight into the temporal evolution of these lesions." 04/01/2016 - "Ascending Aortic Aneurysm in Angiotensin II-Infused Mice: Formation, Progression, and the Role of Focal Dissections." 07/01/2015 - "Angiotensin II induces an increase in MMP-2 expression in idiopathic ascending aortic aneurysm via AT1 receptor and JNK pathway."
5.	Biomarkers (Surrogate Marker)IBA 01/18/2022 - "Oxidative Stress in the Pathogenesis of Aorta Diseases as a Source of Potential Biomarkers and Therapeutic Targets, with a Particular Focus on Ascending Aorta Aneurysms." 11/01/2020 - "A combination of shear stress and circulating biomarkers has the potential to improve the decision-making process for ascending aortic aneurysms to a highly individualized level." 11/01/2020 - "Increased flow-based and structural descriptors of ascending aortic aneurysms are associated with high levels of circulating biomarkers, implicating adverse vascular remodeling in the dilated aorta by mechanotransduction. " 06/22/2018 - "Candidate plasma biomarkers for predicting ascending aortic aneurysm in bicuspid aortic valve disease." 01/01/2016 - "The need for biological markers of aortic wall stress and risk of rupture or dissection of ascending aortic aneurysms is obvious. "
6.	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 07/15/2015 - "In this study, statin treatment is associated with reduced growth rate of ascending aorta aneurysms. " 08/01/2021 - " Propensity-matched statin and nonstatin users were aged 64 ± 11 years, 394 (69%) versus 387 (68%) were male, and 437 (77%) versus 442 (78%) had ascending aortic aneurysms, respectively. " 12/01/2018 - "Statins have no apparent clinical impact on perioperative outcomes after ascending aortic aneurysm repair. " 07/15/2015 - "Effects of statin therapy on ascending aorta aneurysms growth: A propensity-matched analysis."
7.	Metalloproteases (Metalloproteinases)IBA 03/01/2009 - "Tissue diffusion and retention of metalloproteinases in ascending aortic aneurysms and dissections." 11/01/2020 - "This study aims to investigate the association of wall shear stress (WSS) and aortic strain with circulating biomarkers including matrix metalloproteinases (MMP), tissue inhibitors of metalloproteinase (TIMP), and exosomal level of microRNA (miRNA) in ascending aortic aneurysms of patients with bicuspid or tricuspid aortic valve. "
8.	Matrix Metalloproteinase 2 (Gelatinase A)IBA 01/01/2017 - "Characterization of serum matrix metalloproteinase 2/9 levels in patients with ascending aortic aneurysms." 01/01/2017 - "The objectives of this study were to identify interrelations between matrix metalloproteinase-2 (MMP2)/MMP9 levels and clinical variables in patients with aortic root/ascending aortic aneurysms and to describe comorbidities as possible biasing factors in the widely discussed correlation of serum MMP levels and aortic diameter. " 01/01/2020 - "Matrix Metalloproteinase-2 Isoforms Differ within the Aortic Wall of Ascending Aortic Aneurysms Associated with Bicuspid Aortic Valve."
9.	Galectin 3 (LGALS3)IBA 01/01/2021 - "The present study aims to observe the changes in galectin-3 (Gal-3) expression levels in patients with an ascending aortic aneurysm and ventricular remodeling and analyze Gal-3's correlation with ventricular remodeling. " 01/01/2021 - "Correlation Study of Galectin-3 in Patients with an Ascending Aortic Aneurysm and Ventricular Remodeling Before and After Surgical Correction."
10.	Small Cytoplasmic RNAIBA 12/30/2021 - "In this study, we examined the changes of aortic cell populations and gene expression in MFS by performing single-cell RNA sequencing (scRNA seq) on ascending aortic aneurysm tissues from patients with MFS (n = 3) and age-matched non-aneurysmal control tissues from cardiac donors and recipients (n = 4). "

Therapies and Procedures

1.	Cardiopulmonary Bypass (Heart-Lung Bypass) 05/01/2011 - "Cardiac surgery with cardiopulmonary bypass is still the gold standard to treat ascending aortic aneurysms. " 10/01/2019 - "Purpose: To describe a hybrid procedure that avoids cardiopulmonary bypass to treat patients with true ascending aortic aneurysms without a suitable proximal landing zone for endovascular repair. " 06/01/2015 - "Ascending aortic aneurysms are usually treated with graft replacement under cardiopulmonary bypass. " 11/01/1969 - "Surgical treatment of ascending aortic aneurysms by means of cardiopulmonary bypass." 09/01/1969 - "Successful resection of an ascending aortic aneurysm under cardiopulmonary bypass associated with carotid and coronary perfusion."
