Silybin (Lagosa)

The major active component of silymarin flavonoids extracted from seeds of the MILK THISTLE, Silybum marianum; it is used in the treatment of HEPATITIS; LIVER CIRRHOSIS; and CHEMICAL AND DRUG INDUCED LIVER INJURY, and has antineoplastic activity; silybins A and B are diastereomers.

Also Known As:

Lagosa; 2,3-Dehydrosilybin; Alepa-forte; Ardeyhepan; Cefasilymarin; Durasilymarin; Hepa-Merz Sil; Hepa-loges; HepaBesch; Hepar-Pasc; Heparsyx; Heplant; Legalon Forte; Silibin; Silibinin; Silibinin A; Silibinin B; Silybin A; Silybin B; Silybinin; 2,3 Dehydrosilybin; Alepa forte; Hepa Merz Sil; Hepa loges; Hepar Pasc; 4H-1-Benzopyran-4-one, 2-((2R,3R)-2,3-dihydro-3-(4-hydroxy-3-methoxyphenyl)-2-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-, (2R,3R)-

Networked: 995 relevant articles (173 outcomes, 313 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Agarwal, Rajesh: 100 articles (01/2022 - 03/2002)
2.	Agarwal, Chapla: 51 articles (01/2022 - 03/2002)
3.	Singh, Rana P: 51 articles (01/2017 - 03/2002)
4.	Ikejima, Takashi: 43 articles (08/2022 - 09/2006)
5.	Onodera, Satoshi: 33 articles (01/2020 - 09/2006)
6.	Deep, Gagan: 30 articles (01/2022 - 06/2006)
7.	Hayashi, Toshihiko: 22 articles (08/2022 - 03/2013)
8.	Raina, Komal: 20 articles (01/2022 - 09/2007)
9.	Liu, Weiwei: 18 articles (11/2021 - 01/2012)
10.	Tashiro, Shin-ichi: 17 articles (02/2016 - 09/2006)

Related Diseases

1.	Neoplasms (Cancer) 11/01/2016 - "Over the years, pre-clinical studies have shown that silibinin (a flavonolignan isolated from the seeds of milk thistle, Silybum marianum) has strong preventive and therapeutic efficacy against various epithelial cancers, including CRC. " 09/01/2010 - "Recent preclinical studies have also shown strong efficacy of silibinin to target cancer cell's migratory and invasive characteristics as well as their ability to metastasize to distant organs. " 01/01/2018 - "Considering the anti-hepatotoxic activity of silibinin and its strong preventive and anti-cancer efficacy against various epithelial cancers, we investigated the efficacy of silibinin against human HCC and HUVEC cell lines. " 01/01/2016 - "Silibinin, a natural agent from milk thistle seeds, has shown strong efficacy against several cancers including ultraviolet radiation-induced skin (squamous) cancer; however, its potential activity against BCC is not yet examined. " 01/01/2013 - "Overall, these results clearly suggest that the anti-cancer efficacy of silybin could be significantly enhanced through structural modifications, and identify strong anti-cancer efficacy of silybin derivatives, namely DHS, 7OM, and 7OG, signifying that their efficacy and toxicity should be evaluated in relevant pre-clinical cancer models in rodents."
2.	Inflammation (Inflammations) 01/01/2022 - "Protective effects of silibinin on LPS-induced inflammation in human periodontal ligament cells." 01/01/2017 - "These results further confirmed that absence of the p53 allele predisposes mice to photodamage and photocarcinogenesis, and established that silibinin mediates its protection against UVB-induced photodamage, inflammation and photocarcinogenesis partly through p53 activation." 01/01/2019 - "Silibinin possesses the efficacy of anticancer and anti-inflammation. " 10/06/2023 - "Overall, this study demonstrates the promising therapeutic properties of silibinin in modulating macrophage function and inflammation." 01/01/2023 - "This study highlights silibinin-mTOR/NF-κB axis plays an important role in the control of inflammation in PMECs, and suggests that silibinin may be an effective dietary strategy to alleviate the inflammatory response in lactating sow."
3.	Carcinogenesis 11/24/2015 - "In earlier studies, we have reported that natural flavonolignan silibinin exerts strong chemopreventive efficacy against UVB-induced skin damage and carcinogenesis; however mechanistic studies are still being actively pursued. " 06/01/2015 - "Consistent with this, we and others have studied and established the notable efficacy of natural flavonolignan silibinin against UVB-induced skin carcinogenesis. " 07/16/2004 - "Together, for the first time, our results demonstrate the role of mitochondrial apoptotic machinery and MAPK signaling cascade in silibinin-caused increase as well as protection in UVB-induced apoptosis in A431 cells, and suggest that similar mechanisms might be involved in preventive efficacy of silibinin against UVB-induced skin tumorigenesis." 01/01/2014 - "The present study was designed to investigate underlying molecular mechanism for antitumorigenic potential of silibinin against chemically induced skin tumorigenesis in Swiss albino mice. " 09/01/2012 - "The present study investigated the potential of silibinin as a chemopreventive agent in colon carcinogenesis. "
4.	Prostatic Neoplasms (Prostate Cancer) 02/01/2004 - "Recently, due to its non-toxic and mechanism-based strong preventive/therapeutic efficacy, silibinin has entered in phase I clinical trial in prostate cancer patients." 01/01/2020 - "This study was designed to find out the potential target of Silybin on prostate cancer and explore the relative mechanisms. " 08/01/2019 - "The goal of the present study was to assess the pharmacologic effect of SEE and its bioactive components silibinin and silychristine when administrated alone or in combination with DXR in the human prostate cancer cells (PC-3). " 02/15/2016 - "This study aims to systematically explore the alkylation effect of 7-OH in silibinin and 2,3-dehydrosilibinin on the antiproliferative potency toward three prostate cancer cell lines. " 10/01/2007 - "Recent studies have shown that silibinin induces p21/Cip1 and p27/Kip1 and G1 arrest in different prostate cancer cells irrespective of p53 status; however, biological significance and mechanism of such induction have not been studied. "
5.	Non-alcoholic Fatty Liver Disease 03/01/2013 - "Silibinin was effective in ameliorating IR in NAFLD rats. " 01/01/2017 - "We provide new insights about the direct protective effects of the nutraceutic silybin on hepatocytes mimicking in vitro NAFLD progression." 01/01/2023 - "In this study we investigated how silybin regulated P450s activity during NAFLD. " 01/01/2021 - "Silibinin improves nonalcoholic fatty liver by regulating the expression of miR‑122: An in vitro and in vivo study." 03/01/2020 - "This study aims to investigate the metabolic regulation by silybin of nonalcoholic fatty liver disease (NAFLD). "

Related Drugs and Biologics

1.	Silymarin
2.	Flavonoids
3.	Cytokines
4.	Lipids
5.	Cisplatin (Platino)
6.	Lipopolysaccharides
7.	milk-thistle extract
8.	Doxorubicin (Adriamycin)
9.	Quercetin
10.	Polyphenols

Related Therapies and Procedures

1.	Therapeutics
2.	Oral Administration
3.	Chemoprevention
4.	Drug Therapy (Chemotherapy)
5.	Radiotherapy