Tigecycline (Tygacil)

A tetracycline derivative that acts as a protein synthesis inhibitor. It is used as an antibacterial agent for the systemic treatment of complicated skin and intra-abdominal infections. It is also used for the treatment of community-acquired pneumonia.

Also Known As:

Tygacil; 9-(tert-Butylglycylamido)minocycline; GAR 936; GAR-936; TBG-MINO; GAR936; 2-Naphthacenecarboxamide, 4,7-bis(dimethylamino)-9-((2-((1,1-dimethylethyl)amino)acetyl)amino)-1,4,4a,5,5a,6,11,12a-octahydro-3,10,12,12a-tetrahydroxy-1,11-dioxo-, (4S,4aS,5aR,12aS)-

Networked: 1386 relevant articles (209 outcomes, 278 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Hsueh, Po-Ren: 18 articles (03/2022 - 01/2005)
2.	Nicolau, David P: 16 articles (09/2019 - 01/2005)
3.	Yu, Yunsong: 15 articles (09/2022 - 07/2010)
4.	Dartois, Nathalie: 14 articles (04/2014 - 01/2005)
5.	Dowzicky, Michael J: 14 articles (09/2013 - 07/2005)
6.	Jones, Ronald N: 14 articles (06/2013 - 02/2002)
7.	Bassetti, Matteo: 12 articles (09/2022 - 09/2010)
8.	Wang, Zhiqiang: 12 articles (02/2022 - 01/2020)
9.	Ko, Wen-Chien: 12 articles (05/2020 - 11/2007)
10.	Curcio, Daniel: 12 articles (06/2011 - 09/2005)

Related Diseases

1.	Infections 03/09/2018 - "We found once daily high dose tigecycline (HDT) was highly effective in treating serious systemic infections due to MDR Gram-positive/negative pathogens as well as C. " 03/01/2009 - "Despite the proven efficacy of tigecycline in the treatment of infections caused by these pathogens, questions remain as to the exposure-response relationship best associated with its efficacy. " 07/01/2005 - "A preliminary pharmacokinetic (PK)/pharmacodynamic analysis in experimental animal models of infection indicates that the efficacy of tigecycline is probably best predicted by the ratio of the area under the concentration-time curve to the minimum inhibitory concentration. " 01/01/2020 - "High dose tigecycline treatment is effective and safe for severe infections owing to its lower all-cause mortality, higher clinical cure, microbiological eradication and comparable adverse events. " 03/01/2010 - "Tigecycline appears to be effective for the successful treatment of PDR infections"
2.	Intraabdominal Infections 10/01/2008 - "This combined analysis demonstrates that tigecycline is safe and effective for the treatment of complicated intra-abdominal infections, and reflects the findings of the global population." 08/01/2006 - "Tigecycline has demonstrated promising results in initial in vitro and clinical studies for SSSIs and complicated intraabdominal infections; however, further clinical experience will clarify its role as a broad-spectrum agent." 07/01/2009 - "Tigecycline: a new treatment option for intra-abdominal infections." 07/01/2013 - "Efficacy of tigecycline for the treatment of complicated intra-abdominal infections in real-life clinical practice from five European observational studies." 12/01/2007 - "Tigecycline lacks activity in vitro against Pseudomonas and Proteus spp. In randomized clinical trials, tigecycline administered intravenously twice daily has demonstrated efficacy similar to comparators for a variety of complicated skin and skin structure and complicated intra-abdominal infections. "
3.	Pneumonia (Pneumonitis) 01/01/2017 - "Tigecycline monotherapy with either 50 or 100 mg would not be sufficient for most patients with bacteraemia, though the higher dose of 100 mg could be effective for patients with pneumonia with low bacterial load." 11/01/2011 - "The clinical resolution rate from such pneumonia might reflect the ultimate efficacy of tigecycline in treating MDRAB pneumonia and the overall efficacy might be overestimated." 01/01/2013 - "The objective of this study is to review the literature about the efficacy of tigecycline in community-acquired pneumonia. " 12/01/2011 - "The aim of this study was to evaluate the efficacy of tigecycline in multidrug-resistant (MDR) Acinetobacter baumannii pneumonia. " 12/01/2019 - "To comprehensively assess the safety and efficacy of tigecycline in pneumonia caused by Acinetobacter baumannii. "
4.	Sepsis (Septicemia) 06/01/2009 - "Tigecycline is the first member of the closely related glycylglycines and, due to its broad antimicrobial spectrum, it is considered useful in the treatment of sepsis. " 01/01/2018 - "The efficacy of tigecycline in the treatment of bloodstream infections (BSIs) remains controversial. " 05/01/2007 - "Concentration escalation studies demonstrate that tigecycline may need to approach concentrations higher than those currently achieved in the bloodstream to adequately treat CIRA bloodstream infections. " 01/01/2023 - "This strain, with a minimum inhibitory concentration (MIC) of 32 mg/L to tigecycline, was obtained from a sepsis patient. " 01/01/2023 - "Genome sequence of a tigecycline-resistant Acinetobacter seifertii recovered in human bloodstream infection in China."
5.	Healthcare-Associated Pneumonia 10/01/2005 - "Global clinical trials are underway to further assess the efficacy of tigecycline for community- and hospital- acquired pneumonia. " 01/01/2021 - "Tigecycline has been widely used to treat hospital-acquired pneumonia (HAP) off-label since it is effective against a wide range of multidrug-resistant bacteria. " 02/03/2010 - "The in vitro activity of tigecycline was evaluated against 819 baseline pathogens isolated from 383 patients enrolled in the phase 3 clinical trial investigating the efficacy of tigecycline in hospital acquired pneumonia (HAP). " 01/01/2022 - "Our study focused on the molecular and clinical efficacy of tigecycline for hospital-acquired pneumonia (HAP) in the ICU. " 02/01/2018 - "Determination of tigecycline in human plasma by LC-MS/MS and its application to population pharmacokinetics study in Chinese patients with hospital-acquired pneumonia."

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5.	Linezolid (Zyvox)
6.	Meropenem (Merrem)
7.	Daptomycin
8.	Imipenem
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10.	CL 331002 (glycylcycline)

Related Therapies and Procedures

1.	Therapeutics
2.	Liver Transplantation
3.	Salvage Therapy
4.	Catheters
5.	Intravenous Infusions