Exercise-Induced Allergies

Allergic reactions following a period of exercise. Elevated serum HISTAMINE and TRYPTASE levels and cutaneous MAST CELL degranulation are often associated with post-exertional allergic reactions which sometimes are triggered only in combination with prior consumption of a specific food such as wheat. Allergic symptoms produced post-exercise range from skin eruption, asthma, bronchospasm, and anaphylaxis.

Also Known As:

Allergic Reaction, Post-Exertional; Allergic Reactions, Post-Exertional; Allergy, Exercise-Induced; Allergy, Food-Dependent Exercise-Induced; Anaphylaxis, Exercise-Induced; Anaphylaxis, Wheat-Dependent Exercise-Induced; Exercise Induced Allergies; Exercise Induced Anaphylaxis; Exercise Induced Anaphylaxis and Urticaria; Exercise Induced Urticaria; Exercise-Induced Allergy; Exercise-Induced Allergy, Food-Dependent; Exercise-Induced Anaphylaxi, Wheat-Dependent; Exercise-Induced Anaphylaxis, Wheat-Dependent; Exercise-Induced Urticarias; Food Dependent Exercise Induced Allergies; Food-Dependent Exercise-Induced Allergy; Post Exertional Allergic Reactions; Post-Exertional Allergic Reaction; Urticaria, Exercise-Induced; Wheat Dependent Exercise Induced Anaphylaxis; Exercise-Induced Anaphylaxis; Exercise-Induced Anaphylaxis and Urticaria; Exercise-Induced Urticaria; Food-Dependent Exercise-Induced Allergies; Post-Exertional Allergic Reactions; WDEIA; Wheat-Dependent Exercise-Induced Anaphylaxis

Networked: 298 relevant articles (11 outcomes, 23 trials/studies)

Relationship Network

Disease Context: Research Results

Immune System Diseases: 4321
- Hypersensitivity: 76867
  - Immediate Hypersensitivity: 2249
    - Exercise-Induced Allergies: 298
      - Exercise-Induced Asthma: 781

Related Diseases

1.	Exercise-Induced Allergies
2.	Anaphylaxis (Anaphylactic Shock)
3.	Hypersensitivity (Allergy)
4.	Urticaria (Hives)
5.	Chronic Urticaria

Experts

1.	Matsuo, Hiroaki: 24 articles (04/2021 - 03/2004)
2.	Morita, Eishin: 23 articles (04/2021 - 03/2004)
3.	Chinuki, Yuko: 12 articles (04/2021 - 12/2009)
4.	Hide, Michihiro: 9 articles (01/2021 - 12/2011)
5.	Kohno, Kunie: 9 articles (10/2016 - 03/2004)
6.	Yokooji, Tomoharu: 8 articles (04/2021 - 12/2013)
7.	Brockow, Knut: 7 articles (01/2022 - 04/2015)
8.	Morita, E: 7 articles (08/2012 - 11/2000)
9.	Takahashi, Hitoshi: 6 articles (10/2016 - 12/2009)
10.	Hiragun, Makiko: 6 articles (04/2015 - 12/2011)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Exercise-Induced Allergies:

