Effectiveness of disodium cromoglycate in food-dependent, exercise-induced anaphylaxis: a case report.

Abstract

An 18-year-old girl experienced anaphylactic reactions three times and frequent urticaria with exercise after meals that included wheat. Allergy evaluation showed a strong prick test reaction to wheat, and RAST score was 2 for wheat. Exercise provoked a decrease of FEV1 of 7.4% and increase of plasma histamine with no symptoms. Exercise after eating wheat provoked an FEV1 decrease of more than 18.7%, further increase of plasma histamine, urticaria and mild dyspnea. Oral administration of disodium cromoglycate before ingestion of bread and exercise challenge caused a maximal FEV1 increase of 6%, no increase of the plasma histamine, and no symptoms.

• Authors: F Juji, M Suko
• Journal: Annals of allergy (Ann Allergy) Vol. 72 Issue 5 Pg. 452-4 (May 1994) ISSN: 0003-4738 [Print] United States
• PMID: 8179233 (Publication Type: Case Reports, Journal Article)

Chemical References

• Histamine
• Cromolyn Sodium

Topics

• Adolescent
• Anaphylaxis (etiology, prevention & control)
• Cromolyn Sodium (therapeutic use)
• Exercise
• Female
• Food Hypersensitivity (complications)
• Forced Expiratory Volume
• Histamine (blood)
• Humans
• Urticaria (etiology)