Polidocanol (Laureth)

An alkyl polyglycol ether of LAURYL ALCOHOL, chemically defined as an alcohol ethoxylate having an average alkyl chain of 12–14 carbon atoms, and an ethylene oxide chain of 9 ethylene oxide units. It is used as a detergent, and medically as a local anesthetic, and as a sclerosing agent for the treatment of ESOPHAGEAL AND GASTRIC VARICES and VARICOSE VEINS.

Also Known As:

Laureth; Aethoxysclerol; Aethoxysklerol; Aetoxisclerol; Atossisclerol; Atoxysclerol; Brij 30; Brij-30; Dodecyl Ethyleneglycol Monoether; Ethoxysclerol; Hydroxypolyethoxydodecane; Laureth 9; Laureth-1; Laureth-4; Laureth-7; Laureth-9; Lauromacrogol; Lauromacrogol 400; Lauromacrogols; Lubrol 12A9; Lubrol-PX; Nonaethylene Glycol Monododecyl Ether; Nonaethyleneglycol Monododecyl Ether; Polyethylene Glycol Monododecyl Ether; Polyethylene Glycol-7-lauryl Ether; Polyoxyethylene 9-lauryl Ether; Polyoxyethylene Lauryl Ether; Polyoxyethylene(4) Lauryl Ether; Polyoxyethylene-4-dodecyl Ether; Polyoxyethylenedodecyl Ether; Tetraethylene Glycol Dodecyl Ether; Tetraethyleneglycol Lauryl Ether; Thesit; alpha-Dodecyl-omega-hydroxypoly(oxy-1,2ethanediyl); Brij30; Dodecyl Ethyleneglycol Monoethers; Ether, Nonaethyleneglycol Monododecyl; Ether, Polyethylene Glycol-7-lauryl; Ether, Polyoxyethylene 9-lauryl; Ether, Polyoxyethylene Lauryl; Ether, Polyoxyethylene-4-dodecyl; Ether, Tetraethyleneglycol Lauryl; Ethyleneglycol Monoether, Dodecyl; Laureth 1; Laureth 4; Laureth 7; Laureths; Lauryl Ether, Tetraethyleneglycol; Lubrol PX; Monododecyl Ether, Nonaethyleneglycol; Monoether, Dodecyl Ethyleneglycol; Nonaethyleneglycol Monododecyl Ethers; Polidocanols; Polyethylene Glycol 7 lauryl Ether; Polyethylene Glycol-7-lauryl Ethers; Polyoxyethylene 4 dodecyl Ether; Polyoxyethylene 9 lauryl Ether; Polyoxyethylene 9-lauryl Ethers; Polyoxyethylene Lauryl Ethers; Polyoxyethylenedodecyl Ethers; Tetraethyleneglycol Lauryl Ethers; 3,6,9,12,15,18,21,24,27-Nonaoxanonatriacontan-1-ol

Networked: 594 relevant articles (105 outcomes, 102 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Alfredson, Håkan: 13 articles (04/2011 - 07/2004)
2.	Ohberg, Lars: 9 articles (09/2008 - 06/2002)
3.	Cabrera, Juan: 5 articles (10/2009 - 11/2003)
4.	Redondo, Pedro: 5 articles (10/2009 - 11/2003)
5.	Chai, Ningli: 4 articles (01/2022 - 11/2017)
6.	Linghu, Enqiang: 4 articles (01/2022 - 11/2017)
7.	Bertanha, Matheus: 4 articles (05/2021 - 09/2016)
8.	Wang, Jian: 4 articles (01/2021 - 01/2016)
9.	Oka, Shiro: 3 articles (03/2022 - 07/2016)
10.	Tanaka, Shinji: 3 articles (03/2022 - 07/2016)

