Folic acid-modified biocompatible Pullulan/poly(acrylic acid) nanogels for targeted delivery to MCF-7 cancer cells.

Abstract

We prepared a novel nanogel consisting of poly(acrylic acid) (PAA) and pullulan (Pull) via a facile and green irradiation protocol. Synthesized nanogels were modified with bovine serum albumin (BSA) and folic acid (FA) and then loaded with doxorubicin (DOX) to obtain a delivery system with tumor-specific targeting ability and enhanced biocompatibility. In-vitro DOX release was investigated at different pH values, and it was found that DOX release was higher in acidic media, which is an advantage for the internalization of nanoparticles in acidic tumor environment. MTT assay and DAPI staining were performed to evaluate the effects of nanogels on L929 and MCF-7 cells. Based on the results of in vitro studies, DOX-loaded nanogels were found to be effective on cancer cells, while the neat ones were nondestructive in both lines. Overall, we envision that the biocompatible and tumor-specific nanogels could be a promising safe drug carrier system for cancer therapy.

• Authors: Mohammadreza Ghaffarlou, S Duygu Sütekin, Elif Karacaoğlu, Seçil Karahisar Turan, Özlem Gülüm İnci, Olgun Güven, Murat Barsbay
• Journal: European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V (Eur J Pharm Biopharm) Vol. 184 Pg. 189-201 (Mar 2023) ISSN: 1873-3441 [Electronic] Netherlands
• PMID: 36764499 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Elsevier B.V. All rights reserved.

Chemical References

• Nanogels
• carbopol 940
• pullulan
• Folic Acid
• Doxorubicin
• Drug Carriers

Topics

• Humans
• Nanogels
• MCF-7 Cells
• Folic Acid
• Doxorubicin
• Drug Carriers
• Nanoparticles
• Hydrogen-Ion Concentration
• Drug Delivery Systems
• Neoplasms