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Mitochondrial Precursor Protein Import Complex Proteins

Multiprotein complexes that mediate import and sorting of mitochondrial preproteins into one of the four mitochondrial subcompartments: the outer membrane, the intermembrane space, the inner membrane, and the matrix. Mitochondrial protein import machinery includes translocase of the outer membrane (TOM) complex, translocases of the inner membrane (TIM) complex, beta‐barrel pathway complex, the mitochondrial intermembrane space import and assembly (MIA) pathway complex, carrier proteins of the inner membrane and the TIM23 complex and sorting and assembly machinery (SAM) complex.
Also Known As:
Import Complex, Mitochondrial; Preprotein Translocases, Mitochondrial; Translocase, TOM; Translocases, Mitochondrial Preprotein; MIA Complex; MIM Complex; Mitochondrial Import Complex; Mitochondrial Intermembrane Space Import and Assembly Complex; Mitochondrial Precursor Protein Import Machinery Proteins; Mitochondrial Preprotein Translocases; Mitochondrial Protein Import Machinery Proteins; SAM Complex; Sorting and Assembly Machinery Complex; TIM Complex; TIM23 Complex; TIMM Complex; TOM Channel; TOM Complex; TOM Translocase; TOMM Complex; TOMM Machinery; Translocase Outer Mitochondrial Membrane; Translocase of the Inner Membrane Complex; Translocase of the Inner Mitochondrial Membrane Complex; Translocase of the Outer Membrane Complex; Translocases of the Inner Membrane 23 Complex; Translocases of the Inner Membrane Complex
Networked: 17 relevant articles (0 outcomes, 2 trials/studies)

Bio-Agent Context: Research Results

Experts

1. Di Natale, Concetta: 2 articles (10/2018 - 12/2017)
2. Leone, Marilisa: 2 articles (10/2018 - 12/2017)
3. Marasco, Daniela: 2 articles (10/2018 - 12/2017)
4. Mercurio, Flavia Anna: 2 articles (10/2018 - 12/2017)
5. Pedone, Emilia Maria: 2 articles (10/2018 - 12/2017)
6. Pirone, Luciano: 2 articles (10/2018 - 12/2017)
7. Buchanan, Susan K: 1 article (11/2021)
8. Pitt, Ashley S: 1 article (11/2021)
9. Chaudhuri, Minu: 1 article (01/2021)
10. Quinones, Linda: 1 article (01/2021)

Related Diseases

1. Mitochondrial Diseases (Mitochondrial Disease)
01/17/2011 - "RNAi against two other putative members of the TOMM complex give similar phenotypes, implying that DAF-28 secretion is sensitive to mitochondrial dysfunction in general. "
10/05/2001 - "Thus, the pathomechanism underlying the Mohr-Tranebjaerg syndrome may involve an impaired biogenesis of the human TIM23 complex causing severe pleiotropic mitochondrial dysfunction."
12/01/2023 - "Tomm7 deficiency causes a unique alteration in mitochondrial function; despite the bioenergetic deficiency, mutant cells show increased oxygen consumption with normal responses to electron transport chain (ETC) inhibitors, suggesting that Tomm7 deficiency leads to an uncoupling between oxidation and ATP synthesis without impairing the function of the tricarboxylic cycle metabolism or ETC. This study presents evidence that a hypomorphic variant in one of the genes encoding a subunit of the TOM complex causes mitochondrial disease."
11/01/2021 - "Recent advances in our structural understanding of the TOM complex and the protein import machinery of the outer mitochondrial membrane have made structure-based therapeutics targeting outer mitochondrial membrane proteins during mitochondrial dysfunction an exciting prospect. "
01/01/2016 - "To date, many studies have suggested that these mitochondrial proteins, such as electron transport chain (ETC) complexes, uncoupling proteins (UCPs), mitochondrial dynamic proteins, translocases of outer membrane (Tom) complex, and mitochondrial permeability transition pore (MPTP), can directly or indirectly influence mitochondria-originated ROS production, consequently determining the degree of mitochondrial dysfunction and myocardial impairment. "
2. Malnutrition (Nutritional Deficiencies)
3. Neoplasms (Cancer)
4. Inflammation (Inflammations)
5. Atherosclerosis

Related Drugs and Biologics

1. Proteins (Proteins, Gene)
2. Mitochondrial Proteins (Mitochondrial Protein)
3. Adenosine Triphosphate (ATP)
4. Mitochondrial Permeability Transition Pore
5. Mitochondrial Uncoupling Proteins
6. Cytokines
7. Peptides (Polypeptides)
8. Hydrocarbons
9. hydroxide ion

Related Therapies and Procedures

1. Therapeutics