1.	Cholinergic Agents (Cholinergics)IBA 04/18/1986 - "The data derived from the study of two representative patients, one with cholinergic urticaria and the other with exercise-induced anaphylaxis, suggest approaches to distinguishing these diagnoses. " 07/01/2020 - "Examples of these reactions include exercise-induced anaphylaxis (EIA) and cholinergic urticaria (ChoIU). " 07/01/2020 - "Clinical Management of Exercise-Induced Anaphylaxis and Cholinergic Urticaria." 01/01/2015 - "Cholinergic urticaria and exercise-induced anaphylaxis." 10/01/2013 - "We also present a detailed FDEIAn definition along with etiologic factors and medical treatment for cholinergic urticaria (UC) and exercise-induced anaphylaxis (EIA). "
2.	Omalizumab (Xolair)FDA Link 07/01/2023 - "We aimed to evaluate efficacy and safety of long-term omalizumab treatment for adult patients with WDEIA. " 01/01/2023 - "Severe exercise-induced anaphylaxis in a hot and humid area successfully treated with omalizumab: a case report." 10/01/2017 - "Long-term omalizumab use in the treatment of exercise-induced anaphylaxis." 01/01/2017 - "Successful treatment with omalizumab in challenge confirmed exercise-induced anaphylaxis." 01/01/2013 - "Successful treatment with omalizumab was recently reported in a case of refractory exercise-induced anaphylaxis."
3.	Histamine Antagonists (Antihistamines)IBA 12/01/2007 - "Antihistamine and sodium cromoglycate medication for food cold water exercise-induced anaphylaxis." 10/15/2001 - "Management of acute episodes of exercise-induced anaphylaxis includes cessation of exercise, administration of epinephrine and antihistamines, vascular support and airway maintenance. " 11/01/1996 - "Prophylactic antihistamines are more effective for cholinergic urticaria than for exercise-induced anaphylaxis." 11/01/1996 - "Prophylactic antihistamines are more effective for cholinergic urticaria than for exercise-induced anaphylaxis."
4.	AllergensIBA 08/01/2021 - "This study shows the alternative role of BAT in better defining WDEIA and the causative wheat allergens. " 09/01/2013 - "Using WDEIA as a model disease, studies demonstrated that exercise increases skin prick test reactivity to and bioavailability of the allergen. " 05/01/2012 - "The aim of this study was to evaluate the performance of an allergen microarray in the detection of sIgE against ω-5-gliadin in 10 patients with suspected WDEIA and high levels of sIgE against ω-5-gliadin (mean: 9.31±7.53 kU/L, range: 4.24-25.8) as measured by FEIA. " 05/01/1999 - "The aim of the study was to characterize the allergens involved in wheat-dependent, exercise-induced anaphylaxis and to describe the clinical outcome in a series of 18 adult patients. " 02/01/1997 - "The purpose of the present study was to analyse the allergens in cereals responsible for the severe anaphylactic symptoms and to verify the test methods suitable for screening the patients with cereal dependent exercise-induced anaphylaxis. "
5.	Immunoglobulin E (IgE)IBA 07/01/2022 - "We evaluated specific immunoglobulin E (sIgE) reactivity of the ω5D in WDEIA patients compared to wild-type cultivar. " 01/01/2019 - "FA/WDEIA patients showed higher specific IgE values to Tri tu 14 and Pru p 3 than BA patients. " 01/01/2019 - "Among 25 Tri a 14 CAP positive sera, 23 (92%) were reactive to wheat extract, 22 (88%) to Tri tu 14 and 20 (80%) to Pru p 3. The correlation between Tri a 14 and Tri tu 14 specific IgE levels was r = 0.97 (BA) and r = 0.93 (FA/WDEIA), respectively. " 10/28/2015 - "Sera from 7 of 11 WDEIA patients showed greatly reduced levels of immunoglobulin E (IgE) reactivity to ω5-gliadins in both transgenic lines. " 05/01/2013 - "Food-dependent exercise-induced anaphylaxis (FDEIA) by nectarine in a paediatric patient with weakly positive nectarine prick-by-prick and negative specific IgE to Pru p 3."
6.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 06/01/2013 - "Second, diagnoses were made using retests and/or dietary management in Group II and III. Positive results for wheat plus exercise and/or aspirin challenge tests gave a diagnosis of definite WDEIA in 17 of 36 patients (Group I). " 07/01/2020 - "The most common medicines associated with drug-dependent exercise-induced anaphylaxis are the nonsteroidal anti-inflammatory drugs including aspirin." 01/01/2019 - "To investigate the role and impact of different cofactors (exercise, aspirin, and alcohol) in patients with WDEIA. " 11/01/2017 - "Aspirin is an enhancing factor for food-dependent exercise-induced anaphylaxis in children." 09/01/2012 - "Limited influence of aspirin intake on mast cell activation in patients with food-dependent exercise-induced anaphylaxis: comparison using skin prick and histamine release tests."
7.	Glutens (Glutelin)IBA 10/01/2023 - "This article provides an overview of current knowledge on the diagnosis and management of WDEIA including an optimized challenge protocol using wheat gluten and cofactors." 01/01/2022 - "Basophil Activation to Gluten and Non-Gluten Proteins in Wheat-Dependent Exercise-Induced Anaphylaxis." 08/01/2021 - "The basophil activation test differentiates between patients with wheat-dependent exercise-induced anaphylaxis and control subjects using gluten and isolated gluten protein types." 03/01/2018 - "A challenge test with gluten at rest and combined exercise is a safe confirmatory test for WDEIA. " 04/01/2015 - "Oral challenge with gluten alone or along with ASA and alcohol is a sensitive and specific test for the diagnosis of WDEIA. "
8.	Proteins (Proteins, Gene)FDA Link 01/30/2020 - "For WDEIA, protein spots around 37 kDa (pH 6-9) and 37-50 kDa (pH 5-6) were identified. " 01/01/2020 - "Wheat-dependent exercise-induced anaphylaxis in Chinese people: a clinical research on 33 cases with antigenic analysis of wheat proteins." 10/01/2015 - "Differentiating hydrolyzed wheat protein wheat-dependent exercise-induced anaphylaxis from conventional wheat-dependent exercise-induced anaphylaxis is important owing to their severity and similarities. " 10/01/2015 - "Therefore, we diagnosed hydrolyzed wheat protein wheat-dependent exercise-induced anaphylaxis. " 10/01/2015 - "Diagnosis and long-term management of hydrolyzed wheat protein wheat-dependent exercise-induced anaphylaxis."
9.	Soaps (Soap)IBA 09/01/2012 - "Remission of wheat-dependent exercise-induced anaphylaxis after the cessation of hydrolysed wheat-containing soap usage." 09/01/2013 - "The development of HWP-WDEIA is associated with the use of HWP-soap. " 09/01/2013 - "Among 36 patients with WDEIA, 30 patients had used only one type of HWP-soap. " 09/01/2013 - "To clarify the relation between WDEIA and HWP-containing soap and their prognosis, we retrospectively studied the patients who visited Hiroshima University Hospital and were diagnosed as WDEIA from January 2010 to June 2011. " 02/01/2013 - "We enrolled 7 patients with wheat-dependent exercise-induced anaphylaxis who had been sensitized to HWP primarily through the percutaneous and/or the rhinoconjunctival route by using facial soap containing HWP. "
10.	Cromolyn Sodium (Cromoglicic Acid)FDA LinkGeneric 09/01/1983 - "Exercise-induced urticaria and angio-oedema with relief from cromoglycate insufflation." 11/01/2009 - "Food-dependent exercise-induced anaphylaxis (FDEIA) was prevented from recurring in 2 children by sodium cromoglycate (SCG) before intake of the causative food. " 11/01/2009 - "Effect of oral sodium cromoglycate in 2 children with food-dependent exercise-induced anaphylaxis (FDEIA)." 05/01/1994 - "Effectiveness of disodium cromoglycate in food-dependent, exercise-induced anaphylaxis: a case report." 12/01/2007 - "Antihistamine and sodium cromoglycate medication for food cold water exercise-induced anaphylaxis."