2.	Stents 10/01/2019 - "Endovascular Hybrid Repair of True Ascending Aortic Aneurysms Using Double Graft Wrapping to Prepare a Landing Zone for Ascending Aortic Stent-Graft Placement: A Cohort Study." 08/01/2015 - "To report the use of an investigational stent-graft to treat an ascending aortic aneurysm in a patient with a heart transplant. " 02/01/2013 - "To demonstrate transapical stent-graft implantation for the treatment of an ascending aortic aneurysm simultaneously using the "periscope" technique for all supra-aortic branches. " 09/01/2007 - "[Open stent implantation for ascending aorta aneurysm with severe calcification]." 03/01/2022 - "We propose an alternative strategy for the treatment of ascending aortic aneurysm and aortic valve pathology with the use of a sutureless, collapsible, stent-mounted aortic valve prosthesis."
3.	Replantation 01/01/2023 - "66 Patients with ascending aortic aneurysm (mean aortic diameter 57 +/- 10 mm) and aortic valve-sparing surgery (32 reimplantation technique (David), 34 remodeling technique (Yacoub)) were routinely investigated by Doppler echocardiography. " 01/01/2020 - "The aim of our investigation was to assess the remote results of valve-sparing aortic root reimplantation into the graft (Florida Sleeve technique) compared with reimplantation of the aortic valve into the graft (David technique) during surgical correction of ascending aortic aneurysms accompanied by concomitant aortic insufficiency. " 01/01/2018 - "Valve reimplantation or prosthetic valve replacement may not be ideal for these patients, and ascending aortic aneurysm resection with aortic valve repair using geometric internal ring annuloplasty is a simple, successful, and reproducible alternative treatment approach. " 01/01/2016 - "Older patients with ascending aortic aneurysm and aortic insufficiency secondary to dilated sinotubular junction and a normal aortic annulus can be treated with remodeling of the aortic root or with reimplantation of the aortic valve. " 01/01/2015 - "The authors herein describe and analyse their experience in performing reimplantation of the aortic valve in patients with ascending aortic aneurysm and concomitant aortic insufficiency. "
4.	Operative Surgical Procedures 12/01/2016 - "Patients with ascending aortic aneurysm undergoing complex surgical procedures are at increased risk of early postoperative excessive blood loss. " 10/01/2014 - "To examine the influence of different surgical procedures on clinical outcome in patients undergoing aortic root replacement for ascending aorta aneurysm (AAA) with or without concomitant aortic valve regurgitation (AR). " 09/01/2004 - "Replacement of the ascending aorta with a prosthetic graft is the preferred surgical procedure for an ascending aortic aneurysm. " 01/01/1991 - "Five to fifteen percent of patients undergoing aortic valve replacement (AVR) will have an ascending aortic aneurysm requiring a concomitant surgical procedure. " 11/01/2022 - "We aimed to study sex differences in aortopathy and valve disease among patients undergoing aortic valve replacement and/or surgical procedure for ascending aortic aneurysm and assess whether differences are specific for patients with bicuspid aortic valve (BAV) compared with patients with tricuspid aortic valve. "
5.	Therapeutics 01/01/2022 - "The aim of the present study was to investigate whether ASA therapy is associated with a lower prevalence of ascending aortic aneurysm in a surgical cohort. " 11/01/1978 - "Selected therapy for ascending aortic aneurysms." 01/24/2022 - "Metformin therapy is not associated with the lower prevalence of ascending aortic aneurysm in diabetic patients." 07/15/2015 - "Effects of statin therapy on ascending aorta aneurysms growth: A propensity-matched analysis." 02/01/1976 - "A safe method in therapy of the ascending aortic aneurysm by partial resection and reconstruction combined with reinforcement by a nylon net is described. "