The angiotensin II type 2 receptor for pain control.

Abstract

All well-known deleterious effects of angiotensin (Ang) II, including vasoconstriction, inflammation, water and salt retention, and vascular remodeling, are mediated via its type 1 (AT1) receptor. This explains why AT1 receptor blockers (ARBs) and inhibitors of Ang II synthesis, such as ACE inhibitors and renin inhibitors, are beneficial for cardiovascular disease. Yet, Ang II has a second receptor, the Ang II type 2 (AT2) receptor, the function of which, even after over 20 years of research, remains largely unknown. In this issue, Marion et al. provide a new chapter to the AT2 receptor story.

• Authors: A H Jan Danser, Praveen Anand
• Journal: Cell (Cell) Vol. 157 Issue 7 Pg. 1504-6 (Jun 19 2014) ISSN: 1097-4172 [Electronic] United States
• PMID: 24949962 (Publication Type: Journal Article, Comment)
• Copyright: Copyright © 2014 Elsevier Inc. All rights reserved.

Chemical References

• Angiotensins
• Macrolides
• mycolactone

Topics

• Angiotensins (metabolism)
• Animals
• Buruli Ulcer (pathology)
• Humans
• Macrolides (isolation & purification)
• Mycobacterium ulcerans