Therapies and Procedures

1.	Immunotherapy 07/01/2023 - "The most common triggers were food (68%), drugs (12%), food-dependent exercise-induced anaphylaxis (5%), insects (4%), and oral immunotherapy (3%), with drugs being the most common in-hospital trigger and food being the most common out-of-hospital trigger. " 01/01/2022 - "The most common triggers were food (68%), drugs (12%), food-dependent exercise-induced anaphylaxis (5%), insects (4%), and oral immunotherapy (3%), with drugs being the most common in-hospital trigger and food being the most common out-of-hospital trigger. " 11/01/2020 - "An interesting association between food-dependent exercise-induced anaphylaxis (FDEIA) and oral immunotherapy (OIT) has recently been reported. " 01/01/2020 - "[CHARACTERISTICS OF THE SYMPTOMS DURING FOOD AND EXERCISE PROVOCATION TESTS IN PATIENTS AFTER ORAL IMMUNOTHERAPY: COMPARISON WITH FOOD-DEPENDENT EXERCISE-INDUCED ANAPHYLAXIS]." 01/01/2014 - "A case of wheat-dependent exercise-induced anaphylaxis after specific oral immunotherapy."
2.	Therapeutics 12/01/2013 - "These findings could be useful to help develop tools for diagnosis and desensitization therapy for HWP-WDEIA." 10/01/2001 - "Two cases of FDEIA are presented, and the diagnosis, pathophysiology and therapy of food-dependent exercise-induced anaphylaxis are reviewed." 10/09/2021 - "To our knowledge, this is the first report of an exercise-induced anaphylaxis due to isotretinoin therapy. " 03/01/2014 - "Exercise-induced anaphylaxis in a cardiopathic patient on chronic aspirin therapy." 03/01/2008 - "Food-dependent exercise-induced anaphylaxis induced by low dose aspirin therapy."
3.	Gluten-Free Diet 01/01/2016 - "The most reliable prophylaxis of WDEIA is a gluten-free diet. "
4.	Tooth Extraction (Tooth Extractions) 03/01/2023 - "A Case of Tooth Extraction in a Patient with Food-Dependent Exercise Induced Anaphylaxis." 03/01/2023 - "A 29-year-old Japanese man with food-dependent exercise-induced anaphylaxis (FDEIA) underwent tooth extraction under general anesthesia. "
5.	Intramuscular Injections 09/01/2019 - "A 62-year-old woman with food-dependent exercise-induced anaphylaxis developed ACS after intramuscular injection of adrenaline for the treatment of anaphylaxis, whereas administered aspirin for the treatment of ACS exacerbated anaphylaxis. "