Imiquimod (Aldara)

A topically-applied aminoquinoline immune modulator that induces interferon production. It is used in the treatment of external genital and perianal warts, superficial CARCINOMA, BASAL CELL; and ACTINIC KERATOSIS.

Also Known As:

Networked: 3256 relevant articles (549 outcomes, 559 trials/studies)

Relationship Network

Drug Context: Research Results

Experts

1.	Li, Ping: 23 articles (05/2022 - 01/2015)
2.	Berman, Brian: 21 articles (09/2018 - 05/2002)
3.	Wang, Yan: 20 articles (05/2022 - 01/2015)
4.	Lu, Chuanjian: 16 articles (01/2022 - 01/2017)
5.	Wang, Gang: 16 articles (01/2022 - 01/2016)
6.	Stockfleth, E: 15 articles (08/2016 - 10/2000)
7.	Han, Ling: 14 articles (01/2021 - 07/2016)
8.	Kabashima, Kenji: 13 articles (10/2022 - 07/2014)
9.	Sato, Shinichi: 13 articles (01/2022 - 02/2013)
10.	Ahmad, Sheikh F: 12 articles (01/2022 - 09/2015)

Related Diseases

1.	Psoriasis (Pustulosis Palmaris et Plantaris) 01/01/2017 - "On the other hand, our in vivo studies demonstrated that PSORI-CM02 dramatically reduced psoriasis area and severity index scores and lesion temperature in imiquimod-induced psoriatic mice. " 01/01/2023 - "This iontophoresis patch demonstrates an effective treatment of an imiquimod-induced psoriasis mouse. " 05/01/2021 - "Imiquimod (IMQ) induced human-like psoriasis in mice has been shown to be effective in testing and development of novel treatments. " 09/01/2020 - "We previously reported that MDSCs had protective effects in a murine model of imiquimod (IMQ)-induced psoriasis. " 01/10/2024 - "Qingre Lishi Decoction ameliorates imiquimod-induced psoriasis-like skin lesions in SKH-1 mice by regulating the Treg-DC-Th17 axis and inhibiting MAPK-mediated DC maturation."
2.	Warts (Wart) 10/01/2002 - "Published studies indicate that imiquimod results in complete clearance of warts in more than 50% of patients. " 01/01/2001 - "In three trials complete clearance of warts at the end of treatment plus no recurrence occurred in 37% of patients treated with imiquimod 5% cream and 4% of those treated with placebo. " 01/01/2001 - "In five trials with HIV-negative patients complete clearance of warts at the end of treatment occurred in 51% of patients treated with imiquimod 2% or 5% cream and 6% of placebo treated patients. " 08/01/1999 - "Preliminary results of a vehicle-controlled study showed that the rate of partial clearance of warts (defined as a reduction in baseline wart area of >50%) [38%] was significantly higher with imiquimod 5% cream than with vehicle cream; however, the rate of complete clearance was not significantly higher than with vehicle cream. " 07/01/1999 - "Post-marketing trials using imiquimod demonstrated that patients who experience complete clearance of either new or recalcitrant warts tend to remain clear for longer periods as compared to other treatment modalities. "
3.	Neoplasms (Cancer) 12/01/2013 - "Topical imiquimod 5% cream may be beneficial in most cases of genital intraepithelial neoplasia, especially CIN, with persistent HPV following surgical treatment." 02/01/2013 - "Topical TLR7 agonists such as imiquimod are highly effective for the treatment of dermatological malignancies; however, their efficacy in the treatment of nondermatological tumors has been less successful. " 01/01/2019 - "Imiquimod has been proven to be effective in the regression of vulvar intraepithelial neoplasia (VIN) and vaginal intraepithelial neoplasia (VAIN). " 09/01/2004 - "Imiquimod treatment leads either to complete regression or to a significant reduction of the tumors. " 09/01/2002 - "To investigate the efficacy of topical treatment with imiquimod 5% cream, an immune response modifier, in patients with vulvar intraepithelial neoplasia (VIN) 2/3. Fifteen women (aged 35-51) with histologically proven multifocal VIN 2/3 without invasion, were entered into a prospective, observational, pilot study. "
4.	Inflammation (Inflammations) 12/01/2022 - "ADE treatment significantly attenuated skin inflammation and improved skin integrity in imiquimod-treated mice by suppressing keratinocyte hyperproliferation, inhibiting the infiltration of immune cells, and downregulating the expression of psoriatic markers. " 09/01/2023 - "Piper retrofractum ameliorates imiquimod-induced skin inflammation via modulation of TLR4 axis and suppression of NF-κB activity." 10/21/2021 - "BRD4 expression was upregulated in injured skin on the back of imiquimod-induced mice and (+)-JQ1 relieved the skin injury by suppressing the inflammation and promoting apoptosis of keratinocytes. " 01/01/2021 - "2'-Hydroxycinnamaldehyde ameliorates imiquimod-induced psoriasiform inflammation by targeting PKM2-STAT3 signaling in mice." 12/26/2018 - "Here, we addressed the contribution of regulatory Foxp3+ T cells (Treg cells) in psoriasiform skin inflammation and remission using the Aldara-skin inflammation model in combination with the inducible depletion of Foxp3+ Treg cells. "
5.	Actinic Keratosis 09/01/2019 - "Most of the LSR were mild-to-moderate in intensity at Week 2 and had resolved by Week 8. Imiquimod 3.75% effectively detected and cleared both the clinical and subclinical actinic keratosis lesions across the entire sun-exposed field in this cohort of Greek patients. " 01/01/2017 - "To the authors' knowledge, this is the first report of conjunctival actinic keratosis being treated with and successfully eradicated by topical imiquimod." 04/01/2018 - "A 12-day course of imiquimod 5% proved effective for the treatment of actinic keratosis. " 08/01/2017 - "Increased number of mast cells in the dermis in actinic keratosis lesions effectively treated with imiquimod." 01/01/2011 - "Although its mechanism of action has not been entirely elucidated yet, imiquimod 5% cream has been shown to be an efficient, long-lasting and safe therapy for multiple actinic keratoses in non-immunosuppressed patients and in transplant recipients. "

Related Drugs and Biologics

1.	Fluorouracil (Carac)
2.	Imiquimod (Aldara)
3.	Interleukin-17 (Interleukin 17)
4.	Cytokines
5.	1-phenyl-3,3-dimethyltriazene (PDT)
6.	Interferons
7.	Antiviral Agents (Antivirals)
8.	Vaccines
9.	Podophyllotoxin (Condylox)
10.	Inflammasomes

Related Therapies and Procedures

1.	Therapeutics
2.	Photochemotherapy (Photodynamic Therapy)
3.	Aftercare (After-Treatment)
4.	Cryotherapy (Therapy, Cold)
5.	Curettage