Renin Inhibitors

01/01/2007 - "Renin inhibitors can prevent blood vessel constriction and therefore could be useful for the treatment of hypertension. "
01/01/2010 - "Furthermore, publication of the AVOID and ALLAY studies has proved a real novelty in the treatment of hypertension; they provided evidence for the safety and efficacy of a new family of drugs: the direct renin inhibitors. "
01/01/2014 - "Renin inhibitors in diabetes and hypertension: an update."
01/01/2014 - "Direct renin inhibitors (DRIs) have increasingly shown a significant advantage in the treatment of hypertension and protection of target organs. "
06/01/2013 - "Direct renin inhibitors (DRIs) are therefore considered attractive agents for the treatment of hypertension. "

01/01/2017 - "We included randomized, double-blinded, placebo-controlled studies evaluating BP lowering efficacy of fixed-dose monotherapy with renin inhibitor compared with placebo for a minimum duration of three to 12 weeks in adult patients with primary hypertension. "
08/01/2009 - "We conducted a systematic review and meta-analysis of double-blind randomized controlled trials to quantify the dose-related systolic (SBP) and diastolic blood pressure (DBP) lowering efficacy of renin inhibitors vs placebo in the treatment of adults with primary hypertension. "
01/01/2018 - "The Efficacy of Renin Inhibitors in Primary Hypertension."
01/01/2017 - "Blood pressure lowering efficacy of renin inhibitors for primary hypertension."
08/01/2009 - "Blood pressure lowering efficacy of renin inhibitors for primary hypertension: a Cochrane systematic review."

08/01/2022 - "The current meta-analysis was carried out to assess the efficacy of direct renin inhibitors in preventing the progression of diabetic kidney disease. "
08/01/2022 - "Efficacy of Direct Renin Inhibitors in Slowing Down the Progression of Diabetic Kidney Disease: A Meta-Analysis."
01/01/2020 - "The purpose of this systematic review was to investigate the scientific evidence to support the use of direct renin inhibitors (DRIs) in diabetic nephropathy (DN). "
01/01/2019 - "Imarikiren is a novel, potent, and selective direct renin inhibitor that has shown high oral availability during clinical development for the treatment of diabetic nephropathy. "
07/01/2014 - "Update on role of direct renin inhibitor in diabetic kidney disease."

03/01/2010 - "Several ongoing clinical studies will probably clarify the role of renin inhibitors in heart failure. "
01/01/2020 - "Our results suggest that this newly generated triple-tg heart failure model is useful to evaluate the cardioprotective effects of human renin inhibitors at clinically relevant doses, thereby minimizing the concerns of off-target effects related to much higher drug exposure than that achieved in clinical study."
03/01/2013 - "Direct renin inhibitor; Echocardiography; Heart failure."
03/01/2013 - "AT1 receptor, MMP-2 and MMP-9 levels were increased in the heart failure-only model while direct renin inhibitor attenuated this significantly. "
01/01/1996 - "Renin inhibitors given parenterally safely lower blood pressure in patients with essential heart failure. "

09/01/2009 - "Application of 3D QSAR CoMFA/CoMSIA and in silico docking studies on novel renin inhibitors against cardiovascular diseases."
04/01/2010 - "[Direct renin inhibitors in cardiovascular disease management: opportunities and perspectives]."
09/01/2009 - "The utility of renin inhibitors in the treatment of cardiovascular diseases has not been fully explored yet. "
07/01/2000 - "These renin inhibitors are therefore potential therapeutic agents for the treatment of hypertension and related cardiovascular diseases."
06/19/2014 - "This explains why AT1 receptor blockers (ARBs) and inhibitors of Ang II synthesis, such as ACE inhibitors and renin inhibitors, are beneficial for cardiovascular disease. "