BCL2 and BCL3 are recurrent translocation partners of the IGH locus.

Abstract	Chromosomal translocations affecting the immunoglobulin heavy chain (IGH) locus in chromosomal band 14q32 are the most frequent cytogenetic changes in B-cell lymphomas. We studied the presence of IGH translocations in a consecutively ascertained series of 94 classical Hodgkin lymphomas (cHL) by combined immunofluorescence for CD30 and interphase cytogenetics (FICTION technique). The Hodgkin and Reed-Sternberg cells of a total of 11 of 87 evaluable cases (13%) showed signal patterns indicative of IGH translocations. To identify the translocation partners, these cases were further studied with probes for the MYC, BCL2, BCL6, BCL3, REL/BCL11A, JAK2/PDCD1LG2 (alias PDL2) C14orf43, and C2TA loci. The IGH translocation partner could be identified in four cHL and involved BCL2 and BCL3 in two cases each. Immunohistochemistry in cases with suitable material revealed that tumor cells of the two cHL with IGH/BCL2 fusion and the cHL with IGH/BCL3 fusion expressed the BCL2 and BCL3 protein, respectively. These data indicate that BCL2 or BCL3 are recurrent translocation partners of the IGH locus in cHL; however, most of the translocation partners of IGH translocations in cHL remain to be identified.
Authors	Natalia Szymanowska, Wolfram Klapper, Stefan Gesk, Ralf Küppers, José I Martín-Subero, Reiner Siebert
Journal	Cancer genetics and cytogenetics (Cancer Genet Cytogenet) Vol. 186 Issue 2 Pg. 110-4 (Oct 15 2008) ISSN: 1873-4456 [Electronic] United States
PMID	18940474 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	B-Cell Lymphoma 3 Protein BCL3 protein, human Immunoglobulin Heavy Chains Proto-Oncogene Proteins Transcription Factors
Topics	Adolescent Adult Aged Aged, 80 and over B-Cell Lymphoma 3 Protein Child Female Gene Fusion Genes, bcl-2 Hodgkin Disease (genetics) Humans Immunoglobulin Heavy Chains (genetics) Male Middle Aged Proto-Oncogene Proteins (genetics) Transcription Factors (genetics) Translocation, Genetic

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