Rhamnogalacturonans

Types of polysaccharides that are components of the plant cell wall pectin matrix. Rhamnogalacturonan I is characterized by a backbone of the repeating disaccharide (4)-alpha-D-galacturonic acid-(1,2)-alpha-L-rhamnose-(1,-) with many of the rhamnose residues substituted at C-4 with side chains of various neutral sugars linked together in various ways. Rhamnogalacturonan II type is complex, highly branched polysaccharide where the backbone consists exclusively of D-galacturonic acid units.

Networked: 3 relevant articles (0 outcomes, 0 trials/studies)

Bio-Agent Context: Research Results

Experts

1.	Carpita, Nicholas C: 1 article (05/2019)
2.	Fabi, João Paulo: 1 article (05/2019)
3.	Harazono, Yosuke: 1 article (05/2019)
4.	Hogan, Victor A: 1 article (05/2019)
5.	Raz, Avraham: 1 article (05/2019)
6.	Shiga, Tânia Misuzu: 1 article (05/2019)
7.	do Prado, Samira Bernardino Ramos: 1 article (05/2019)

Related Diseases

1.	Neoplasms (Cancer) 05/01/2019 - "MCP30/10 (between 30 and 10 kDa) had more esterified homogalacturonans (HG) and fewer rhamnogalacturonans (RG-I) than MCP and MCP30 (higher than 30 kDa), while MCP10/3 (between 10 and 3 kDa) showed higher amounts of type I arabinogalactans (AGI) and lower amounts of RG-I. MCP3 (smaller than 3 kDa) presented less esterified HG and the lowest amount of AGI and RG-I. Our data indicate that the enrichment of de-esterified HG oligomers and the AGI and RG-I depletions in MCP3, or the increase of AGI and loss of RGI in MCP30/10, enhance the anticancer behaviors by inhibiting migration, aggregation, and proliferation of cancer cells." 01/01/1994 - "Rhamnogalacturonan-mediated enhancement of cytotoxicity of fresh CD56+ NK cells was also observed with four of five NK-insensitive tumor cells as targets, indicating that the effector-cell/tumor-cell bridging activity of rhamnogalacturonans renders NK-insensitive targets susceptible to NK-mediated lysis. "
2.	Wounds and Injuries (Trauma) 08/01/1985 - "We have tested this hypothesis by infiltration of radioactive pectic fragments (rhamnogalacturonans and homogalacturonans of degrec of polymerisation down to 6) into wounds on tomato leaves. "