Constitutive Androstane Receptor

A member of the nuclear receptor superfamily (subfamily 1, group I, member 3 [NR1i3]) involved, along with PREGNANE X RECEPTOR, in regulation of cellular responses to the exogenous and endogenous chemicals such as detoxification of XENOBIOTICS.

Also Known As:

Active Receptor, Constitutive; Androstane Receptor, Constitutive; Nuclear Receptor, CAR; Receptor, CAR Nuclear; Receptor, Constitutive Active; CAR Nuclear Receptor; CAR Orphan Nuclear Receptor; Constitutive Active Receptor; Constitutive Androstane Receptor beta

Networked: 183 relevant articles (8 outcomes, 21 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Cytoplasmic and Nuclear Receptors: 3987
    - Constitutive Androstane Receptor: 183

Experts

1.	Moore, David D: 10 articles (01/2019 - 06/2005)
2.	Negishi, Masahiko: 7 articles (01/2022 - 03/2007)
3.	Yamada, Tomoya: 7 articles (10/2021 - 04/2009)
4.	Lake, Brian G: 7 articles (01/2021 - 01/2009)
5.	Inoue, Kaoru: 7 articles (01/2016 - 01/2013)
6.	Kodama, Yukio: 7 articles (01/2016 - 01/2013)
7.	Takahashi, Miwa: 7 articles (01/2016 - 01/2013)
8.	Yoshida, Midori: 7 articles (01/2016 - 01/2013)
9.	Xie, Wen: 6 articles (01/2022 - 09/2009)
10.	Braeuning, Albert: 6 articles (01/2021 - 09/2011)

Related Diseases

1.	Fatty Liver 11/03/2022 - "In conclusion, DNLA was effective against alcohol-induced fatty liver disease, and the protection may be attributed to alleviated oxidative stress and restored metabolism homeostasis, probably through modulating nuclear receptor CAR-, PXR-, and Nrf2-mediated gene expression pathways." 11/03/2009 - "Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease." 01/01/2018 - "We showed that renal IR in mice induced fatty liver and compromised liver function through the downregulation of constitutive androstane receptor (CAR; -90.4%) and inhibition of hepatic very-low-density lipoprotein triglyceride (VLDL-TG) secretion (-28.4%). " 01/01/2021 - "Previously, we demonstrated that the PCB mixture, Aroclor1260, exacerbated NAFLD, reflective of toxicant-associated steatohepatitis, in diet-induced obese mice, in part through pregnane-xenobiotic receptor (PXR) and constitutive androstane receptor (CAR) activation. " 06/01/2018 - "Recent studies indicate a role for the constitutive androstane receptor (CAR), pregnane X-receptor (PXR), and hepatic xenobiotic detoxifying CYPs in fatty liver disease or obesity. "
2.	Neoplasms (Cancer) 10/01/2021 - "Application of humanized mice to toxicology studies: Evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)." 01/01/2022 - "(2021) titled "Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)"." 01/01/2022 - "(2021): Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR). " 01/01/2021 - "Many nongenotoxic chemicals have been shown to produce liver tumors in mice and/or rats by a mode of action (MOA) involving activation of the constitutive androstane receptor (CAR). " 01/01/2021 - "Critical evaluation of the human relevance of the mode of action for rodent liver tumor formation by activators of the constitutive androstane receptor (CAR)."
3.	Cholestasis 10/01/2020 - "Consistently, we found that constitutive androstane receptor (CAR) activation is crucial for the induction of the drug metabolic gene programme in cholestasis. " 05/01/2009 - "Pharmacological activation of the constitutive androstane receptor (CAR) protects the liver during cholestasis. " 10/01/2020 - "Transcriptomic analysis across liver diseases reveals disease-modulating activation of constitutive androstane receptor in cholestasis." 01/01/2010 - "These findings indicate that loss of Ostalpha provides protection from liver injury in obstructive cholestasis through adaptive responses in both the kidney and liver that enhance clearance of bile acids into urine and through detoxification pathways most likely mediated by the nuclear receptor Car." 11/14/2017 - "Pregnane X receptor and constitutive androstane receptor modulate differently CYP3A-mediated metabolism in early- and late-stage cholestasis."
4.	Non-Small-Cell Lung Carcinoma (Carcinoma, Non-Small Cell Lung) 11/01/2020 - "Hsa-miR-4271 downregulates the expression of constitutive androstane receptor and enhances in vivo the sensitivity of non-small cell lung cancer to gefitinib." 11/01/2020 - "In this study, we revealed the roles of the microRNA-4271/CAR (constitutive androstane receptor) axis in the regulation of the resistance to molecular anticancer targeting agents in non-small cell lung cancer (NSCLC) cells including two main categories of NSCLC: lung adenocarcinoma (AC) and large cell lung cancer (LCC). " 01/01/2014 - "Constitutive androstane receptor ligands modulate the anti-tumor efficacy of paclitaxel in non-small cell lung cancer cells."
5.	Ischemia 01/01/2018 - "Activation of Constitutive Androstane Receptor Ameliorates Renal Ischemia-Reperfusion-Induced Kidney and Liver Injury." 01/01/2012 - "The decrease in farnesoid X receptor, pregnane X receptor and constitutive androstane receptor in the liver after intestinal ischemia-reperfusion."

Related Drugs and Biologics

1.	Ligands
2.	Pregnane X Receptor
3.	Enzymes
4.	Cytochrome P-450 CYP3A
5.	Bile Acids and Salts (Bile Acids)
6.	Messenger RNA (mRNA)
7.	Glucocorticoid Receptors (Glucocorticoid Receptor)
8.	Retinoid X Receptor alpha
9.	Paclitaxel (Taxol)
10.	Glucocorticoids

Related Therapies and Procedures

1.	Fat-Restricted Diet (Diet, Fat Restricted)
2.	Therapeutics
3.	Hepatectomy
4.	Precision Medicine