Chemotherapy-Related Cognitive Impairment

The diminished or impaired mental and/or intellectual function associated with the chemical treatment of cancer.

Also Known As:

Chemo Fog; Chemotherapy Induced Cognitive Dysfunction; Chemotherapy Induced Cognitive Impairment; Chemotherapy Induced Cognitive Impairments; Chemotherapy Related Cognitive Dysfunction; Chemotherapy Related Cognitive Impairment; Chemotherapy-Related Cognitive Dysfunctions; Chemotherapy-Related Cognitive Impairments; Cognitive Dysfunction, Chemotherapy-Induced; Cognitive Dysfunction, Chemotherapy-Related; Cognitive Impairment, Chemotherapy-Induced; Cognitive Impairment, Chemotherapy-Related; Cognitive Impairments, Chemotherapy-Induced; Cognitive Impairments, Chemotherapy-Related; Chemo-Fog; Chemobrain; Chemotherapy-Induced Cognitive Dysfunction; Chemotherapy-Induced Cognitive Impairment; Chemotherapy-Induced Cognitive Impairments; Chemotherapy-Related Cognitive Dysfunction

Networked: 287 relevant articles (17 outcomes, 51 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Chemotherapy-Related Cognitive Impairment
2.	Cognitive Dysfunction
3.	Breast Neoplasms (Breast Cancer)
4.	Neoplasms (Cancer)
5.	Neuroinflammatory Diseases

Experts

1.	Butterfield, D Allan: 12 articles (07/2018 - 11/2005)
2.	Sultana, Rukhsana: 8 articles (07/2018 - 11/2005)
3.	Heijnen, Cobi J: 7 articles (01/2022 - 01/2016)
4.	Kavelaars, Annemieke: 7 articles (01/2022 - 01/2016)
5.	St Clair, Daret K: 7 articles (01/2017 - 11/2005)
6.	Azab, Samar S: 6 articles (01/2022 - 07/2018)
7.	Vore, Mary: 6 articles (01/2015 - 11/2005)
8.	Cheng, Huaidong: 5 articles (01/2022 - 01/2016)
9.	Zhang, Zhang-Jin: 5 articles (01/2020 - 03/2015)
10.	Raffa, R B: 5 articles (08/2013 - 04/2006)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Chemotherapy-Related Cognitive Impairment:

1.	Doxorubicin (Adriamycin)FDA LinkGeneric 01/01/2021 - "Proposed mechanisms of the protective effects of bone marrow stem cells (BMSCs) and their exosomes (BMSCs-Exo) in doxorubicin (DOX)-induced chemobrain. " 01/01/2023 - "However, the effects of Mel and Met on doxorubicin (DOX)-induced chemobrain remain in need of elucidation. " 01/01/2021 - "Doxorubicin (DOX), a widely used chemotherapeutic agent, can cause neurodegeneration in the brain, which leads to a condition known as chemobrain. " 01/01/2021 - "One frequently reported side effect of chemotherapeutic agents like doxorubicin (Doxo) is impaired cognitive function, commonly known as "chemotherapy-induced cognitive impairment (CICI)", which may mimic accelerated brain aging. " 01/01/2020 - "Chemobrain in rats: Behavioral, morphological, oxidative and inflammatory effects of doxorubicin administration."
2.	Cholinergic Agents (Cholinergics)IBA 06/20/2023 - "While DOX damages the cholinergic system, few studies have focused on the protective effects of cholinergic function on chemobrain. " 10/29/2022 - "Levetiracetam Ameliorates Doxorubicin-Induced Chemobrain by Enhancing Cholinergic Transmission and Reducing Neuroinflammation Using an Experimental Rat Model and Molecular Docking Study."
3.	CytokinesIBA 01/01/2023 - "Various studies were conducted to evaluate the role of cytokines in chemotherapy-related cognitive impairment (CRCI). " 01/01/2022 - "Several mechanisms have been proposed to cause chemobrain but increase of proinflammatory cytokines with oxidative stress seem more relevant, not excluding the action on neurotransmission and cellular death or impaired hippocampal neurogenesis. " 01/01/2021 - "DOX-induced chemobrain is presumed to be due to cytokine-induced inflammatory, oxidative, and apoptotic responses damaging the brain. " 01/01/2020 - "The present results indicated that changes in cytokine levels may occur in BC patients with chemotherapy-related cognitive impairment (CRCI). " 03/01/2019 - "These results indicate that chemobrain is associated with cytokine dysregulation and disrupted neuroplasticity of the brain."
4.	ResveratrolIBA 01/01/2018 - "These results demonstrate the efficacy of resveratrol in preventing chemobrain and its association with cytokine modulation and neuroprotection." 01/01/2018 - "The purpose of this study was to examine whether resveratrol, a natural polyphenol that has nootropic effects, could prevent chemobrain and its underlying mechanisms. " 01/01/2018 - "Resveratrol, a natural polyphenol, prevents chemotherapy-induced cognitive impairment: Involvement of cytokine modulation and neuroprotection." 11/15/2021 - "For the first time, this review focuses on the published effects of astaxanthin, omega-3 fatty acids, ginsenoside, cotinine, resveratrol, polydatin, catechin, rutin, naringin, curcumin, dehydrozingerone, berberine, C-phycocyanin, the higher fungi Cordyceps militaris, thyme (Thymus vulgaris) and polyherbal formulation Mulmina™ in mitigating cognitive impairments in preclinical models of study, and also addresses their potential neuro-therapeutic mechanisms and applications in preventing/ameliorating chemobrain."
5.	BerberineIBA 01/01/2022 - "A Review on the Neuroprotective Effect of Berberine against Chemotherapy- induced Cognitive Impairment." 03/15/2021 - "Berberine ameliorates doxorubicin-induced cognitive impairment (chemobrain) in rats." 11/15/2021 - "For the first time, this review focuses on the published effects of astaxanthin, omega-3 fatty acids, ginsenoside, cotinine, resveratrol, polydatin, catechin, rutin, naringin, curcumin, dehydrozingerone, berberine, C-phycocyanin, the higher fungi Cordyceps militaris, thyme (Thymus vulgaris) and polyherbal formulation Mulmina™ in mitigating cognitive impairments in preclinical models of study, and also addresses their potential neuro-therapeutic mechanisms and applications in preventing/ameliorating chemobrain."
6.	Metformin (Glucophage)FDA LinkGeneric 01/01/2022 - "This review discusses recent clinical/preclinical studies that addressed some mechanisms of chemobrain and evaluates the effect of metformin in rescuing chemobrain and its potential mechanisms of action." 01/01/2022 - "Recently, several studies have examined the effect of metformin in rescuing chemobrain. " 01/01/2022 - "Research advances on how metformin improves memory impairment in "chemobrain"." 01/01/2022 - "Metformin, used as a first-line treatment for type 2 diabetes mellitus, is reported to reduce the effects of chemobrain. " 01/01/2023 - "Melatonin and metformin counteract cognitive dysfunction equally in male rats with doxorubicin-induced chemobrain."
7.	CotinineIBA 11/01/2016 - "Most cancer patients treated with systemic adjuvant chemotherapy endure long-lasting side effects including decrease in concentration, forgetfulness and slower thinking, which are globally termed "chemobrain." Cotinine, the main derivative of nicotine, improved visual and spatial working memory and decreased depressive-like behavior in an animal model of chemotherapy-induced cognitive impairment. " 11/15/2021 - "For the first time, this review focuses on the published effects of astaxanthin, omega-3 fatty acids, ginsenoside, cotinine, resveratrol, polydatin, catechin, rutin, naringin, curcumin, dehydrozingerone, berberine, C-phycocyanin, the higher fungi Cordyceps militaris, thyme (Thymus vulgaris) and polyherbal formulation Mulmina™ in mitigating cognitive impairments in preclinical models of study, and also addresses their potential neuro-therapeutic mechanisms and applications in preventing/ameliorating chemobrain."
8.	polydatinIBA 06/01/2020 - "Polydatin ameliorates chemotherapy-induced cognitive impairment (chemobrain) by inhibiting oxidative stress, inflammatory response, and apoptosis in rats." 06/01/2020 - "Most breast cancer survivors receiving chemotherapy have severe cognitive impairment, often referred to as "chemobrain." Polydatin (PLD) is known to have many biological activities. " 11/15/2021 - "For the first time, this review focuses on the published effects of astaxanthin, omega-3 fatty acids, ginsenoside, cotinine, resveratrol, polydatin, catechin, rutin, naringin, curcumin, dehydrozingerone, berberine, C-phycocyanin, the higher fungi Cordyceps militaris, thyme (Thymus vulgaris) and polyherbal formulation Mulmina™ in mitigating cognitive impairments in preclinical models of study, and also addresses their potential neuro-therapeutic mechanisms and applications in preventing/ameliorating chemobrain."
9.	astaxanthine (astaxanthin)IBA 07/01/2018 - "Astaxanthin Ameliorates Doxorubicin-Induced Cognitive Impairment (Chemobrain) in Experimental Rat Model: Impact on Oxidative, Inflammatory, and Apoptotic Machineries." 11/15/2021 - "For the first time, this review focuses on the published effects of astaxanthin, omega-3 fatty acids, ginsenoside, cotinine, resveratrol, polydatin, catechin, rutin, naringin, curcumin, dehydrozingerone, berberine, C-phycocyanin, the higher fungi Cordyceps militaris, thyme (Thymus vulgaris) and polyherbal formulation Mulmina™ in mitigating cognitive impairments in preclinical models of study, and also addresses their potential neuro-therapeutic mechanisms and applications in preventing/ameliorating chemobrain."
10.	Histone Deacetylase InhibitorsIBA 12/01/2017 - "In the present study, sodium valproate, a well-known HDAC inhibitor, was explored for its neuroprotective potential against chemobrain development. "

