Abstract | OBJECTIVE: To compare the efficacy and safety of sclerosing agents injected in dorsal veins of rabbit ears. METHODS: Sixty ears of 30 rabbits were randomly allocated in: 1% liquid polidocanol, 1% polidocanol foam, 0.2% polidocanol- glucose 70% solution, glucose 75% or 0.9% saline. Outcomes included efficacy ( luminal occlusion), complications ( phlebitis, neovascularization, ulceration at the puncture site, necrosis and local inflammation) and histology ( sclerosis, recanalization vein and surrounding tissues inflammation, blood extravasation, recanalization, lymphangiogenesis, destruction of cartilage and neoangiogenesis). RESULTS:
Sclerosis was superior in Foam Group (76.9%), but also with 30.7% necrosis (p = 0.003), 46.15% ulceration (p = 0.003), and 69.2% local inflammation (p < 0.0001). Neovascularization were similar. Histology showed 38.5% phlebitis (p = 0.004) and necrosis (p = 0.03) in the foam group. CONCLUSIONS:
Sclerosis with foam and liquid polidocanol were superior to the other groups, but specially polidocanol foam at the expense of greater frequency of adverse events.
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Authors | Carlos Eduardo Pinheiro Lucio Filho, Matheus Bertanha, Marcela Polachini Prata, Lídia Raquel de Carvalho, Rodrigo Gibin Jaldin, Marcone Lima Sobreira, Jan Janzen, Winston Bonetti Yoshida |
Journal | Phlebology
(Phlebology)
Vol. 36
Issue 4
Pg. 303-312
(May 2021)
ISSN: 1758-1125 [Electronic] England |
PMID | 33030404
(Publication Type: Journal Article)
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Chemical References |
- Glucose
- Polidocanol
- Sclerosing Solutions
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Topics |
- Animals
- Rabbits
- Glucose
- Polidocanol
- Sclerosing Solutions
(adverse effects)
- Sclerotherapy
(adverse effects)
- Treatment Outcome
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