Mivacurium (Mivacron)

An isoquinoline derivative that is used as a short-acting non-depolarizing agent.

Also Known As:

Mivacron; BW B1090U; BW-B 1090U; BW-B-1090U; BW-B1090U; Mivacurium Chloride; BW B 1090U; BWB 1090U; BWB1090U; Isoquinolinium, 2,2'-((1,8-dioxo-4-octene-1,8-diyl)bis(oxy-3,1-propanediyl))bis(1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-1-((3,4,5-trimethoxyphenyl)methyl))-, (1R,1'R)-

Networked: 158 relevant articles (6 outcomes, 15 trials/studies)

Relationship Network

Drug Context: Research Results

Heterocyclic Compounds: 198
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Isoquinolines: 34
      - Mivacurium: 158

Experts

1.	Ceppa, Franck: 3 articles (01/2021 - 01/2014)
2.	Schmitt, Hubert J: 3 articles (05/2009 - 02/2006)
3.	Courcelle, Sébastien: 2 articles (01/2021 - 09/2014)
4.	Delacour, Hervé: 2 articles (01/2021 - 09/2014)
5.	Lushchekina, Sofya: 2 articles (11/2016 - 01/2014)
6.	Masson, Patrick: 2 articles (11/2016 - 01/2014)
7.	Gätke, M R: 2 articles (07/2015 - 07/2015)
8.	Nielsen, C V: 2 articles (07/2015 - 07/2015)
9.	Thomsen, J L: 2 articles (07/2015 - 07/2015)
10.	Eskildsen, Katrine Zwicky: 2 articles (04/2015 - 03/2014)

Related Diseases

1.	Paralysis (Palsy) 10/01/2002 - "In contrast to previous studies with non-depolarizers in burned patients, normal mivacurium doses can produce paralysis, at least as rapidly as in controls, but with a possibility of a prolonged recovery from block. " 05/01/2005 - "The quantitative distinction between train-of-four "counts of 2" and posttetanic "counts of 2" evidenced by a stable paralysis/stable infusion rate method in anesthetized patients receiving mivacurium." 02/01/2005 - "The following case study describes causality and interventions for a patient with prolonged paralysis after receiving mivacurium." 02/01/2005 - "Prolonged paralysis has occurred 3 times in the past 2 years at this pediatric hospital after administration of mivacurium. " 02/01/2005 - "Prolonged paralysis related to mivacurium: a case study."
2.	Eye Diseases (Eye Disease) 05/01/1998 - "Forty patients without eye disease, undergoing elective nonophthalmic surgery, were studied in a double-blind, randomised, placebo-controlled study evaluating the efficacy of mivacurium pretreatment in attenuating the rise in intra-ocular pressure in response to suxamethonium administration, laryngoscopy and intubation. "
3.	Laryngismus (Laryngospasm) 05/01/1998 - "However, mivacurium decreased the incidence of swallowing, coughing, movement and laryngospasm (p < 0.05). " 02/01/1994 - "The authors speculate that the onset of intramuscular mivacurium is too slow to treat laryngospasm or to facilitate routine tracheal intubation in infants or children, despite administration of large doses." 02/01/1994 - "Mivacurium's rapid onset and short duration of action in children suggests that intramuscular administration might treat laryngospasm and facilitate tracheal intubation without producing prolonged paralysis. " 05/01/2000 - "However, an equally critical issue is whether there is a reliable replacement for succinylcholine for the treatment of laryngospasm or for rapid sequence induction in patients with "full stomachs." Succinylcholine produces more intense block in a shorter time at the laryngeal muscles, compared with the adductor pollicis, compared with vecuronium, rocuronium, mivacurium, and rapacuronium (30). "
4.	Erythema 12/01/2001 - "Arterial blood pressure declined and 13/30 patients manifested erythema following mivacurium administration. " 03/01/1995 - "One patient exhibited a 54% decrease in mean arterial pressure, generalized erythema and bronchospasm after mivacurium 0.2 mg kg-1. " 12/01/2001 - "Equi-lasting doses of rocuronium resulted in favourable intubating conditions more rapidly, improved hemodynamic stability, required less frequent administration of maintenance doses and were not associated with erythema, compared to mivacurium." 03/01/1995 - "Erythema developed in two, three and seven patients after atracurium, mivacurium 0.15 mg kg-1 and mivacurium 0.2 mg kg-1, respectively. " 03/01/1989 - "Facial erythema, decrease in blood pressure, and elevation of histamine level were all accentuated by increasing the dose of mivacurium and by more rapid injection of the drug. "
5.	Organophosphate Poisoning 02/01/2005 - "Administration of exogenous plasma cholinesterase also has been shown to be effective in antagonizing mivacurium-induced neuromuscular block, cocaine toxicity, and organophosphate poisoning."

Related Drugs and Biologics

1.	Cholinesterases (Cholinesterase)
2.	Succinylcholine (Suxamethonium Chloride)
3.	Rocuronium (Zemuron)
4.	Neostigmine (Neostigmine Bromide)
5.	Butyrylcholinesterase
6.	Edrophonium (Tensilon)
7.	Cocaine (Cocaine HCl)
8.	Vecuronium Bromide (Vecuronium)
9.	Cholinesterase Inhibitors (Anticholinesterases)
10.	Atracurium (Tracrium)

Related Therapies and Procedures

1.	Anesthesia
2.	Sutures (Suture)
3.	General Anesthesia
4.	Ambulatory Surgical Procedures (Outpatient Surgery)
5.	Laparoscopic Cholecystectomy