Anticoagulation Reversal

Treatment strategies used to manage bleeding events that occur during the use of ANTICOAGULANTS.

Also Known As:

Anticoagulant Reversals; Anticoagulation Reversals; Reversal, Anticoagulant; Reversal, Anticoagulation; Reversals, Anticoagulant; Reversals, Anticoagulation; Anticoagulant Reversal; Reversal of Anticoagulation

Networked: 244 relevant articles (7 outcomes, 13 trials/studies)

Relationship Network

Therapy Context: Research Results

Therapeutics: 1158551
- Hemostatic Techniques: 124
  - Anticoagulation Reversal: 244

Experts

1.	Milling, Truman J: 6 articles (06/2022 - 03/2018)
2.	Crowther, Mark: 4 articles (06/2022 - 09/2011)
3.	Goldstein, Joshua N: 4 articles (09/2019 - 01/2006)
4.	Levy, Jerrold H: 4 articles (05/2017 - 11/2008)
5.	Lu, Genmin: 3 articles (06/2022 - 01/2020)
6.	Siegal, Deborah M: 3 articles (01/2021 - 04/2015)
7.	Gerner, Stefan T: 3 articles (11/2020 - 02/2015)
8.	Huttner, Hagen B: 3 articles (11/2020 - 02/2015)
9.	Pollack, Charles V: 3 articles (10/2020 - 05/2017)
10.	Sarode, Ravi: 3 articles (10/2020 - 09/2014)

Related Diseases

1.	Hemorrhage 04/10/2012 - "The rapid reversal of anticoagulation may be effective in preventing excess bleeding." 01/01/2021 - "Anticoagulant reversal trials offer prospectively gathered data after major bleeding with well-documented safety events and restarting behavior. " 05/15/2016 - "Preliminary Phase III trial results demonstrated a median maximum reversal of 100%, a median time to bleeding cessation of 11.4 hours, and normal intraoperative hemostasis in 92% of patients requiring anticoagulation reversal before an urgent procedure. " 09/01/2014 - "Most recommendations are based on expert opinions only as randomized trials using agents for reversal of anticoagulation in case of life-threatening bleeding or of major urgent surgery are not available. " 08/01/2023 - "Compared to those without an assay, patients with preoperative DOAC assays had odds 1.44× higher for major bleeding, 2.98× higher for in-hospital mortality and 16.3× higher for receiving anticoagulant reversal. "
2.	Cerebral Hemorrhage 10/01/2019 - "Anticoagulation reversal, intensive blood pressure lowering, neurosurgery, and access to critical care might all be beneficial in acute intracerebral hemorrhage (ICH). " 01/01/2023 - "The aim is to determine the effectiveness of a goal-directed care bundle of intensive blood pressure (BP) lowering, glycemic control, antipyrexia, and anticoagulation reversal treatment versus usual standard of care, in patients with acute intracerebral hemorrhage (ICH). " 01/01/2020 - "Blood Pressure and Anticoagulation Reversal Management during Off-Hours in Oral Anticoagulation-Associated Intracerebral Hemorrhage." 06/01/2019 - "Anticoagulation reversal in the setting of acute intracerebral hemorrhage is an evolving field. " 12/01/2015 - "Spontaneous intracerebral hemorrhage is a true neurological emergency, and its management is made more complicated when patients are anticoagulated, as reversal of anticoagulation must be initiated simultaneously with diagnosis, treatment, and disposition. "
3.	Fever (Fevers) 01/01/2022 - "The third INTEnsive care bundle with blood pressure Reduction in Acute Cerebral Haemorrhage Trial is an ongoing international, multicentre, stepped wedge, cluster-randomized trial to determine the effectiveness of a goal-directed care bundle (early intensive blood pressure [BP] lowering, glycaemic control, treatment of pyrexia, and reversal of anticoagulation), as compared to standard of care, on patient-centred outcomes after acute intracerebral haemorrhage (ICH). " 12/20/2021 - "Early intensive blood pressure (BP) lowering remains the most promising treatment for acute intracerebral hemorrhage (ICH), despite discordant results between clinical trials and potential variation in the treatment effects by approach to control BP. As the third in a series of clinical trials on this topic, the INTEnsive care bundle with blood pressure Reduction in Acute Cerebral hemorrhage Trial (INTERACT3) aims to determine the effectiveness of a goal-directed care bundle protocol of early physiological control (intensive BP lowering, glycemic control, and pyrexia treatment) and reversal of anticoagulation, in acute ICH. " 12/20/2021 - "After a control phase, each hospital implements the intervention (intensive BP lowering, target systolic < 140 mmHg; glucose control, target 6.1-7.8 mmol/L and 7.8-10.0 mmol/L in those without and with diabetes mellitus, respectively; anti-pyrexia treatment to target body temperature ≤ 37.5 °C; and reversal of anticoagulation, target international normalized ratio < 1.5 within 1 h). "
4.	Stroke (Strokes) 05/01/2022 - "Implementation of a stroke response team increased the knowledge of the care team, improved the timeliness of blood pressure control, and decreased the time for emergency department arrival to a critical care bed, and to anticoagulation reversal agent administration." 01/01/2021 - "Conclusions: Anticoagulant reversal in patients presenting with a stroke remains a major issue, and algorithms based on a step-by-step approach may be useful for clinical practise. " 11/01/2011 - "However, reversal of anticoagulation and antiplatelet therapy was required due to a spontaneous bleed from an intercostal artery, and this led to in-stent thrombosis and major stroke. " 12/01/2006 - "The absence of focal neurologic deficits, combined with the high stroke risk with anticoagulation reversal, prompted a nonoperative approach. " 07/01/2005 - "Two ED anticoagulated patients died, one required a second surgery for bleeding complications, and another suffered a stroke after reversal of anticoagulation. "
5.	Thrombocytopenia (Thrombopenia) 02/01/2016 - "Sudden Development of Thrombocytopenia After Reversal of Anticoagulation for Surgery." 04/01/1997 - "The protamine variant +18RGD was less toxic, induced less thrombocytopenia, and was more effective in anticoagulation reversal than was standard protamine sulfate. " 03/01/2021 - "Specific problems, including management of heparin-induced thrombocytopenia, anticoagulant reversal, novel oral anticoagulants, artificial heart valves, and noncardiac surgeries are covered in detail." 04/01/2007 - "Use of continuous venovenous hemofiltration for reversal of anticoagulation with lepirudin post-cardiopulmonary bypass in a patient with heparin-induced thrombocytopenia after heart transplantation." 07/01/2018 - "Fostamatinib (Tavalisse) for thrombocytopenia in adults with chronic immune thrombocytopenia; coagulation factor Xa (recombinant), inactivated-zhzo (Andexxa) for the reversal of anticoagulation; epoetin alfa-epbx (Retacrit), a biosimilar for the treatment of anemia."

Related Drugs and Biologics

1.	Protamines (Protamine Sulfate)
2.	Abciximab (ReoPro)
3.	Rivaroxaban
4.	Heparin (Liquaemin)
5.	Warfarin (Coumadin)
6.	Prothrombin (Factor II)
7.	Blood Coagulation Factors (Coagulation Factor)
8.	anti-inhibitor coagulant complex
9.	Anticoagulants
10.	Vitamin K

Related Therapies and Procedures

1.	Critical Care (Surgical Intensive Care)
2.	Patient Care Bundles
3.	Glycemic Control
4.	Percutaneous Coronary Intervention
5.	Therapeutics