Fomepizole (Antizol)

10/01/2023 - "With the wider availability of fomepizole, the indications for ECTRs in EG poisoning are debated. "
01/01/2022 - "Our case provides additional evidence supporting the use of fomepizole for DEG poisoning. "
01/01/2022 - "Fomepizole is recommended for DEG poisoning, though supporting clinical evidence is limited. "
01/01/2020 - "Based on the long-standing clinical experience with fomepizole in France, we investigated its safety profile in patients treated for suspected toxic alcohol poisoning.Methods"
03/27/2012 - "There are few published cases worldwide of EG poisoning in children managed with fomepizole. "

09/01/2007 - "The purpose of this study was to describe the presentation, management and clinical course of toxic alcohol ingestions at a tertiary care referral center after the introduction of fomepizole to hospital formulary. "
01/01/2002 - "It is unknown whether fomepizole influenced his clinical course, but the rapid awakening observed suggests that it may have been usefuL Further experience is needed, however, to define the efficacy of this antidotal therapy in 1,4-butanediol intoxication."

12/01/2017 - "The co-administration of 100 mg 4-methylpyrazole/kg body weight had a similar effect on the adduct levels. "
01/01/2015 - "To inhibit ADH3-mediated retinol metabolism, 10 μg 4-methylpyrazole (4-MP)/g of body weight was administered to mice treated with CCl4 or subjected to BDL. "
09/01/1985 - "Time course experiments and dose-response experiments indicated that an increase in the microsomal oxidation of alcohols could be observed 24 hr after a single treatment with 200 mg/kg body weight of either pyrazole or 4-methylpyrazole, and after 2 or 3 days of treatment with 50 mg/kg of either of these compounds. "
01/01/1980 - "The injection of acetate (20 mmol/kg body weight) increased the liver PPi to 0.157 +/- 0.075 mumol/g in 15 min. The alcohol dehydrogenase inhibitor 4-methylpyrazole blocked the accumulation of acetate and the increase in PPi was prevented. "
07/01/1989 - "A 50-mg/ml solution of 4-methylpyrazole in propylene glycol was administered iv as follows: initial treatment, 20 mg/kg of body weight; at 17 hours after admission, 15 mg/kg; at 25 hours after admission, 5 mg/kg. By 24 hours after admission, all dogs had clinical and metabolic improvement. "

02/01/2010 - "Although the patient's outcome was death, his lactic acidosis was treated successfully with fomepizole and CVVH. "
02/10/2021 - "The lactic acidosis and his mental status completely normalised within 8 hours of renal replacement therapy initiation and fomepizole administration. "
01/01/2021 - "We describe a case of massive APAP overdose presenting with altered mental status and lactic acidosis, refractory to multiple treatments of IHD as well as CRRT and high-dose NAC along with fomepizole. "

12/01/2002 - "Fomepizole appeared safe and effective for a patient who had severe methanol poisoning presenting with visual impairment."
12/01/2002 - "To illustrate the safety and efficacy of fomepizole in a case of methanol poisoning with initial visual impairment. "
01/01/2001 - "Reversal of severe methanol-induced visual impairment: no evidence of retinal toxicity due to fomepizole."
12/01/2002 - "Fomepizole therapy for reversal of visual impairment after methanol poisoning: a case documented by visual evoked potentials investigation."
01/01/2001 - "We report a case of methanol poisoning exhibiting complete recovery from severe visual impairment following treatment with ethanol, fomepizole, and hemodialysis. "