Colitis-Associated Neoplasms

Colonic neoplasms associated with chronic inflammation conditions such as ULCERATIVE COLITIS and CROHN DISEASE.

Also Known As:

Cancer, Colitis-Associated Colon; Cancer, Colitis-Associated Colorectal; Colitis Associated Cancer; Colitis Associated Colon Cancer; Colitis Associated Colorectal Cancer; Colitis Associated Neoplasms; Colitis-Associated Cancers; Colitis-Associated Colon Cancers; Colitis-Associated Colorectal Cancers; Colitis-Associated Neoplasm; Colon Cancer, Colitis-Associated; Colorectal Cancer, Colitis-Associated; Neoplasm, Colitis-Associated; Colitis-Associated Cancer; Colitis-Associated Colon Cancer; Colitis-Associated Colorectal Cancer

Networked: 714 relevant articles (46 outcomes, 103 trials/studies)

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Colitis
2.	Neoplasms (Cancer)
3.	Inflammation (Inflammations)
4.	Colorectal Neoplasms (Colorectal Cancer)
5.	Colonic Neoplasms (Colon Cancer)

Experts

1.	Sun, Yang: 12 articles (04/2022 - 12/2009)
2.	Neurath, Markus F: 10 articles (01/2020 - 09/2008)
3.	Li, Yuhua: 9 articles (04/2022 - 12/2009)
4.	Liu, Li: 8 articles (01/2021 - 12/2009)
5.	Mei, Qibing: 8 articles (02/2020 - 12/2009)
6.	Chartier, Lauren C: 7 articles (01/2022 - 01/2018)
7.	Howarth, Gordon S: 7 articles (01/2022 - 01/2018)
8.	Mashtoub, Suzanne: 7 articles (01/2022 - 01/2018)
9.	Chirino, Yolanda I: 7 articles (07/2021 - 07/2016)
10.	Terrazas, Luis I: 7 articles (07/2021 - 07/2016)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Colitis-Associated Neoplasms:

