Filaggrin Proteins

S100 proteins that aggregate KERATINS. Filaggrin precursor proteins are localized in keratohyalin granules and processed into individual functional filaggrin molecules during terminal epidermis differentiation. Mutations in fillagrins are associated with ICHTHYOSIS VULGARIS.

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Networked: 950 relevant articles (18 outcomes, 91 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	McLean, W H Irwin: 55 articles (12/2018 - 03/2006)
2.	Irvine, Alan D: 45 articles (01/2020 - 03/2006)
3.	Sandilands, Aileen: 29 articles (07/2014 - 03/2006)
4.	Thyssen, Jacob P: 28 articles (01/2020 - 02/2010)
5.	Thyssen, J P: 25 articles (01/2020 - 03/2010)
6.	Menné, Torkil: 22 articles (08/2017 - 11/2008)
7.	Weidinger, Stephan: 21 articles (06/2022 - 07/2006)
8.	Campbell, Linda E: 20 articles (04/2016 - 03/2006)
9.	Johansen, J D: 19 articles (05/2018 - 03/2010)
10.	Leung, Donald Y M: 18 articles (01/2022 - 07/2007)

Related Diseases

1.	Inflammation (Inflammations) 01/01/2017 - "In this study we show that in the filaggrin mutant mouse model of spontaneous AD, IL-17RA deficiency (Il17ra-/- ) resulted in severe exacerbation of skin inflammation. " 01/01/2015 - "The objective of this study was to investigate whether a single defect in skin barrier function simulated by filaggrin silencing could induce Th2-predominant inflammation. " 06/01/2022 - "Loss-of-function mutations in the filaggrin (FLG) gene directly alter skin barrier function and critically influence atopic inflammation. " 04/01/2021 - "The complex pathological mechanism behind AD etiology is epidermal barrier destruction resulting in the lack of filaggrin protein that can induce inflammation and T-cell infiltration. " 02/01/2021 - "This inflammation then downregulates the expression of filaggrin in keratinocytes and exacerbates epidermal barrier dysfunction. "
2.	Atopic Dermatitis (Atopic Eczema) 12/01/2011 - "Knowledge of the existence of filaggrin (FLG) gene mutations might be helpful for a subclassification of patients with atopic dermatitis (AD) which can be used to introduce individualized treatments. " 11/01/2023 - "Filaggrin gene polymorphisms in Indian children with atopic dermatitis: A cross-sectional multicentre study." 07/01/2021 - "This study is the first to report that PN causes an increase in filaggrin transcription and production, and these results suggest that PN-induced filaggrin production may be a useful target as a daily care component in atopic dermatitis, wherein filaggrin levels are specifically reduced." 01/01/2021 - "This study aimed to analyze the gender-specific association of the filaggrin (FLG) gene polymorphisms with atopic dermatitis (AD) in Caucasians from the central region of Russia. " 09/01/2020 - "Numerous candidate gene association studies, genome-wide association studies, studies on copy number variations and most recently, sequencing studies, have confirmed the robust association of mutations in the Filaggrin gene with atopic dermatitis, and have also linked these mutations with several other disorders. "
3.	Eczema 11/01/2008 - "Furthermore, we suggest future studies of atopic hand eczema to analyse for the filaggrin mutations. " 01/01/2008 - "Recent studies have identified 2 loss-of-function variants, R501X and 2282del4, in the filaggrin gene as predisposing factors in the development of eczema. " 11/03/2023 - "Identification of eczema clusters and their association with filaggrin and atopic comorbidities: analysis of five birth cohorts." 02/01/2023 - "Genetic variants in filaggrin (FLG) are key in eczema and are less common in Africans than in Europeans and Asians. " 12/31/2022 - "We aimed to explore if reduced skin barrier function by high transepidermal water loss (TEWL), or manifestations of eczema or Filaggrin (FLG) mutations, were associated with lower lung function in three-month-old infants. "
4.	Dermatitis 03/01/2012 - "The natural history of individuals with the filaggrin null genotype is fairly good in the sense that they may not develop dermatitis at all, and if they do, they may experience complete remission." 03/01/2012 - "Individuals who are homozygous for the 2282del4 and R501X filaggrin null mutations do not always develop dermatitis and complete long-term remission is possible." 08/01/2017 - "Only a few studies have investigated whether individuals with loss-of-function filaggrin gene (FLG) mutations, who often have severe and early onset of dermatitis, experience occupational consequences. " 03/01/2012 - "No studies have investigated whether individuals with the homozygous filaggrin null genotype always develop dermatitis. " 03/23/2022 - "We also investigated the effects of the topical application of an ERK inhibitor on the dermatitis score, transepidermal water loss (TEWL), histological change, and expression of filaggrin, using an AD-like NC/Nga murine model. "
5.	Skin Diseases (Skin Disease) 02/01/2011 - "Therefore, the findings of this study show that reduced filaggrin levels may influence innate immune responses via TLR stimuli and may contribute to the pathogenesis of inflammatory skin disease via TSLP expression." 08/01/2022 - "The filaggrin gene (FLG) plays a role in skin diseases, with the skin barrier function being impaired in FLG null carriers. " 01/01/2021 - "Here, the roles and biology of filaggrin, related skin diseases, and a therapeutic strategy targeting filaggrin are reviewed. " 05/01/2017 - "To investigate whether patients with OLP/OLL have (i) altered distribution of filaggrin in the oral mucosa; (ii) a higher incidence of mutations in the filaggrin gene (FLG); (iii) active dermatoses, apart from cutaneous LP, than healthy controls; and (iv) patients with OLP/OLL and a defect in the FLG have more widespread oral lesions and report more symptoms than OLP/OLL patients without a concomitant defect in the FLG. " 02/10/2016 - "Moreover, we observed that the skin barrier protein filaggrin, insufficiency of which is associated with atopic skin disease, inhibited PLA2 activity and decreased CD1a-reactive PLA2-generated neolipid-specific T cell activity from skin and blood. "

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