O-(Chloroacetylcarbamoyl)fumagillol (TNP 470)

01/01/2001 - "However, when TNP-470 was administered in the setting of microscopic disease 12 hr following tumor cell inoculation, treated mice had a significantly improved tumor-free survival at 12 weeks (P < 0.001), and overall survival at 45 weeks (P < 0.001), compared to control animals. "
01/01/1999 - "TNP-470 administration resulted in a significant reduction of the tumor growth rate and microvascular counts, and of the fraction of viable tumor cells, compared to controls. "
07/01/1998 - "Furthermore, the sustained effect of TNP-470 induced tumor dormancy and consequently improved the survival of the animals. "
01/01/1998 - "This indicates that excision of tumor created more favourable conditions for angiogenesis and that the dose of TNP-470 should be increased to be effective in such conditions."
12/01/1999 - "To further assess the relationship between the efficacy of TNP-470 treatment and tumor burden, TNP-470 was also administered s.c., 3 days/week, to mice with clinically evident small (<400 mm3; n = 15) and large (>400 mm3; n = 11) tumors. "

01/01/2012 - "Exploration of the molecular mechanisms by which TNP-470 inhibited growth and metastasis of CCA cell lines demonstrated expression of c-MYC, MMP2 and MMP9 to be decreased in TNP-470 treated cells. "
04/01/2007 - "TNP-470 prolonged survival and reduced liver metastases. "
12/01/2005 - "TNP-470 plus CTX showed synergetic effect on inhibiting metastasis on lung surface with a Q value of 1.21. "
07/01/2002 - "However, it is still unknown whether TNP-470 inhibits metastasis of TCC. "
06/01/2002 - "TNP-470 can alter the surface structure of GNM cell membrane, which suggests that TNP-470 may interrupt the metastasis of GNM cells."

02/01/2004 - "These results suggest that the clinical application of TNP-470 may be one of the possible treatments for the CDDP-resistant ovarian carcinomas."
09/01/2000 - "The in vitro proliferation of both bladder carcinoma cell lines was also inhibited by TNP-470. "
10/01/1997 - "One million PCI-43 cells, a human pancreas carcinoma cell line, were injected into the spleen of SCID beige mice, then TNP-470 at 30 mg/kg was administered subcutaneously every other day. "
12/01/1996 - "[Antitumor effect of TNP-470 against tongue carcinoma model by intratumor administration]."
04/15/1994 - "AGM-1470 was ineffective in significantly inhibiting the proliferation of Ea.hy926 cells, a hybrid cell line obtained by the fusion of human umbilical vein endothelial cells with a human carcinoma cell line, or cEnd.1 cells, a polyoma middle T oncogene-transformed endothelioma cell line derived from mouse embryo. "

02/01/2003 - "To study the effect of TNP-470 on cell growth, proliferation and apoptosis in human colon cancer xenografts in nude mice. "
02/01/2003 - "Effects of TNP-470 on proliferation and apoptosis in human colon cancer xenografts in nude mice."
10/01/2002 - "The MTT assay was used to evaluate the inhibitory effect of TNP-470 on human colon cancer cell line Lovo. "
01/01/2001 - "We have investigated the antimetastatic effect of TNP-470 against postoperative lung metastasis following the removal of human colon cancer xenotransplanted into nude rat. "
08/01/2000 - "The effect of TNP-470 was evaluated with in vitro and in vivo experiments using human colon cancer cell line, LM and the highly hepatic metastasis cell line, LM-H5. "

02/01/2004 - "It was found finally that TNP-470 given in the vicinity of the growing tumour can cause complete remission of the melanoma in hamsters treated in this way. "
01/01/2006 - "The atypical pattern of cell death in B16F10 melanoma cells treated with TNP-470."
09/01/2005 - "We observed short-term toxicity of TNP-470 in the B16F10 murine melanoma cell line in vitro and investigated the mechanism of action. "
05/01/2004 - "C57BL/6 mice carrying B16F10 melanomas were treated with anginex, TNP-470 or saline. "
09/15/1993 - "TNP-470 reduced the number of pulmonary metastatic foci of i.v. inoculated B16BL6 melanoma in a dose-dependent manner, and the number of metastatic foci was reduced to 10% of that in the control by treatment with TNP-470 at 60 mg/kg, 3 times/week. "