B-Cell Lymphoma 3 Protein

A member of the I kappa B family, B-cell lymphoma 3-encoded (bcl-3) protein is involved in the regulation of TRANSCRIPTIONAL ACTIVATION of NF-KAPPA B target genes.

Also Known As:

B Cell Lymphoma 3 Protein; BCL 3 Protein; Protein bcl-3, Proto-Oncogene; Protein c bcl 3; Protein, BCL-3; Protein, BCL3; Proteins c-bcl-3, Proto-Oncogene; Proto Oncogene Protein bcl 3; Proto Oncogene Proteins c bcl 3; bcl-3, Proto-Oncogene Protein; c-bcl-3, Protein; c-bcl-3, Proto-Oncogene Proteins; BCL-3 Protein; BCL3 Protein; Protein c-bcl-3; Proto-Oncogene Protein bcl-3; Proto-Oncogene Proteins c-bcl-3; c-bcl-3 Protein

Networked: 9 relevant articles (0 outcomes, 1 trials/studies)

Bio-Agent Context: Research Results

Amino Acids, Peptides, and Proteins: 1
- Proteins: 484843
  - Transcription Factors: 38804
    - B-Cell Lymphoma 3 Protein: 9
      - human BCL3 protein
      - mouse Bcl3 protein
  - Neoplasm Proteins: 2
    - Oncogene Proteins: 7793
      - Proto-Oncogene Proteins: 7
        B-Cell Lymphoma 3 Protein: 9
        human BCL3 protein
        mouse Bcl3 protein

Experts

1.	Clarkson, Richard W E: 1 article (10/2020)
2.	Conlan, R Steven: 1 article (10/2020)
3.	Davies, Julia: 1 article (10/2020)
4.	Ridley, Anne J: 1 article (10/2020)
5.	Turnham, Daniel J: 1 article (10/2020)
6.	Varnava, Athina: 1 article (10/2020)
7.	Yang, William W: 1 article (10/2020)
8.	Bergeron, Jean: 1 article (02/2018)
9.	Couture, Patrick: 1 article (02/2018)
10.	Drouin-Chartier, Jean-Philippe: 1 article (02/2018)

Related Diseases

1.	Neoplasms (Cancer) 10/15/2008 - "Immunohistochemistry in cases with suitable material revealed that tumor cells of the two cHL with IGH/BCL2 fusion and the cHL with IGH/BCL3 fusion expressed the BCL2 and BCL3 protein, respectively. " 04/01/2016 - "In the present study, the expression levels of BCL-3 protein and mRNA in 90 pairs of HCC and matched non-tumor tissues were analyzed using immunohistochemistry and reverse transcription‑quantitative polymerase chain reaction (RT‑qPCR). " 04/01/2016 - "We found that the expression levels of BCL-3 protein and mRNA in HCC tissues were significantly higher than those in the matched tumor-adjacent tissues. " 08/01/2003 - "Analysis of the composition of NF-kappaB complexes in the tumors revealed aberrant nuclear expression of multiple subunits, including c-Rel, p50, p52, RelA, RelB, and the Bcl-3 protein, as observed previously in human primary breast cancers. "
2.	B-Cell Lymphoma (Lymphoma, B Cell) 02/01/2018 - "However, LA with DSA significantly upregulated the whole blood expression of early growth response protein (EGR)1 (1.94-fold, P = .02), EGR3 (1.56-fold, P = .0008) and B-cell lymphoma 3-encoded protein (BCL3; 1.25-fold, P = .03). " 01/01/2018 - "We also found that incubation with Cripto protected MSCs from apoptosis caused by hypoxia or H2O2 exposure, and the level of caspase-3 decreased by the Cripto-induced expression of B-cell lymphoma 3-encoded protein (BCL3). "
3.	B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia) 12/01/2004 - "The BCL-3 protein is another member of the IkappaB family and is overexpressed in a subset of human B-cell chronic lymphocytic leukemias because of a chromosomal translocation. "
4.	Genetic Translocation (Chromosomal Translocation) 12/01/2004 - "The BCL-3 protein is another member of the IkappaB family and is overexpressed in a subset of human B-cell chronic lymphocytic leukemias because of a chromosomal translocation. "
5.	Neoplasm Metastasis (Metastasis) 10/15/2020 - "Overexpression of Bcl-3 enhanced migration and increased metastatic tumour burden of breast cancer cells in vivo, whereas overexpression of a mutant Bcl-3 protein, which is unable to bind p50, suppressed cell migration and metastatic tumour burden suggesting that disruption of Bcl-3/NF-κB complexes is sufficient to inhibit metastasis. "

Related Drugs and Biologics

1.	Messenger RNA (mRNA)
2.	Caspase 3 (Caspase-3)
3.	NF-kappa B (NF-kB)
4.	Transcription Factors (Transcription Factor)
5.	Proteins (Proteins, Gene)
6.	IgA receptor (protein B)