Saline Solution

A crystalloid solution that contains 9.0g of SODIUM CHLORIDE per liter of water. It has a variety of uses, including: as a CONTACT LENS SOLUTION, in OPHTHALMIC SOLUTIONS and NASAL LAVAGE, in wound irrigation, and for FLUID THERAPY.

Also Known As:

Networked: 8953 relevant articles (376 outcomes, 929 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Alam, Hasan B: 31 articles (10/2021 - 01/2006)
2.	Wang, Ping: 25 articles (01/2022 - 03/2002)
3.	Wang, Wei: 19 articles (01/2022 - 11/2004)
4.	Wang, Jing: 17 articles (11/2021 - 08/2010)
5.	Lin, Mao-Tsun: 16 articles (01/2021 - 09/2003)
6.	Li, Yongqing: 15 articles (01/2021 - 02/2008)
7.	Williams, Aaron M: 14 articles (10/2021 - 01/2018)
8.	Liu, Baoling: 14 articles (01/2021 - 02/2008)
9.	Traber, Daniel L: 14 articles (12/2013 - 05/2005)
10.	Zhang, Wei: 13 articles (01/2022 - 01/2006)

Related Diseases

1.	Pain (Aches) 01/01/2021 - "Subgroup analysis of high-quality studies revealed a statistically significant reduction in postprocedural pain with normal saline (SMD, -0.65; 95% CI, -1.14 to -0.16). " 12/01/2023 - "The combination of fat and PRP was the only treatment that resulted in a significantly greater reduction in pain compared with 0.9% saline ( P = 0.003). " 09/01/2019 - "The WOMAC pain score also improved from baseline (14.5 ± 1.3) to over 6month 7.00 ± 4.24 (p < 0.001) in platelet-rich plasma knee while in the normal saline knee, no significant change occurred from baseline to six months (10.2 ± 1.2 to 10.05 ± 1.23). " 12/01/2022 - "In group II, transalveolar extractions/surgical extraction of impacted mandibular III molars were carried out under copious irrigation with sterile ozonated water on study side and normal saline irrigation on control side evaluated by independent observer on 2nd, 4th and 7th day for the efficacy of ozonated water/oil in reducing pain and enhancing healing in post-dental extraction sockets. " 12/01/2022 - "Post Laparoscopy Pain Reduction Project I (POLYPREP I): intraperitoneal normal saline instillation-a randomised controlled trial."
2.	Wounds and Injuries (Trauma) 11/01/2010 - "The ASCs in PRP-treated wounds exhibited a significant 11.2% improvement in wound healing compared with saline solution. " 01/16/2013 - "Water is a safe and effective alternative to sterile normal saline for wound irrigation prior to suturing: a prospective, double-blind, randomised, controlled clinical trial." 01/01/1997 - "When bacterial contamination has been eradicated and the wound is clean, we resume wound cleansing with normal saline." 08/02/2023 - "Also, one study reported no impact on wound healing when tap water or normal saline were used for cleansing; four established that tap water was cost-effective compared to normal saline; and one demonstrated increased patient satisfaction when tap water was used for wound irrigation. " 02/27/2023 - "Therefore, we conducted this study to compare PRP dressings with normal saline dressings in treating chronic wounds. "
3.	Neoplasms (Cancer) 09/01/2010 - "In vivo anti-tumor activity of the DOX/FA-PEG-P(HB-HO) NPs showed a much better therapeutic efficacy in inhibiting tumor growth, and the final mean tumor volume was 178.91+/-17.43 mm(3), significantly smaller than normal saline control group (542.58+/-45.19 mm(3)). " 05/01/2002 - "Furthermore, a significant reduction in macroscopically visible tumor number with MDM2-AS ODN treatments (100 or 200 microg) in comparison to MDM2-SE ODN or saline solution treatment (both p=0.009) was observed for the first time. " 08/01/1987 - "All groups treated with 2-DG had a significant reduction in tumor weight of 50% to 70% when compared with saline solution-treated controls. " 11/29/2019 - "Finally, we compared the therapeutic efficacy of the PirNP-AdSCs on KP1N-derived tumor growth with that of treatments of AdSCs alone, PirNPs alone or normal saline (control) in immunodeficient mice. " 01/01/2015 - "To assess the therapeutic efficacy, tumor-bearing rats were intravenously administered (188)Re-liposome or normal saline followed by monitoring of the tumor growth and animal survival time. "
4.	Hemorrhage 01/01/2018 - "Pretreatment SynthoPlate transfusion resulted in significant reduction of blood loss following hemorrhage, compared with control particles or normal saline treatment (0.86 ± 0.16 g control particles [CP] vs. 0.84 ± 0.13 g normal saline [NS] vs. 0.68 ± 0.09 g SynthoPlate, p < 0.005). " 07/01/2013 - "The present study in rats showed that the plasma volume-expanding effect after an infusion of 0.9% NaCl was smaller in a septic/SIRS state than after hemorrhage and in a normal state. " 01/01/2013 - "In this study group, the application of 4 ml of ABS instead of isotonic saline solution lessened bleeding." 04/01/2023 - "After switching to red dichromatic imaging mode 2 and washing the bile duct with saline solution, the bleeding point was observed in darker yellow than the surrounding blood, allowing the identification of the bleeding point. " 06/01/2020 - "Histopathological analysis showed that a bleeding appearance was observed in the L. lactis group, and the histology scores in the L. lactis group were significantly higher than those in the normal saline group. "
5.	Bronchiolitis 01/01/2010 - "In conclusion, all treatment modalities used in this study, including a total of 8 ml normal saline inhalation at 30-min interval showed clinically significant and swift improvement in mildly affected ambulatory infants with acute bronchiolitis." 03/01/2016 - "A single nasal irrigation with saline solution significantly improved oxygen saturation in infants with bronchiolitis." 08/01/2023 - "Aim Compare the efficacy of nebulized hypertonic saline and normal saline in the treatment of infants hospitalized for bronchiolitis. " 08/01/2023 - "Efficacy of nebulized hypertonic saline versus normal saline in the treatment of acute bronchiolitis in inpatient infants." 01/01/2018 - "We undertook a cumulative meta-analysis for the efficacy of hypertonic saline (HS) compared to normal saline (NS) inhalations or no inhalations as controls in bronchiolitis. "

Related Drugs and Biologics

1.	Solutions
2.	Lidocaine (Xylocaine)
3.	Glucose (Dextrose)
4.	Saline Solution
5.	Ringer's Lactate
6.	Heparin (Liquaemin)
7.	Epinephrine (Adrenaline)
8.	Albumins
9.	Bupivacaine (Bupivacaine Hydrochloride)
10.	Hyaluronic Acid (Hyaluronan)

Related Therapies and Procedures

1.	Therapeutics
2.	Injections
3.	Catheters
4.	Resuscitation
5.	Laparoscopic Cholecystectomy