1.	AzoxymethaneIBA 01/01/2019 - "Here, we show that Casp11-/- mice are highly susceptible to the azoxymethane (AOM)-DSS model of colitis-associated cancer (CAC), compared to their wild type (WT) littermates. " 01/01/2019 - "Furthermore, Fam64a deficiency suppresses azoxymethane (AOM)/DSS-induced colitis-associated cancer (CAC) in mice. " 01/01/2017 - "The protective effect of anti-S100a9 antibody treatment was also observed in azoxymethane (AOM)/DSS-induced colitis-associated cancer (CAC) mouse model. " 05/01/2014 - "Colitis-associated cancer was induced by DSS and azoxymethane (AOM) treatment. " 05/01/2013 - "Colitis-associated cancer was induced by DSS and azoxymethane (AOM). "
2.	Dextran SulfateIBA 04/01/2019 - "Colitis-associated colon cancer was induced in mice with conditional deletion of neutrophils (LysMCre;Mcl1fl/fl) and wild-type littermates (LysMCre;Mcl1wt/wt, control mice) by administration of azoxythmethane and/or dextran sulfate sodium. " 10/01/2010 - "We report that A/J and B6 mice also show differential susceptibility to colitis-associated colorectal cancer (CA-CRC) induced by combined administration of AOM and dextran sulfate. " 01/01/2021 - "Colitis and colitis-associated colorectal cancer were induced by administration of dextran sulfate sodium and azoxymethane in mice. " 01/01/2021 - "To identify colitis-associated cancer promoting factors, we investigated gene expression changes caused by dextran sulfate sodium (DSS)-induced colitis in mice. " 02/01/2012 - "Dextran sulfate sodium (DSS) induces experimental colitis and promotes colitis-associated cancer in rodents. "
3.	Dextrans (Dextran)FDA Link 01/15/2020 - "Role of transient receptor potential vanilloid subtype 4 in the regulation of azoymethane/dextran sulphate sodium-induced colitis-associated cancer in mice." 03/30/2019 - "Strikingly, MTC-miR146b mimic oral administration protected miR-146b-deficient mice from dextran sodium sulphate [DSS] injury and the colitis-associated cancer process. " 02/01/2014 - "In this study, we found that TRAIL-R-deficient mice exhibited a higher incidence of colitis and colitis-associated cancer than that of wild-type (WT) mice, and TRAIL-R expression was down-regulated in WT mice that were fed dextran sulphate sodium. " 12/26/2018 - "Deletion of p38α in DCs, but not in T cells, led to increased Tr1 and protected mice from dextran sodium sulfate-induced acute colitis and chronic colitis-associated colorectal cancer. " 01/01/2018 - "Therefore, using a mouse model of colitis-associated colon cancer (CAC) induced by azoxymethane and dextran sodium sulfate, we observed the dynamic and differential kinetics of Treg cells in blood, spleen and mesenteric lymph nodes (MLNs) as CAC progresses, highlighting a significant reduction in Treg cells in blood and spleen during early CAC development, whereas increasing percentages of Treg cells were detected in late stages in MLNs. "
4.	InflammasomesIBA 11/23/2023 - "ZNF70 regulates IL-1β secretion of macrophages to promote the proliferation of HCT116 cells via activation of NLRP3 inflammasome and STAT3 pathway in colitis-associated colorectal cancer." 02/28/2019 - "Pretreatment with a Heat-Killed Probiotic Modulates the NLRP3 Inflammasome and Attenuates Colitis-Associated Colorectal Cancer in Mice." 01/01/2017 - "Small molecule GL-V9 protects against colitis-associated colorectal cancer by limiting NLRP3 inflammasome through autophagy." 06/01/2014 - "Small molecule-driven mitophagy-mediated NLRP3 inflammasome inhibition is responsible for the prevention of colitis-associated cancer." 01/01/2017 - "Multiple studies using a colitis-associated colon cancer model show that inflammasome components provide protection against the development of colon cancer. "
5.	sodium sulfate (sodium bisulfate)FDA LinkGeneric 01/01/2020 - "Twelve C57BL/6 J wild-type mice (WT) and 12 TLR2 knockout mice (TLR2-/-) were used to rapidly establish a colitis-associated cancer (CAC) model via the 1,2-dimethylhydrazine-dextran sodium sulfate (DMH-DSS) method and were divided into the normal WT control group (NC), TLR2 knockout control group (KC), normal wild-type tumor modeling group (NT), and TLR2 knockout tumor modeling group (KT), with 6 mice in each group. " 12/26/2018 - "Deletion of p38α in DCs, but not in T cells, led to increased Tr1 and protected mice from dextran sodium sulfate-induced acute colitis and chronic colitis-associated colorectal cancer. " 01/01/2018 - "Therefore, using a mouse model of colitis-associated colon cancer (CAC) induced by azoxymethane and dextran sodium sulfate, we observed the dynamic and differential kinetics of Treg cells in blood, spleen and mesenteric lymph nodes (MLNs) as CAC progresses, highlighting a significant reduction in Treg cells in blood and spleen during early CAC development, whereas increasing percentages of Treg cells were detected in late stages in MLNs. " 12/01/2021 - "This study was aimed to investigate the preventive effects and possible protective mechanism of PNS on a colitis-associated colorectal cancer (CAC) mouse model induced by azoxymethane (AOM)/dextran sodium sulfate (DSS). " 01/01/2019 - "In this study, we investigate the treatment effect of CMF in the azoxymethane (AOM) and dextran sodium sulfate (DSS) induced and high-fat diet augmented colitis-associated colorectal cancer in vivo, and explore its mechanism of action. "
