Pamidronate (Aredia)

An aminobisphosphonate that inhibits BONE RESORPTION and is used for the treatment of osteolytic lesions, bone pain, and severe HYPERCALCEMIA associated with malignancies.

Also Known As:

Aredia; (3-Amino-1-hydroxypropylidene)-1,1-biphosphonate; 1-Hydroxy-3-aminopropane-1,1-diphosphonic acid; AHPrBP; Amidronate; Amino-1-hydroxypropane-1,1-diphosphonate; Aminohydroxypropylidene Diphosphonate; Aminopropanehydroxydiphosphonate; Pamidronate Calcium; Pamidronate Disodium; Pamidronate Monosodium; Pamidronic Acid; 1 Hydroxy 3 aminopropane 1,1 diphosphonic acid; Amino 1 hydroxypropane 1,1 diphosphonate

Networked: 1590 relevant articles (273 outcomes, 301 trials/studies)

Relationship Network

Drug Context: Research Results

Organic Chemicals: 133
- Organophosphorus Compounds: 300
  - Organophosphonates: 424
    - Diphosphonates: 11565
      - Pamidronate: 1590

Experts

1.	Rauch, Frank: 28 articles (12/2020 - 01/2002)
2.	Glorieux, Francis H: 28 articles (09/2017 - 11/2002)
3.	Lipton, Allan: 15 articles (07/2017 - 02/2003)
4.	Coleman, Robert E: 14 articles (11/2012 - 12/2002)
5.	Terpos, Evangelos: 12 articles (06/2019 - 01/2003)
6.	Clemons, Mark: 9 articles (11/2021 - 01/2004)
7.	Body, Jean-Jacques: 9 articles (06/2019 - 02/2003)
8.	Coleman, R E: 8 articles (05/2010 - 01/2000)
9.	Land, Christof: 7 articles (07/2009 - 01/2004)
10.	Travers, Rose: 7 articles (03/2007 - 11/2002)

Related Diseases

1.	Pain (Aches) 05/01/2019 - "His bone pain resolved completely after 9 months of low-dose IV pamidronate. " 10/01/2004 - "Pamidronate was associated with a marked improvement in function and well-being, and a reduction of pain and use of other medications in all patients, with no significant adverse effects. " 01/01/1994 - "Marked improvement in bone pain was observed in 44% of patients receiving pamidronate compared to 30% in controls (p = 0.025). " 01/01/2014 - "The proportion of responders, changes in worst pain, and pain interference with daily function were also significantly improved for pamidronate 180 mg compared with placebo. " 04/01/2009 - "Pamidronate was associated with a reduction in bone pain and a significant reduction in BALP in all patients at the end of follow-up (P < 0.02). "
2.	Hypercalcemia (Milk Alkali Syndrome) 08/01/1991 - "All three are useful for the treatment of hypercalcemia, but pamidronate seems to be the most effective. " 06/01/1996 - "We report two cases of PHPT in which intravenous pamidronate effectively reduced hypercalcemia and significantly improved the clinical symptoms. " 12/01/2002 - "Although treatment of hypercalcemia with pamidronate is palliative, it is effective against the deterioration of quality of life." 09/01/1998 - "The episode resolved readily with administration of pamidronate, an outcome suggesting that this is effective treatment of hypercalcemia of this origin. " 10/01/1997 - "Followed by hydration with saline, pamidronate is effective for the control of symptomatic hypercalcemia. "
3.	Breast Neoplasms (Breast Cancer) 01/01/2000 - "Although pamidronate is effective in preventing a feared, common adverse outcome in metastatic breast cancer, its use is associated with high incremental costs per adverse event avoided. " 01/01/2000 - "Pamidronate is effective in reducing bony complications in patients with metastatic breast cancer who have known osteolytic lesions. " 07/01/2011 - "In a head-to-head trial in patients with breast cancer, ZOL demonstrated efficacy at least comparable with, and some benefits beyond those of, pamidronate. " 01/01/1991 - "The results indicate that reduced skeletal morbidity in breast cancer patients during pamidronate treatments is associated with an improvement in selective aspects of quality of life." 01/01/2016 - "A preliminary study of pamidronic acid downregulation of angiogenic factors IGF-1/PECAM-1 expression in circulating level in bone metastatic breast cancer patients."
4.	Neoplasm Metastasis (Metastasis) 11/01/2008 - "Findings from this study show that pamidronate in dose 90 mg is effective in treatment of different stages of bone metastases. " 08/01/2001 - "Intravenous pamidronate is currently the standard treatment for patients with bone metastases, and is effective in reducing the frequency of a variety of skeletal-related events. " 06/01/2016 - "As pamidronate was the only bone agent available in the center, she received it for 4 months (before a dialysis session), during which time the bone metastases stabilized. " 12/01/2013 - "Patients with biochemically defined low risk bone metastases were randomized to 4 weekly (control arm) or 12 weekly (de-escalating arm) pamidronate for 1 year. " 08/01/2011 - "She was diagnosed to have osteolytic bone metastases 5 years prior to admission, and had been administered pamidronate with a total dose of approximately 6800 mg. "
5.	Neoplasms (Cancer) 03/02/1987 - "Efficacy of aminohydroxypropylidene diphosphonate in the treatment of malignancy-associated hypercalcaemia." 01/01/2014 - "This study sought to quantify in vitro antiproliferative effects of pamidronate in feline cancer cells and assess feasibility of use of pamidronate in cats by assessing short-term toxicity and dosing schedule in cats with bone-invasive cancer. " 01/01/2005 - "The purpose of this study was to evaluate the clinical safety of pamidronate when administered at a mean dosage of 1.0 mg/kg IV q28d in 33 tumor-bearing dogs. " 07/01/2001 - "This model provides opportunity to specifically study effects on osteoclast formation and findings suggest that pamidronate decreases the number of osteoclasts at sites of 2472 tumor by decreasing the number of osteoclast precursor cells at the level of myeloid precursors." 01/01/2021 - "We find that Vγ2Vδ2 T cells express PD-1, CTLA-4, LAG-3, and TIM-3 inhibitory receptors during the 14-day ex vivo expansion period, and PD-1, LAG-3, and TIM-3 upon subsequent stimulation by pamidronate-treated tumor cells. "

Related Drugs and Biologics

1.	Diphosphonates (Bisphosphonates)
2.	Zoledronic Acid (Zometa)
3.	Pamidronate (Aredia)
4.	Clodronic Acid (Clodronate)
5.	Alendronate (Alendronate Sodium)
6.	Calcium
7.	Vitamin D
8.	Calcitonin (Calcitonin, Eel)
9.	Alkaline Phosphatase
10.	Ibandronic Acid (Boniva)

Related Therapies and Procedures

1.	Therapeutics
2.	Intravenous Infusions
3.	Drug Therapy (Chemotherapy)
4.	Duration of Therapy
5.	Radiotherapy