Abstract | BACKGROUND: METHODS: A total of 76 variables from 125 patients with ascending aortic aneurysms were collected from (1) blood plasma to measure plasma levels of miRNAs and protein activity; (2) computational flow analysis to estimate peak systolic WSS and time-average WSS (TAWSS); and (3) imaging analysis of computed tomography angiography to determine aortic wall strain. Principal component analysis followed by logistic regression allowed the development of a predictive model of aortic surgery by combining biomechanical descriptors and biomarkers. RESULTS: The protein activity of MMP-1, TIMP-1, and MMP-2 was positively correlated to the systolic WSS and TAWSS observed in the proximal ascending aorta (eg, R = 0.52, P < .001, for MMP-1 with TAWSS) where local maxima of WSS were found. For bicuspid patients, aortic wall strain was associated with miR-26a (R = 0.55, P = .041) and miR-320a (R = 0.69, P < .001), which shows a significant difference between bicuspid and tricuspid patients. Receiver-operating characteristics curves revealed that the combination of WSS, MMP-1, TIMP-1, and MMP-12 is predictive of aortic surgery (area under the curve 0.898). CONCLUSIONS:
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Authors | Salvatore Pasta, Valentina Agnese, Alessia Gallo, Federica Cosentino, Marzio Di Giuseppe, Giovanni Gentile, Giuseppe M Raffa, Joseph F Maalouf, Hector I Michelena, Diego Bellavia, Pier Giulio Conaldi, Michele Pilato |
Journal | The Annals of thoracic surgery
(Ann Thorac Surg)
Vol. 110
Issue 5
Pg. 1595-1604
(11 2020)
ISSN: 1552-6259 [Electronic] Netherlands |
PMID | 32289298
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | Copyright © 2020 The Society of Thoracic Surgeons. Published by Elsevier Inc. All rights reserved. |
Chemical References |
- Biomarkers
- MicroRNAs
- Tissue Inhibitor of Metalloproteinase-1
- Matrix Metalloproteinase 12
- Matrix Metalloproteinase 1
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Topics |
- Adult
- Aged
- Aorta
(physiopathology)
- Aortic Aneurysm, Thoracic
(blood, physiopathology, surgery)
- Aortic Valve
(abnormalities, physiopathology)
- Bicuspid Aortic Valve Disease
(surgery)
- Biomarkers
- Female
- Humans
- Logistic Models
- Male
- Matrix Metalloproteinase 1
(blood)
- Matrix Metalloproteinase 12
(blood)
- Mechanotransduction, Cellular
- MicroRNAs
(blood)
- Middle Aged
- Stress, Mechanical
- Tissue Inhibitor of Metalloproteinase-1
(blood)
- Vascular Remodeling
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