6.	Proteins (Proteins, Gene)FDA Link 12/01/2023 - "Loss of polarity protein Par3 in the intestinal epithelium promotes colitis-associated colorectal cancer progression by damaging tight junction assembly." 01/01/2023 - "Protein stabilization of ITF2 by NF-κB prevents colitis-associated cancer development." 05/23/2021 - "Objective: To investigate the role and mechanism of ring finger protein 152 (RNF152) in the development of colitis-associated colon cancer (CAC). " 03/27/2020 - "Toll-Interacting Protein Regulates Immune Cell Infiltration and Promotes Colitis-Associated Cancer." 12/20/2019 - "The Role of Adaptor Protein CARD9 in Colitis-Associated Cancer."
7.	CateninsIBA 01/01/2015 - "Both agents reduced β-catenin expression on immunohistochemistry in a murine colitis-associated colon cancer model. " 03/21/2017 - "Adamts18 deficiency promotes colon carcinogenesis by enhancing β-catenin and p38MAPK/ERK1/2 signaling in the mouse model of AOM/DSS-induced colitis-associated colorectal cancer." 02/19/2016 - "We previously observed nuclear accumulation of Ser-552 phosphorylated β-catenin (pβ-Cat(Ser-552)) in intestinal epithelial cells (IEC) during colitis and colitis-associated cancer. " 02/19/2016 - "A Cytosolic Multiprotein Complex Containing p85α Is Required for β-Catenin Activation in Colitis and Colitis-associated Cancer." 01/01/2015 - "Morphology observation, HE staining, and p53 and β-catenin expression detection confirmed that drinking 3% DSS and 3% DSS combined with AOM intraperitoneal injection can successfully establish colitis and colitis associated colorectal cancer models. "
8.	Interleukin-27 (Interleukin 27)IBA 12/01/2023 - "Selectively increased intestinal TH17 cell responses in mice with Treg cell-specific IL-27 ablation led to exacerbated intestinal inflammation and colitis-associated cancer, but also helped protect against enteric bacterial infection. " 02/21/2023 - "Selectively increased intestinal Th17 responses in mice with Treg cell-specific IL-27 ablation led to exacerbated intestinal inflammation and colitis-associated cancer, but also helped protect against enteric bacterial infection. " 01/01/2017 - "Protective function of interleukin 27 in colitis-associated cancer via suppression of inflammatory cytokines in intestinal epithelial cells."
9.	Aspirin (Acetylsalicylic Acid)FDA LinkGeneric 01/01/2022 - "Aspirin activates resolution pathways to reprogram T cell and macrophage responses in colitis-associated colorectal cancer." 05/05/2023 - "Despite being shown to be effective for chemoprevention of colorectal cancer, aspirin has limitations including adverse effects and inability to block colitis-associated colon cancer (CAC). " 03/01/2023 - "However, explication of the detailed molecular mechanisms involved in the combined administration of aspirin and zinc-mediated protection against colitis-associated colorectal cancer deserves further investigation. "
10.	SodiumIBA 11/01/2020 - "We investigate the effects of Clostridium butyricum(CB) on gut microbiota and colitis associated colon cancer(CAC) in mice.6-8 weeks old C57BL/6 mice were randomly divided into control, azoxymethane (AOM) + dextran sodium sulphate (DSS) and AOM + DSS + CB groups. " 01/15/2020 - "Role of transient receptor potential vanilloid subtype 4 in the regulation of azoymethane/dextran sulphate sodium-induced colitis-associated cancer in mice." 03/30/2019 - "Strikingly, MTC-miR146b mimic oral administration protected miR-146b-deficient mice from dextran sodium sulphate [DSS] injury and the colitis-associated cancer process. " 02/01/2014 - "In this study, we found that TRAIL-R-deficient mice exhibited a higher incidence of colitis and colitis-associated cancer than that of wild-type (WT) mice, and TRAIL-R expression was down-regulated in WT mice that were fed dextran sulphate sodium. " 07/01/2020 - "Administration of Bifidobacterium bifidum CGMCC 15068 modulates gut microbiota and metabolome in azoxymethane (AOM)/dextran sulphate sodium (DSS)-induced colitis-associated colon cancer (CAC) in mice."