Related Diseases

1.	Cysts 02/01/2022 - "The instillation of polidocanol showed a significant reduction of the initial cyst volume (p=0.0267). " 05/14/2021 - "The instillation of polidocanol showed a significant reduction of the initial cyst volume (p < 0.001) but a persistent disease occurred in 29/32 cases (90.6%). " 01/01/2018 - "Thoughts of the safety and efficacy of EUS-guided cyst ablation with the use of lauromacrogol." 01/01/2016 - "The effects of lauromacrogol injection into rat endometrial cysts: a preliminary experimental study." 01/01/2022 - "Approximately 90 mL of chocolate-colored fluid was aspirated from the mass and 20 mL of lauromacrogol was injected in the cyst. "
2.	Hemorrhage 01/01/2021 - "Conclusion: Ultrasound-guided lauromacrogol injection is a relatively simple, safe and feasible method, which could be helpful in treating active bleeding in the immediate post-procedure period after renal biopsy." 01/01/2021 - "Background: This study aimed to describe the technique and outcomes of hemostasis for ultrasound-guided lauromacrogol injection for active bleeding after renal biopsy. " 01/01/2021 - "Patients who still had active bleeding after 30 min of compression were then injected with lauromacrogol under ultrasound guidance. " 01/01/2021 - "Ultrasound-Guided Lauromacrogol Injection for the Treatment of Active Bleeding After Renal Biopsy." 01/01/2018 - "The average injection sites were reduced in the transparent cap-assisted group compared with the control group (1.2±0.4 vs. 1.4±0.05, P=0.000), whereas no difference was observed in the dosage of lauromacrogol (16.97±4.91 vs. 16.85±4.57, P=0.662) and the hemorrhage that occurred during injection made no difference (50.8 vs. 61.0%, P=0.276); yet, salvage hemostasis methods were used in only nine patients in the transparent cap-assisted group compared with 17 patients in the control group (25.0 vs. 38.7%, P=0.0936). "
3.	Varicose Veins (Varicose Vein) 12/10/2021 - "Following polidocanol 1% use, there may be a possible improvement in QoL as assessed using the VEINES-QOL/Sym questionnaire (MD 12.41, 95% CI 9.56 to 15.26; 3 studies, 299 participants; very low-certainty evidence), and possible improvement in varicose vein symptoms as assessed using the Venous Clinical Severity Score (VCSS) (MD -3.25, 95% CI -3.90 to -2.60; 2 studies, 223 participants; low-certainty evidence). " 06/01/2017 - "Improvement in patient-reported outcomes of varicose veins following treatment with polidocanol endovenous microfoam." 01/01/2017 - "Corrigendum to Improvement in patient-reported outcomes of varicose veins following treatment with polidocanol endovenous microfoam. " 04/10/1990 - "Varices were injected with ethoxysclerol 1% in weekly sessions if possible until they were completely eradicated. " 12/10/2021 - "Three RCTs investigating higher concentrations of polidocanol foam indicated the rate of residual varicose veins may be slightly decreased in the polidocanol 3% foam group compared to 1% (RR 0.67, 95% CI 0.43 to 1.04; 3 studies, 371 participants; moderate-certainty evidence). "
4.	Pain (Aches) 10/27/2023 - "The objective of this study was to retrospectively evaluate the effectiveness of polidocanol in managing pain, swelling, functional limiting and cosmetic disorders in patients with venous malformations (VMs). " 08/20/2023 - "Embolization for PCS resulted in pain relief in 90% of patients; the use of polidocanol did not demonstrate changes in the clinical outcome. " 04/01/2023 - "Patients treated with polidocanol had less pain after the treatment and a better clearance rate in the photos with augmented reality. " 09/01/2015 - "Polidocanol foam caused fewer severe reactions, including pain, during and after injection. " 12/01/1995 - "There was neither pain during instillation of 3% polidocanol nor any other complication. "
5.	Sclerosis 09/01/2002 - "Sonographically guided percutaneous injection of 1% polidocanol for sclerosis of peripheral vascular lesions is simple, effective, and safe. " 09/01/2020 - "In this paper, we report on an improved surgical technique involving lauromacrogol sclerosis directly under laparoscopic fenestration. " 05/01/2021 - "Sclerosis with foam and liquid polidocanol were superior to the other groups, but specially polidocanol foam at the expense of greater frequency of adverse events." 11/01/2004 - "[Allergic respiratory disorders and vein sclerosis with lauromacrogol 400]." 05/01/2003 - "The procedures were performed on a out-patient basis with ultrasound assistance and using 3% Polidocanol for sclerosis. "

Related Drugs and Biologics

1.	Sclerosing Solutions (Sclerosing Agents)
2.	Polidocanol (Laureth)
3.	Solutions
4.	Epinephrine (Adrenaline)
5.	Ethanol (Ethyl Alcohol)
6.	Fibrin Tissue Adhesive (Fibrin Sealant)
7.	ethanolamine oleate (Ethamolin)
8.	Cyanoacrylates
9.	Bleomycin (Blenoxane)
10.	Sodium

Related Therapies and Procedures

1.	Sclerotherapy
2.	Therapeutics
3.	Injections
4.	Solid-State Lasers
5.	Punctures