Transforming Growth Factor-beta Type I Receptor

A transmembrane serine-threonine kinase that forms a heteromeric complex with TYPE II TGF-BETA RECEPTORS to bind TGF-BETA and regulate a variety of physiological and pathological processes including CELL CYCLE ARREST; CELL PROLIFERATION; CELL DIFFERENTIATION; WOUND HEALING; EXTRACELLULAR MATRIX production, immunosuppression and ONCOGENESIS.

Also Known As:

Receptor, Transforming Growth Factor-beta Type I; Activin Receptor-like Kinase 5; Receptor, TGF-beta Type I; Serine-Threonine-Protein Kinase Receptor R4; TGF-beta RPK; TGF-beta Receptor Protein Kinase; TGF-beta Type I Receptor; TGF-beta Type I Receptors; TGFBR1; TbetaR-I Kinase; Transforming Growth Factor beta Receptor I; Transforming Growth Factor, beta Receptor 1; Type I TGF-beta Receptor; Type I TGF-beta Receptors; Activin Receptor like Kinase 5; Kinase, TbetaR-I; Serine Threonine Protein Kinase Receptor R4; TGF beta Receptor Protein Kinase; TGF beta Type I Receptor; TGF beta Type I Receptors; TbetaR I Kinase; Type I TGF beta Receptor; Type I TGF beta Receptors

Networked: 565 relevant articles (12 outcomes, 71 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Pasche, Boris: 20 articles (01/2014 - 09/2003)
2.	Sun, Zhi-Jun: 11 articles (01/2021 - 10/2012)
3.	Zhang, Lu: 8 articles (01/2021 - 12/2011)
4.	Kulkarni, Ashok B: 8 articles (01/2018 - 07/2009)
5.	Bian, Yansong: 8 articles (07/2013 - 05/2005)
6.	Dietz, Harry C: 7 articles (01/2022 - 08/2006)
7.	Zhang, Wen-Feng: 7 articles (11/2018 - 01/2015)
8.	Kaklamani, Virginia: 7 articles (05/2010 - 02/2004)
9.	Morisaki, Takayuki: 6 articles (01/2022 - 10/2009)
10.	Li, Qinglei: 6 articles (01/2018 - 10/2011)

Related Diseases

1.	Neoplasms (Cancer) 05/13/2020 - "The data of this study indicated that the decreased expression of miR-3607 in HCC predicts poor prognosis and the overexpression of miR-3607 in HCC cells can suppress the tumor progression by targeting TGFBR1. " 01/01/2020 - "This study uncovers a novel underlying molecular mechanism of PCAT6-miR-185-5p-TGFBR1/2-TGF-β signaling axis in promoting tumor progression in OS, which indicates that PCAT6 may serve as a promising prognostic factor and therapeutic target again OS." 01/01/2019 - "The present study illustrates that miR-140-5p functions as a tumor suppressor in the occurrence and development of WT via targeting TGFBR1, which provides theoretical foundation for serving miR-140-5p as a new diagnosis marker even a therapeutic target for WT." 01/01/2019 - "Overall, these studies indicate that TGFβ signaling through TGFBR1/ALK5 in the endometrium is required for endometrial homeostasis, tumor suppression, and postpartum endometrial regeneration." 11/25/2016 - "This study shows that TFAP2C promoted tumor progression by upregulation of TGFBR1 and consequent activation of PAK1 signaling."
2.	Neoplasm Metastasis (Metastasis) 11/13/2012 - "The activity of TGF-β on stromal cells increases the efficiency of organ colonization by CRC cells, whereas mice treated with a pharmacological inhibitor of TGFBR1 are resilient to metastasis formation. " 04/29/2010 - "However, TGFBR1*6A was significantly associated with less metastasis. " 08/01/2010 - "These findings suggested that the TbetaR-I kinase inhibitor with S1 is useful for the treatment of scirrhous gastric carcinoma with LN metastasis. " 06/08/2015 - "Our study reveals that the TGFBR1 inhibitor SD208 effectively reduces prostate cancer bone metastases. " 01/01/2021 - "The CP-GEP model combines clinicopathological features (age and Breslow thickness) with the expression of eight target genes involved in melanoma metastasis (ITGB3, PLAT, SERPINE2, GDF15, TGFBR1, LOXL4, CXCL8 and MLANA). "
3.	Breast Neoplasms (Breast Cancer) 11/11/2015 - "Our study demonstrates that women who carry the TGFBR16A allele are at lower risk of developing breast cancer. " 01/01/2010 - "In conclusion, our study shows that there is no association between TGFBR16A and breast cancer risk." 09/11/2007 - "TGFB1 and TGFBR1 polymorphisms and breast cancer risk in the Nurses' Health Study." 07/19/2022 - "The TGFBR16A allele has been associated with increased breast cancer risk in women, OR 1.15 (95% CI 1.01-1.31). " 07/19/2022 - "TGFBR16A as a modifier of breast cancer risk and progression: advances and future prospects."
4.	Fibrosis (Cirrhosis) 12/01/2023 - "In vivo experiments revealed that EF alleviated myocardial fibrosis, improved cardiac dysfunction after MI and downregulated the TGFBR1 signaling in a dose-dependent manner. " 12/01/2023 - "The goal of this study was to look into how EF affected the signaling of the TGF-receptor 1 (TGFBR1) in myocardial fibrosis after MI. " 10/01/2011 - "Studies in a wide range of experimental models have demonstrated the involvement of the canonical activin receptor-like kinase 5/Smad3 pathway in fibrosis. " 12/01/2023 - "EF attenuated myocardial fibrosis post-MI by directly suppressing TGFBR1 and its downstream signaling pathway." 12/01/2023 - "Lastly, knocking down of Tgfbr1 partially reversed the inhibitory activity of EF on myocardial fibrosis in MI mice. "
5.	Squamous Cell Carcinoma of Head and Neck 05/08/2023 - "Furthermore, a novel small molecule TGFBR1 inhibitor was evaluated in HNSCC cell lines. " 03/05/2018 - "The effects of TIM3 on regulatory T cells (Tregs) and macrophages were detected by utilizing the Tgfbr1/Pten 2cKO HNSCC mouse model. " 01/01/2018 - "We first demonstrated that Notch1 signaling was activated in a Tgfbr1/Pten-knockout HNSCC mouse model. " 08/01/2017 - "Furthermore, we found that blockade of STAT3 signaling downregulated PD-1/PD-L1 in a Tgfbr1/Pten 2cKO HNSCC mouse model. " 01/01/2017 - "To determine the underlying mechanism of TIM3 in immune response during HNSCC progression, we utilized the Tgfbr1/Pten 2cKO HNSCC mouse model with TIM3 overexpression. "

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Related Therapies and Procedures

1.	Therapeutics
2.	Chemoradiotherapy
3.	Filtering Surgery
4.	Lasers (Laser)
5.	Chemoprevention