Therapies and Procedures

1.	Therapeutics 01/01/2016 - "Targeting this mechanism may help to improve the therapy of UC and prevent colitis-associated colorectal cancer." 01/01/2020 - "The findings also provide rationale and mechanistic insight for the study of IDO1 inhibitors as adjuvant therapy to radiation in patients with locally advanced sporadic and colitis-associated colorectal cancer." 07/01/2015 - "In this study, we designed a novel redox nanoparticle (RNP(O)) that is an ideal oral therapeutics for colitis-associated colon cancer treatment. " 01/01/2012 - "Experimental data suggest that these agents can potentially be used in a chemopreventive fashion to inhibit the development of colitis-associated colorectal cancer (CRC); however, observational studies investigating a possible risk reduction of CRC by 5-ASA therapy have revealed conflicting results. " 08/02/2023 - "Beneficial effects of alpha-1 antitrypsin therapy in a mouse model of colitis-associated colon cancer."
2.	Immunotherapy 10/01/2020 - "Role of myeloid-derived suppressor cells in the promotion and immunotherapy of colitis-associated cancer." 03/30/2019 - "MTC-miR146b should be regarded as an effective candidate for oral delivery and could improve the efficacy of immunotherapies for ulcerative colitis and colitis-associated cancer." 11/01/2019 - "Therefore, MUC13 is a potential marker of poor prognosis in colorectal cancer, and inhibiting MUC13 may be useful in the treatment of colitis-associated cancer and sensitizing tumors to immunotherapy."
3.	Chemoprevention 01/01/2020 - "[Colitis-associated cancer in ulcerative colitis -pathological condition and chemoprevention]." 07/28/2017 - "Enumerating crypts with increased numbers of pβ-cateninS552 - positive cells can be utilized as a biomarker in colitis-associated cancer chemoprevention trials." 08/01/2022 - "Potential Chemoprevention of Paeoniflorin in Colitis-Associated Colorectal Cancer by Network Pharmacology, Molecular Docking, and In Vivo Experiment." 07/01/2014 - "The PI3K/Akt pathway in colitis associated colon cancer and its chemoprevention with celecoxib, a Cox-2 selective inhibitor." 05/05/2023 - "Despite being shown to be effective for chemoprevention of colorectal cancer, aspirin has limitations including adverse effects and inability to block colitis-associated colon cancer (CAC). "
4.	Oral Administration 07/01/2023 - "Oral administration of M13-loaded nanoliposomes is safe and effective to treat colitis-associated cancer in mice." 09/16/2023 - "Prevention of Colitis-Associated Cancer via Oral Administration of M13-Loaded Lipid Nanoparticles." 01/01/2018 - "In the AOM/DSS-induced colitis-associated cancer (CAC) model, the oral administration of STDME significantly decreased tumor incidence and inhibited the accumulation of myeloid-derived suppressor cells (MDSCs) while also inhibiting the downregulation of interferon-γ (IFN-γ) production during carcinogenesis. " 03/30/2019 - "Strikingly, MTC-miR146b mimic oral administration protected miR-146b-deficient mice from dextran sodium sulphate [DSS] injury and the colitis-associated cancer process. " 08/01/2015 - "Importantly, oral administration of COS prevented the development of aberrant crypt foci in a mouse model of colitis-associated colorectal cancer (CRC) via a mechanism involving AMPK activation-induced β-catenin suppression and caspase-3 activation. "
5.	Bone Marrow Transplantation (Transplantation, Bone Marrow) 01/01/2013 - "The aim of this study was to establish a model for combined bone marrow transplantation (BMT) and colitis-associated colorectal cancer (CAC) and to define the contribution of BM-derived cells during the inflammation associated with carcinogenesis. "