Reelin Protein

It is an EXTRACELLULAR MATRIX serine protease that plays an important role in the development of the central nervous system. It regulates neuronal migration and microtubule function.

Also Known As:

Networked: 29 relevant articles (0 outcomes, 6 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Yamada, Kiyofumi: 2 articles (02/2022 - 01/2020)
2.	Gavín, Rosalina: 2 articles (01/2020 - 10/2017)
3.	Hattori, Mitsuharu: 2 articles (01/2020 - 01/2020)
4.	Kohno, Takao: 2 articles (01/2020 - 01/2020)
5.	Llorens, Franc: 2 articles (01/2020 - 10/2017)
6.	Urrea, Laura: 2 articles (01/2020 - 10/2017)
7.	Zerr, Inga: 2 articles (01/2020 - 10/2017)
8.	Wang, Yi: 2 articles (01/2019 - 05/2012)
9.	Mizoguchi, Hiroyuki: 1 article (02/2022)
10.	Nakai, Tsuyoshi: 1 article (02/2022)

Related Diseases

1.	Schizophrenia (Dementia Praecox) 01/01/2015 - "We conclude that the reelin protein blood concentration might be a relevant signal with respect to the pathophysiology of schizophrenia." 01/01/2011 - "Post-mortem studies have shown lower reelin protein levels in the brains of patients with schizophrenia and bipolar disorder compared with controls. " 03/05/2010 - "Post-mortem studies have shown lower Reelin protein levels in the brains of patients with schizophrenia and bipolar disorder (BP) compared with controls. " 06/01/2004 - "In addition, reelin protein in the molecular layer of the dentate gyrus was decreased in schizophrenia, bipolar disorder, and depression at the trend level of statistical significance (P=0.065). " 05/15/2004 - "This gene's protein Reelin, which is necessary for neuronal migration and synaptogenesis, is reduced in schizophrenia and bipolar disorder, suggesting hypermethylation of the promoter region in these disorders. "
2.	Bipolar Disorder (Manic Depressive Psychosis) 01/01/2011 - "Post-mortem studies have shown lower reelin protein levels in the brains of patients with schizophrenia and bipolar disorder compared with controls. " 03/05/2010 - "Post-mortem studies have shown lower Reelin protein levels in the brains of patients with schizophrenia and bipolar disorder (BP) compared with controls. " 06/01/2004 - "In addition, reelin protein in the molecular layer of the dentate gyrus was decreased in schizophrenia, bipolar disorder, and depression at the trend level of statistical significance (P=0.065). " 05/15/2004 - "This gene's protein Reelin, which is necessary for neuronal migration and synaptogenesis, is reduced in schizophrenia and bipolar disorder, suggesting hypermethylation of the promoter region in these disorders. " 11/01/2000 - "We employed quantitative immunocytochemistry to measure levels of Reelin protein in various compartments of hippocampal formation in subjects diagnosed with schizophrenia, bipolar disorder and major depression compared to normal controls. "
3.	Mental Disorders (Mental Disorder) 02/06/2022 - "Clinical studies showed reductions in Reelin protein and mRNA expression levels in patients with psychiatric disorders; however, the causal relationship remains unclear. " 10/17/2016 - "The extracellular protein Reelin has an important role in neurological diseases, including epilepsy, Alzheimer's disease and psychiatric diseases, targeting hippocampal circuits. "
4.	Prion Diseases (Transmissible Spongiform Encephalopathies) 10/01/2017 - "With this is mind, in the present study, we determined that Reelin protein and mRNA levels increased in CJD human samples and in mouse models of human prion disease in contrast to murine models of prion infection. "
5.	Parkinson Disease (Parkinson's Disease) 01/01/2020 - "In this study, we analyzed brain levels of RELN mRNA and Reelin protein in post-mortem frontal cortex samples from different sporadic AD stages, Parkinson's disease with dementia (PDD), and Creutzfeldt-Jakob disease (sCJD), obtained from five different Biobanks. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Prions
3.	Protein Phosphatase 1
4.	Guanidine (Guanidine Nitrate)
5.	Brain-Derived Neurotrophic Factor (BDNF)
6.	Conditioned Culture Media
7.	Integrins
8.	Thyroxine (Levothyroxine)
9.	Proteins (Proteins, Gene)
10.	Methyltransferases

Related Therapies and Procedures

1.	Intraventricular Infusions