Nanogels

Three-dimensional biocompatible materials formed by cross-linking a hydrophilic polymeric component (e.g., HYDROGELS). They are typically spherical particles in a size range of 20-250 nm when used for drug delivery applications.

Also Known As:

Networked: 821 relevant articles (72 outcomes, 103 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Shi, Xiangyang: 20 articles (01/2022 - 09/2013)
2.	Shen, Mingwu: 13 articles (01/2022 - 11/2015)
3.	Wang, Xin: 13 articles (11/2021 - 02/2014)
4.	Tang, Rupei: 12 articles (11/2021 - 01/2017)
5.	Zhong, Zhiyuan: 11 articles (04/2019 - 05/2011)
6.	Chen, Wei: 10 articles (05/2022 - 10/2011)
7.	Akiyoshi, Kazunari: 10 articles (01/2022 - 03/2008)
8.	Calderón, Marcelo: 10 articles (01/2022 - 03/2016)
9.	Zhao, Xia: 9 articles (12/2021 - 10/2010)
10.	Cheng, Xu: 9 articles (11/2021 - 09/2017)

Related Diseases

1.	Neoplasms (Cancer) 07/01/2019 - "Interestingly, these show that the liver uptake of Hep nanogels is remarkably reduced and tumor accumulation significantly improved as compared to HA nanogels (intensity ratios of tumor-to-liver of 2.2 and 1.4 for the un-crosslinked and crosslinked Hep NGs versus 0.11 for the un-crosslinked and crosslinked HA ones). " 07/01/2018 - "In vivo antitumor experimentproved that LA modification could significantly enhance the tumor-targeting ability of nanogels and increase DOX concentration in tumor site, leading to better therapeutic efficacy. " 11/17/2023 - "The CFA/PRV@MM nanogels demonstrate superior therapeutic efficacy in a mouse breast model, resulting in effective tumor ablation and immune response with minimal side effects. " 01/01/2017 - "In vitro and in vivo results demonstrate that the nanogels could be efficiently internalized by 2D cells and 3D-MCs, improve drug concentration in solid tumors, and lead to higher therapeutic efficacy. " 03/01/2023 - "Based on the results of in vitro studies, DOX-loaded nanogels were found to be effective on cancer cells, while the neat ones were nondestructive in both lines. "
2.	Breast Neoplasms (Breast Cancer) 01/01/2022 - ""Attractive/adhesion force" dual-regulatory nanogels capable of CXCR4 antagonism and autophagy inhibition for the treatment of metastatic breast cancer." 01/01/2022 - "The result indicates that Cs-P123-FA nanogels with a higher decorated FA content perform a better targeting efficiency; therefore, they could have great potential application towards breast cancer treatment." 12/08/2021 - "In the in vivo investigation, the breast cancer tumour-bearing mice, the model animals for tumour treatment, were treated with an intratumoral injection of the PEG-CMC/HAP/GO nanocomposite hydrogel. " 06/25/2019 - "DTX and N9 co-loaded PVA nanogels exhibited a much higher antitumor efficiency in 4T1 mouse breast cancer models in vivo as compared to the free drug controls. " 01/01/2018 - "Systematic variations of near-IR labeled nanogels, comprising varying particle sizes (28-135 nm), PEG corona quantity (0-50 mol %), and PEG length (PEG Mn 1000, 2000, and 5000), were prepared and injected in mice that had been subcutaneously implanted with MDA-MB-231-luc-D3H2LN human mammary carcinoma. "
3.	Colonic Neoplasms (Colon Cancer) 04/28/2020 - "In vitro studies of the human colon cancer cell line (HCT-116) showed a synergistic effect of CUR and the degradable nanogels. " 01/09/2021 - "Overall, according to the data, the simultaneous delivery of the dual drugs through the fabricated nanogels could synergistically potentiate the antitumor effects on the colon cancer (CC)." 03/01/2016 - "When CD44-overexpressing HCT-116 colon cancer cells were treated with GzmB-encapsulated HA-EGCG nanogels in vitro, a significant cytotoxic effect was observed. " 04/28/2020 - "Here, we report on the use of a nanoformulation of CUR with cationic nanogels for colon cancer therapy. " 01/01/2021 - "Despite the different nature of these PSs, nanogels from gelator 1 provide, in both cases, an efficient intracellular transport into human colon adenocarcinoma cells (HT-29) and a notably improved PDT efficiency, as assessed by confocal laser scanning microscopy and flow cytometry. "
4.	Carcinoma (Carcinomatosis) 06/15/2017 - "In vitro study indicates that the nanogels are quickly taken up by KB cells (a human epithelial carcinoma cell line), exerting improved anticancer cytotoxicity, showing their potential for delivery of therapeutic agents beyond anticancer drugs." 09/01/2017 - "The DOX-loaded nanogels displayed pH-/thermo-dual responsivenesses in drug release, which can be effectively internalized into KB cells (a human epithelial carcinoma cell line) to exert good anticancer bioactivity. " 10/26/2010 - "The HPEI nanogels delivering pVSVMP have promising application in treating colon carcinoma." 07/01/2014 - "In vivo, PTX-loaded nanogels presented remarkably higher antitumor efficacy against human colon carcinoma cells HT-29 xenograft nude mice model after intravenous administration. " 07/18/2018 - "With outstanding long circulation time, high tumor accumulation, and sufficient drug release in a reduction environment, DOX-loaded PSBMA nanogels demonstrated the strongest tumor growth inhibition effect among all of the treatment groups in human hypopharyngeal carcinoma-bearing mouse models. "
5.	Neoplasm Metastasis (Metastasis) 08/25/2022 - "Additionally, histopathological analyses showed that the group treated with the MTX-loaded nanogels had less lung metastasis and glomerular damage caused by MTX. " 01/01/2015 - "Nanogels accumulated even more efficiently in metastases (29.9% and 30.4% ID/g at 24 and 48 h). " 12/01/2011 - "Our results indicate that Ad vectors modified by HPEI nanogels to form HPEI-Ad complexes enhanced transfection efficiency in CT26 cells that lacked CAR, targeted to the lung and demostrated a potential therapy for pulmonary metastasis." 01/01/2022 - "This nanocomposite hydrogel system improved tumor penetration and retention of drug in primary tumors as well as the drug deposition in lymph nodes, which significantly suppressed tumor growth and metastasis." 03/01/2023 - "Thus, the nanocomposite hydrogel, which is designed to exploit multiple known vulnerabilities of HNSCC, succeeds in suppressing both growth and metastasis of HNSCC."

Related Drugs and Biologics

1.	Doxorubicin (Adriamycin)
2.	Curcumin
3.	Chitosan
4.	Gelatin
5.	Peptides (Polypeptides)
6.	Polymers
7.	Proteins (Proteins, Gene)
8.	Cisplatin (Platino)
9.	Gold
10.	Paclitaxel (Taxol)

Related Therapies and Procedures

1.	Therapeutics
2.	Drug Therapy (Chemotherapy)
3.	Injections
4.	Precision Medicine
5.	Lasers (Laser)