Mannose Receptor

A member of a family of endocytic receptors. Highly expressed on human macrophages, involved in regulating endocytosis, phagocytosis, and immune responses.

Also Known As:

206 Cluster, Differentiation; Antigen, CD206; Differentiation 206 Cluster; Mannose Fucose Receptor; Protein, MRC1; Receptor, Mannose-Fucose; CD206 Antigen; Cluster of Differentiation 206; MRC1 Protein; Mannose Receptors; Mannose-Fucose Receptor; Mannosyl-Fucosyl Receptor; Receptor, Mannose

Networked: 423 relevant articles (10 outcomes, 40 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Membrane Proteins: 10078
    - Cell Surface Receptors: 2125
      - Mannose Receptor: 423
  - Lectins: 6782
    - C-Type Lectins: 976
      - Mannose Receptor: 423
    - Mannose-Binding Lectins: 27
      - Mannose Receptor: 423

Experts

1.	Møller, Holger J: 10 articles (01/2021 - 01/2014)
2.	Raes, Geert: 9 articles (01/2022 - 08/2012)
3.	Møller, Holger Jon: 9 articles (01/2021 - 03/2014)
4.	Devoogdt, Nick: 8 articles (01/2021 - 08/2012)
5.	Lahoutte, Tony: 8 articles (01/2021 - 08/2012)
6.	Rødgaard-Hansen, Sidsel: 7 articles (05/2019 - 01/2014)
7.	Grønbæk, Henning: 6 articles (01/2021 - 04/2016)
8.	Møller, Søren: 5 articles (01/2021 - 01/2017)
9.	Grønbaek, Henning: 5 articles (01/2020 - 01/2017)
10.	Van Ginderachter, Jo A: 5 articles (11/2019 - 08/2012)

Related Diseases

1.	Chronic Obstructive Pulmonary Disease (COPD) 07/15/2008 - "Azithromycin improves macrophage phagocytic function and expression of mannose receptor in chronic obstructive pulmonary disease." 07/01/2012 - "We have previously shown that administration of low-dose azithromycin to subjects with COPD improved macrophage phagocytosis of apoptotic airway epithelial cells, reduced inflammation and increased expression of macrophage mannose receptor. " 07/15/2008 - "We investigated collectins (mannose-binding lectin [MBL] and surfactant protein [SP]-D) and mannose receptor (MR) in COPD and their possible role in the azithromycin-mediated improvement in phagocytosis. "
2.	Neoplasms (Cancer) 01/01/2013 - "These findings could be the first step towards a new treatment for solid organ cancers based on the role of the mannose receptor in C. " 01/01/2019 - "The histologic study of mouse tumor sections further verifies TPE-Man's excellent targeting specificity being comparable with the commercial mannose-receptor antibody. " 10/01/2023 - "Some tumor cells express more mannose receptor (MR) than healthy cells. " 01/01/2023 - "Tumor-associated macrophages (TAM) and cancer-associated fibroblasts (CAF), both of which are present in the stroma of intractable cancers, also express mannose receptors. " 11/01/2022 - "In the metastatic tumor, the myeloid-derived suppressor cell (MDSC) characteristic gene, mannose receptor C-type 1 (MRC1) and tumor associated macrophage 2 (TAM2)-related gene, were highly expressed. "
3.	Infections 02/07/2011 - "This study aims to characterize the mannose receptor (MR) gene in sheep and its role in ovine visna/maedi virus (VMV) infection. " 12/01/2001 - "Complex encounters at the macrophage-mycobacterium interface: studies on the role of the mannose receptor and CD14 in experimental infection models with Mycobacterium avium." 12/12/2022 - "All ER infected chickens also showed transient increased expression of mannose receptor MRC1L-B and decreased expression of major histocompatibility complex II on monocytes day 1 after infection indicating monocyte activation or relocation. " 01/01/2018 - "Mannose Receptor and the Mystery of Nonhealing Leishmania major Infection." 01/01/2018 - "Mannose receptor high, M2 dermal macrophages mediate nonhealing Leishmania major infection in a Th1 immune environment."
4.	Inflammation (Inflammations) 04/04/2023 - "Further studies in disease models with mannose receptor CD206-positive macrophages are warranted to clarify the tracer's potential for imaging of inflammation." 07/13/2023 - "The macrophage mannose receptor (RMM) is a crucial component of the immune system involved in immune responses, inflammation resolution, and tissue remodeling. " 06/26/2023 - "A Mannose Receptor from Litopenaeus vannamei Involved in Innate Immunity by Pathogen Recognition and Inflammation Regulation." 04/04/2023 - "In addition to being expressed on liver sinusoidal endothelial cells, mannose receptors are also found on antigen-presenting cells, including macrophages, which are mainly involved in the inflammation process. " 01/01/2018 - "Mannose receptor modulates macrophage polarization and allergic inflammation through miR-511-3p."
5.	Experimental Arthritis 05/01/2013 - "In this study, we investigated whether SPECT/micro-CT imaging with (99m)Tc-labeled Nanobodies directed against the macrophage mannose receptor (MMR) is a useful tool for monitoring and quantifying joint inflammation in collagen-induced arthritis (CIA), a mouse model for RA. " 03/01/2021 - "In the present study, we evaluated the efficacy of radiopharmaceuticals that target macrophage mannose receptors (99mTc-labeled mannosylated dextran or 99mTc(CO)3-DCM20) and hypoxia (copper(II) diacetyl-di(N4-methylthiosemicarbazone) or Cu-ATSM) for the early detection of RA in collagen-induced arthritis (CIA) mice models. "

Related Drugs and Biologics

1.	Mannose (D-Mannose)
2.	Azithromycin (Zithromax)
3.	Ligands
4.	Proteins (Proteins, Gene)
5.	Cytokines
6.	Interleukin-10 (Interleukin 10)
7.	Scavenger Receptors (Scavenger Receptor)
8.	Dextrans (Dextran)
9.	Radiopharmaceuticals
10.	dectin 1

Related Therapies and Procedures

1.	Intranasal Administration
2.	Therapeutics
3.	Immunotherapy
4.	Chinese Traditional Medicine (Traditional Chinese Medicine)
5.	Enzyme Therapy