Sodium Citrate

Sodium salts of citric acid that are used as buffers and food preservatives. They are used medically as anticoagulants in stored blood, and for urine alkalization in the prevention of KIDNEY STONES.

Also Known As:

Networked: 313 relevant articles (23 outcomes, 39 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Carr, Amelia J: 5 articles (01/2022 - 12/2016)
2.	Urwin, Charles S: 4 articles (01/2021 - 12/2016)
3.	Condo, Dominique: 3 articles (01/2021 - 10/2019)
4.	Snow, Rodney J: 3 articles (01/2021 - 10/2019)
5.	Wadley, Glenn D: 3 articles (01/2021 - 10/2019)
6.	Farah, Ibrahim O: 3 articles (01/2016 - 01/2007)
7.	Orellana, Liliana: 2 articles (01/2021 - 10/2019)
8.	Guo, Xing-Yu: 2 articles (01/2018 - 03/2016)
9.	Lu, Yun-Fei: 2 articles (01/2018 - 03/2016)
10.	Wang, Ting-An: 2 articles (01/2018 - 03/2016)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2018 - "In this study, we synthesized sodium citrate-AuNPs and CH-capped AuNPs of 3-10 nm, and analyzed their cytotoxicity in cervical (HeLa) and breast (MCF-7) cancer cells, and in peripheral blood mononuclear cells (PBMCs). " 10/31/2018 - "The functionalized DX-AuNPs demonstrated stronger inhibitory activity against cancer cells compared with sodium citrate-AuNPs and were nontoxic to normal cells. " 01/01/1969 - "[The effect of sodium citrate on the growth of transplantable tumors]." 07/24/2019 - "Tumor Microenvironment-Responsive Nanoshuttles with Sodium Citrate Modification for Hierarchical Targeting and Improved Tumor Theranostics." 01/01/2019 - "PA-capped nanoparticles displayed a 4-fold higher accumulation in the osteolytic lesions than sodium citrate-templated ones, and efficiently inhibited bone tumor growth and the tumor associated-osteolysis upon exposure to a near-infrared light. "
2.	Infections 01/01/2016 - "We analyzed the extent to which two methods for blood coagulate removal (defibrination or addition of sodium citrate) affected life table characteristics (i.e., fecundity, fertility, hatch rate, and adult survival) and vector competence (infection, dissemination, and transmission) of Aedes albopictus (Skuse) for dengue virus (DENV). " 01/01/1995 - "ORT with glucosolan and sodium citrate facilitates the restoration of pancreatic function in 65-70% of in patients with acute enteric infections of different etiology." 01/01/2022 - "Infection burden in mosquitoes was significantly reduced when blood was collected in sodium citrate and EDTA. " 10/16/2009 - "It seems that the use of 4% sodium citrate instead of 5000 IU/ml heparin does not decrease the frequency of infections. " 06/01/2009 - "Open-label randomized controlled trial of 2 catheter locks to examine the hypothesis that sodium citrate catheter locks will reduce catheter-related bacteremia and exit-site infection. "
3.	Sepsis (Septicemia) 09/27/2023 - "If at any point subsequently during their neonatal intensive care stay they develop signs and symptoms of possible sepsis requiring blood culture, an additional sodium citrate sample will be obtained. " 01/01/2012 - "Gentamicin 320 μg/mL in 4% sodium citrate used as a routine catheter lock in CVCs in patients on maintenance hemodialysis therapy markedly decreases the incidence of catheter-related bloodstream infection and is as effective as heparin 1,000 U/mL in preventing catheter clotting." 04/01/2011 - "To ascertain the safety and efficacy for prevention of catheter-related bloodstream infection and catheter loss from patency failure of a novel catheter lock solution with antimicrobial and antithrombotic activity containing 0.24 M (7.0%) sodium citrate, 0.15% methylene blue, 0.15% methylparaben, and 0.015% propylparaben (C-MB-P), compared with heparin. "
4.	Acidosis 02/01/1998 - "Administration of NaHCO3 or sodium citrate is important to prevent acidosis and nephrocalcinosis. " 11/01/1997 - "Acute ingestion of sodium citrate prior to exercise resulted in a reduction in post-exercise acidosis despite a blood lactate concentration that was similar to that observed after the ingestion of a placebo, but did not affect exercise performance under the conditions of this study." 07/01/1992 - "III. Study of gastric retention of a sodium citrate solution using an experimental model of metabolic acidosis in rats]." 08/01/1984 - "Sodium citrate corrected predialysis metabolic acidosis (plasma pH 7.41 compared to 7.35; serum bicarbonate, 21.1 compared to 17.0 meq/L) and the plasma arterial PCO2 was higher (33.8 compared to 31.2). " 08/01/1984 - "Oral rehydration therapy: efficacy of sodium citrate equals to sodium bicarbonate for correction of acidosis in diarrhoea."
5.	Hypersensitivity (Allergy) 06/08/2020 - "Exclusion criteria are: 1) previous allergic reaction to plasma exchange or its ingredients (i.e., sodium citrate), 2) two consecutive negative RT-PCR tests for SARS-CoV-2 at least 24 hours apart, 3) mild COVID-19 not requiring ICU admission and 4) terminally ill patients receiving palliative care. " 11/01/1977 - "This study demonstrated that a pluronic polyol gel containing sodium citrate is highly effective in controlling tooth hypersensitivity." 10/01/1989 - "The objective of this study was to assess the effectiveness of a dentifrice with 2% dibasic sodium citrate in poloxamer 407 in decreasing dentinal hypersensitivity. "

Related Drugs and Biologics

1.	Solutions
2.	Heparin (Liquaemin)
3.	Sodium Bicarbonate (Baking Soda)
4.	Buffers
5.	Gentamicins (Gentamicin)
6.	Potassium Citrate
7.	Poloxamer (Poloxamer 407)
8.	Caffeine (No Doz)
9.	Calcium
10.	Alkalies

Related Therapies and Procedures

1.	Therapeutics
2.	Catheters
3.	Renal Dialysis (Hemodialysis)
4.	Precision Medicine
5.	Fluid Therapy (Oral Rehydration Therapy)