Reelin Regulates the Maturation of Dendritic Spines, Synaptogenesis and Glial Ensheathment of Newborn Granule Cells.

Abstract

Significance Statement:

The extracellular protein Reelin has an important role in neurological diseases, including epilepsy, Alzheimer's disease and psychiatric diseases, targeting hippocampal circuits. Here we address the role of Reelin in the development of synaptic contacts in adult-generated granule cells (GCs), a neuronal population that is crucial for learning and memory and implicated in neurological and psychiatric diseases. We found that the Reelin pathway controls the shapes, sizes, and types of dendritic spines, the complexity of multisynaptic innervations and the degree of the perisynaptic astroglial ensheathment that controls synaptic homeostasis. These findings show a pivotal role of Reelin in GC synaptogenesis and provide a foundation for structural circuit alterations caused by Reelin deregulation that may occur in neurological and psychiatric disorders.

• Authors: Carles Bosch, Nuria Masachs, David Exposito-Alonso, Albert Martínez, Cátia M Teixeira, Isabel Fernaud, Lluís Pujadas, Fausto Ulloa, Joan X Comella, Javier DeFelipe, Angel Merchán-Pérez, Eduardo Soriano
• Journal: Cerebral cortex (New York, N.Y. : 1991) (Cereb Cortex) Vol. 26 Issue 11 Pg. 4282-4298 (10 17 2016) ISSN: 1460-2199 [Electronic] United States
• PMID: 27624722 (Publication Type: Journal Article)
• Copyright: © The Author 2016. Published by Oxford University Press.

Chemical References

• Cell Adhesion Molecules, Neuronal
• Dab1 protein, mouse
• Disks Large Homolog 4 Protein
• Dlg4 protein, mouse
• Extracellular Matrix Proteins
• Nerve Tissue Proteins
• Reelin Protein
• Green Fluorescent Proteins
• Reln protein, mouse
• Serine Endopeptidases

Topics

• Animals
• Brain (cytology)
• Cell Adhesion Molecules, Neuronal (genetics, metabolism)
• Cell Differentiation
• Dendritic Spines (metabolism, ultrastructure)
• Disks Large Homolog 4 Protein (metabolism)
• Extracellular Matrix Proteins (genetics, metabolism)
• Green Fluorescent Proteins (genetics, metabolism)
• Imaging, Three-Dimensional
• Mice
• Mice, Inbred C57BL
• Mice, Transgenic
• Microscopy, Confocal
• Mutation (genetics)
• Nerve Tissue Proteins (deficiency, genetics, metabolism)
• Neurogenesis (physiology)
• Neuroglia (physiology)
• Neurons (physiology)
• Reelin Protein
• Serine Endopeptidases (genetics, metabolism)
• Signal Transduction (physiology)
• Synapses (physiology, ultrastructure)
• Transduction, Genetic