Designed Ankyrin Repeat Proteins

Genetically engineered antibody MIMETIC PROTEINS, derived from ANKYRIN PROTEINS. They offer advantages over antibodies because of their highly specific target PROTEIN BINDING with high affinity and specificity.

Also Known As:

DARPin; DARPins

Networked: 124 relevant articles (8 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Recombinant Proteins: 2754
    - Designed Ankyrin Repeat Proteins: 124
      - FSR16m synthetic protein
      - FSR22 synthetic protein
Technology, Industry, and Agriculture
- Manufactured Materials
  - Biomimetic Materials
    - Designed Ankyrin Repeat Proteins: 124
      - FSR16m synthetic protein
      - FSR22 synthetic protein

Experts

1.	Plückthun, Andreas: 28 articles (01/2022 - 11/2006)
2.	Deyev, Sergey: 12 articles (01/2022 - 10/2016)
3.	Schulga, Alexey: 11 articles (05/2022 - 10/2016)
4.	Vorobyeva, Anzhelika: 9 articles (05/2022 - 01/2018)
5.	Zangemeister-Wittke, Uwe: 9 articles (10/2019 - 09/2009)
6.	Tolmachev, Vladimir: 8 articles (05/2022 - 01/2018)
7.	Deyev, Sergey M: 7 articles (05/2022 - 01/2019)
8.	Konovalova, Elena: 7 articles (05/2022 - 02/2020)
9.	Orlova, Anna: 7 articles (01/2022 - 01/2018)
10.	Stumpp, Michael T: 7 articles (10/2021 - 03/2007)

Related Diseases

1.	Neoplasms (Cancer) 11/20/2013 - "Our data demonstrate the promise of the DARPin format for facile modular assembly of drug conjugates with improved pharmacokinetic performance for tumor targeting. " 04/01/2013 - "DARPin-targeted viruses were strongly attenuated in off-target tissue, thereby enhancing safety, but completely eliminated tumor xenografts. " 08/29/2023 - "The work described provides the preclinical foundation for DARPin-based bimodal NIRF/PA imaging of cancer." 02/23/2022 - "In vivo imaging of Alexa Fluor 647-dye conjugates in A431-xenografted mice bearing subcutaneous tumors as the SCC model revealed unspecific binding of bivalent DARPins to the ubiquitously expressed EGFR. " 01/01/2022 - "A Multispecific Anti-CD40 DARPin Construct Induces Tumor-Selective CD40 Activation and Tumor Regression."
2.	Infections 01/01/2023 - "In summary, we have shown that DARPins specific against SARS-CoV-2 translocate across intact airway epithelia and confer effective protection against infection and viral replication." 01/01/2022 - "Conditional expression of this DARPin reversibly impairs infection by IAV and Zika virus; moreover, SGs and aggresomes are downregulated. " 08/27/2010 - "The human CD4-specific DARPin 57.2 bound macaque CD4(+) cells and exhibited potent inhibitory activity against SIV infection in vitro. " 10/30/2009 - "Finally, phage infection assays demonstrated that TP901-1 infection of Lactococcus lactis cells was inhibited by each of the three selected DARPins. " 07/25/2008 - "These 2nd series DARPins potently inhibit infection of genetically divergent (subtype B and C) HIV isolates in the low nanomolar range, independent of coreceptor usage. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2022 - "Phase I Trial of 99mTc-(HE)3-G3, a DARPin-Based Probe for Imaging of HER2 Expression in Breast Cancer." 09/01/2021 - "Purified encapsulin-DARPin_miniSOG nanocompartments bind specifically to HER2 positive breast cancer cells and trigger apoptosis, indicating that the system is functional and specific. " 01/01/2021 - "Biparatopic designed ankyrin repeat proteins (bipDARPins) potently induce apoptosis in HER2-addicted breast cancer cell lines. " 09/01/2015 - "In vitro affinities of the panel of evolved DARPins directly correlated with the fluorescence intensities of evolved DARPins bound to HER2 on a breast cancer cell line. " 11/01/2021 - "After purging with EpCAM-targeted DARPin, all EpCAM-positive breast cancer cells were eradicated from the ovarian cortex. "
4.	Inflammation (Inflammations) 01/01/2022 - "Treatment with DARPin F7 inhibited neutrophil accumulation, reduced signs of local and systemic inflammation and improved survival in a mouse model of ARDS. " 01/01/2021 - "Thus, we conclude that ultrasound molecular imaging of inflammation using DARPin binders is feasible per se, but that screening of candidates cannot be accomplished with flow-chamber assays as used in our study." 01/01/2021 - "The activated Mac-1-specific DARPin F7 binds preferentially to activated monocytes, detects inflammation in critically ill patients, and inhibits monocyte and neutrophil function as an efficient new anti-inflammatory agent." 01/01/2021 - "Abicipar pegol, a designed ankyrin repeat protein (DARPin), demonstrated the ability to maintain stable visual acuity with 12-week dosing, but was not approved by the FDA due to higher than usual rates of intraocular inflammation. "
5.	Weight Loss (Weight Reduction) 01/01/2022 - "Treatment with F7 improved survival and reduced weight loss significantly compared to treatment with the control DARPin or PBS. " 06/28/2023 - "Animals that received DARPin F7 treatment suffered less weight loss and recovered from the weight loss more efficiently. "

Related Drugs and Biologics

1.	Epithelial Cell Adhesion Molecule
2.	Antigens
3.	Albumins
4.	Proteins (Proteins, Gene)
5.	Designed Ankyrin Repeat Proteins
6.	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)
7.	ErbB Receptors (EGF Receptor)
8.	human ERBB2 protein
9.	abicipar pegol
10.	Antibodies

Related Therapies and Procedures

1.	Therapeutics
2.	Intravitreal Injections
3.	Quantum Dots (Quantum Dot)
4.	Lasers (Laser)
5.	Intraocular Injections