Therapies and Procedures

1.	Drug Therapy (Chemotherapy) 01/01/2019 - "Ironically, the increasing efficacy of chemotherapy leaves growing number of patients alive with chemobrain. " 05/01/2010 - "Although women reported losing memory and concentration, "chemobrain" effect was not demonstrated as cognitive tests improved after 6 months, probably because of "learning effect." Women who had undergone chemotherapy gained weight and fat disposition was typically android. " 08/22/2023 - "Inclusion criteria were qualitative studies with a focus on children (0-18 years) during and/or following chemotherapy treatment and explored children's experiences of chemobrain. " 01/01/2022 - "This review of qualitative studies will focus on the pediatric population (0 to 18 years of age) during and/or following chemotherapy treatment to identify their experiences with chemobrain. " 01/01/2018 - "However, studies using neuropsychological metrics have also reported group differences in cognitive function and memory before or without chemotherapy, suggesting that complex factors obscure the true etiology of chemotherapy-induced cognitive dysfunction (CICD) in humans. "
2.	Adjuvant Chemotherapy 01/01/2005 - "However, mild cognitive impairment (MCI), also known as ''chemofog'' or ''chemobrain'' following adjuvant chemotherapy for breast cancer has been reported since the late 1980s. " 06/01/2023 - "Adjuvant chemotherapy for breast cancer is undeniably effective in increasing survival rates but many breast cancer survivors (BCS) exhibit side effects including nausea, fatigue, stress, and neurocognitive deficits, known as "chemobrain." This pilot study explored how neurotherapy, or EEG biofeedback, a non-pharmacological approach, improved neurocognitive, behavioral, and neurophysiological deficits associated with BCS who underwent chemotherapy. " 11/01/2016 - "Most cancer patients treated with systemic adjuvant chemotherapy endure long-lasting side effects including decrease in concentration, forgetfulness and slower thinking, which are globally termed "chemobrain." Cotinine, the main derivative of nicotine, improved visual and spatial working memory and decreased depressive-like behavior in an animal model of chemotherapy-induced cognitive impairment. "
3.	Acupuncture Therapy 05/08/2018 - "Efficacy of Acupuncture Therapy for Chemotherapy-Related Cognitive Impairment in Breast Cancer Patients."
4.	Psychology Biofeedback (Biofeedback) 06/01/2023 - "Adjuvant chemotherapy for breast cancer is undeniably effective in increasing survival rates but many breast cancer survivors (BCS) exhibit side effects including nausea, fatigue, stress, and neurocognitive deficits, known as "chemobrain." This pilot study explored how neurotherapy, or EEG biofeedback, a non-pharmacological approach, improved neurocognitive, behavioral, and neurophysiological deficits associated with BCS who underwent chemotherapy. "
5.	Therapeutics 11/01/2007 - "Better designed future trials should lead to a better definition and understanding of chemobrain and to future therapies." 01/01/2021 - "Chemotherapy-induced cognitive impairments (CICI) can be observed not only during pharmacological treatment of the disease but also long after cessation of this therapy. " 11/21/2012 - "Treating chemobrain: rehabilitation therapies emerge." 11/01/2012 - "Complementary and integrative medicine modalities that may improve chemotherapy-related cognitive impairment include mind-body techniques and acupuncture, as well as nutrition and herbal therapies. " 11/01/2012 - "We review current knowledge regarding the etiology of chemotherapy-related cognitive impairment, risk factors, conventional therapy, coping strategies, and potential complementary and integrative medicine treatments. "