Rocuronium (Zemuron)

An androstanol non-depolarizing neuromuscular blocking agent. It has a mono-quaternary structure and is a weaker nicotinic antagonist than PANCURONIUM.

Also Known As:

Zemuron; 1-(17-(Acetoyl)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl)-1-(2-propenyl)pyrrolidinium; Esmeron; Esmerone; ORG 9426; ORG-9426; Pyrrolidinium, 1-((2beta,3alpha,5alpha,16beta,17beta)-17-(acetyloxy)-3-hydroxy-2-(4-morpholinyl)androstan-16-yl)-1-(2-propenyl)-, bromide; Rocuronium Bromide; ORG9426; Androstane-3,17-diol, 2-(4-morpholinyl)-16-(1-(2-propen-1-yl)-1-pyrrolidiniumyl)-, 17-acetate, (2beta,3alpha,5alpha,16beta,17beta)-

Networked: 813 relevant articles (70 outcomes, 132 trials/studies)

Relationship Network

Drug Context: Research Results

Polycyclic Compounds: 6
- Fused-Ring Compounds
  - Steroids: 70059
    - Androstanes: 11
      - Androstanols
        Rocuronium: 813

Experts

1.	Ebo, Didier G: 7 articles (01/2021 - 08/2007)
2.	Horiuchi, Tatsuo: 7 articles (01/2021 - 01/2014)
3.	Driessen, J J: 7 articles (07/2011 - 01/2000)
4.	Suzuki, Takahiro: 6 articles (01/2022 - 01/2012)
5.	Elst, Jessy: 6 articles (01/2021 - 01/2019)
6.	Sabato, Vito: 6 articles (01/2021 - 01/2019)
7.	Takazawa, Tomonori: 6 articles (01/2020 - 01/2014)
8.	de Boer, Hans D: 6 articles (07/2019 - 02/2008)
9.	Mertens, Christel: 5 articles (01/2021 - 01/2019)
10.	Van Gasse, Athina L: 5 articles (01/2021 - 01/2019)

Related Diseases

1.	Pain (Aches) 02/01/2013 - "Rocuronium was then administered and patients were asked to report their pain Compared to control group, all pretreatment drugs were effective in reducing pain on rocuronium injection. " 01/01/2020 - "The purpose of this study was to identify the difference of injection pain between original and generic rocuronium in pediatric population. " 12/01/2018 - "The purpose of this study was to identify the cause of vascular pain induced by the brand formulation and to develop a new rocuronium formulation, not causing vascular pain, using a vascular pain-evoked flexor reflex response model of anesthetized rats. " 02/12/2016 - "Most of the studies reported the primary outcome pain as assessed by verbal response from participants in an awake state but some trials reported withdrawal of the injected limb as a proxy for pain after induction of anaesthesia in response to rocuronium administration. " 02/12/2016 - "We included all randomized controlled trials (RCTs) that compared the use of any drug or a non-pharmacological method with control patients, or those receiving no treatment to reduce the severity of pain with rocuronium injection. "
2.	Anaphylaxis (Anaphylactic Shock) 01/15/2023 - "In other emergency situations such as anaphylactic shock caused by rocuronium or if intubation or ventilation is not possible, priority should be given to resuming ventilation maintaining hemodynamic stability, in accordance with the traditional guidelines. " 01/01/2022 - "Its unique mechanism of action, whereby it encapsulates and forms a one-to-one complex with rocuronium, has led to its anecdotal use as an adjunct in the treatment of anaphylactic and anaphylactoid reactions following rocuronium. " 12/07/2020 - "Recognition of rocuronium-induced anaphylaxis is often challenging, owing to its diverse clinical manifestations. " 01/01/2020 - "Ultimately, skin tests and basophil activation tests (BATs) performed after re-operation demonstrated rocuronium as the drug responsible for anaphylaxis. " 01/01/2020 - "This report presents a case of rocuronium-induced anaphylaxis in which early skin tests showed negative results for all the drugs tested. "
3.	Fasciculation (Fasciculations) 06/01/2014 - "The incidence and severity of visible muscle fasciculation was significantly less with increasing the amount of precurarizing dose of rocuronium (P < 0.001). " 12/01/2009 - "It is concluded that pretreatment with Rocuronium reduced the incidence of myalgias, fasciculations and produced rapid precurarization in one minute thereby saving time on busy operating lists. " 06/01/1998 - "Muscle fasciculations were observed in 19 of the 20 patients in the control group and in 3 of the 20 patients in the rocuronium group, the best of the pretreatments in that aspect. " 06/01/2014 - "Precurarization with 0.04 mg/kg rocuronium was the optimal dose considering the reduction in the incidence and severity of fasciculation and myalgia with acceptable onset time, and the safe and effective precurarization." 09/01/2012 - "Rocuronium did not deteriorate facemask ventilation, and it was improved after succinylcholine administration in association with airway dilation during pharyngeal fasciculation. "
4.	Myalgia 06/01/2014 - "Those of myalgia tend to decrease according to increasing the amount of precurarizing dose of rocuronium, but there was no significance (P = 0.072). " 06/01/2014 - "Precurarization with 0.04 mg/kg rocuronium was the optimal dose considering the reduction in the incidence and severity of fasciculation and myalgia with acceptable onset time, and the safe and effective precurarization." 10/01/2002 - "Based on the results of this study, pretreatment with lidocaine may provide better relief from myalgia than rocuronium at 48 hours after surgery." 03/01/2002 - "This study demonstrated that pretreatment of succinylcholine with rocuronium failed to decrease the incidence or the severity of postoperative myalgia. " 10/01/2005 - "Best prevention of myalgia was with nonsteroidal antiinflammatory drugs (number needed to treat, 2.5) and with rocuronium or lidocaine (number needed to treat, 3). "
5.	Paralysis (Palsy) 01/01/2023 - "Given the requirement for rapid and predictable paralysis for patient safety the efficacy of the two available formulations of rocuronium bromide was investigated in an animal model. " 06/01/2003 - "Significant reduction in rocuronium infusion requirements during the neohepatic phase was observed in the only patient who had poor graft function in the early postoperative stage, suggesting that the reduced infusion requirement to maintain a constant neuromuscular paralysis may be related to the functional state of the graft liver after reperfusion. " 08/01/2001 - "To evaluate the safety and efficacy of rocuronium for controlled intubation with paralysis (CIP) in the pediatric ED. " 12/01/2020 - "The aim of this study was to evaluate the hypothesis that the timing for safe tracheal intubation in elderly patients can be determined by acceleromyographically monitoring paralysis of the adductor pollicis muscle when high-dose rocuronium, given to block the respiratory muscles, is administered. " 01/01/2017 - "Impact of reversal strategies on the incidence of postoperative residual paralysis after rocuronium relaxation without neuromuscular monitoring: A partially randomised placebo controlled trial."

Related Drugs and Biologics

1.	Sugammadex
2.	Lidocaine (Xylocaine)
3.	Succinylcholine (Suxamethonium Chloride)
4.	Propofol (Diprivan)
5.	Vecuronium Bromide (Vecuronium)
6.	Fentanyl (Sublimaze)
7.	Remifentanil (Ultiva)
8.	Neostigmine (Neostigmine Bromide)
9.	Saline Solution
10.	Etomidate

Related Therapies and Procedures

1.	General Anesthesia
2.	Anesthesia
3.	Intravenous Injections
4.	Tourniquets
5.	Knee Replacement Arthroplasty (Total Knee Replacement)