CRISPR-Associated Protein 9

An RNA-guided endodeoxyribonuclease that associates with CRISPR SEQUENCES in STREPTOCOCCUS PYOGENES and other bacteria where it participates in an adaptive immune function to cleave foreign DNA complimentary to small GUIDE RNA (sgRNAs). Structurally, Cas9 consists of an ALPHA-HELIX module and a nuclease module connected by a single helix. The nuclease module contains two enzymatic domains: RuvC, which cleaves non-target DNA strand, and an HNH nuclease domain, which cleaves the target strand. Specificity for the DNA target depends on the presence of a protospacer adjacent motif (PAM) sequence, a 2-6 nucleotide DNA sequence immediately following the sequence targeted by Cas9.

Also Known As:

Networked: 142 relevant articles (8 outcomes, 17 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Sato, Masahiro: 2 articles (04/2022 - 08/2020)
2.	Bier, Ethan: 2 articles (01/2022 - 12/2015)
3.	Gantz, Valentino M: 2 articles (01/2022 - 12/2015)
4.	Cheng, Du: 2 articles (10/2021 - 01/2021)
5.	Allen, Alexander G: 2 articles (01/2021 - 01/2020)
6.	Atkins, Andrew J: 2 articles (01/2021 - 01/2020)
7.	Dampier, Will: 2 articles (01/2021 - 01/2020)
8.	Li, Mingqiang: 2 articles (01/2021 - 01/2021)
9.	Nonnemacher, Michael R: 2 articles (01/2021 - 01/2020)
10.	Tao, Yu: 2 articles (01/2021 - 01/2021)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "The recent advent of clustered regularly interspaced short palindromic repeats (CRISPR)-CRISPR-associated protein 9 (Cas9)-based technology and its application in cancer genomics has, however, allowed the generation of a wealth of knowledge that has helped decipher several critical questions associated with translational cancer research. " 01/01/2021 - "The introduction of clustered regularly interspaced palindromic repeats (CRISPR)-associated protein 9 (Cas9) and microengineered miniorganoid technologies into liver organoids for cancer study has significantly accelerated these investigations. " 10/01/2018 - "Clustered regularly interspaced short palindromic repeats (CRISPR) associated protein 9 (Cas9) technology has been applied in varied biological studies, including cancer studies. " 12/22/2022 - "The clustered regularly interspaced short palindromic repeat (CRISPR)/CRISPR-associated protein 9 system can be used to knockdown tumor immunosuppression-related genes. " 09/07/2022 - "The Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-associated protein 9 (Cas9) system has recently emerged as a strong tool for gene therapy for both cancer as well as CAD treatment due to its great accuracy and efficiency. "
2.	Inborn Genetic Diseases (Disease, Hereditary) 12/13/2020 - "CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9)-mediated genome editing holds remarkable promise for the treatment of human genetic diseases. " 01/01/2023 - "Since its discovery as a genome editing tool, the clustered regularly interspaced short palindromic repeats and CRISPR-associated protein 9 (CRISPR/Cas9) system has opened new horizons in the diagnosis, research, and treatment of genetic diseases. " 01/01/2023 - "Clustered regularly interspaced short palindromic repeats/CRISPR-associated protein 9 (CRISPR/Cas9) system is a flexible and efficient genome engineering technology widely used for researches and therapeutic applications which offers immense opportunity to treat genetic diseases. " 02/01/2021 - "The CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats)/Cas9 (CRISPR-associated protein 9) system enables scientists to edit diverse genome types with relative ease, with the aim - in the near future - to prevent future human beings from developing genetic diseases. " 10/01/2020 - "CRISPR (clustered, regularly interspaced, short palindromic repeats)/CRISPR-associated protein 9 (Cas9) system has emerged as a powerful genome-editing tool to correct genetic disorders. "
3.	Atherosclerosis 05/01/2023 - "Today, new methods have been developed to treat or modify the natural course of cardiovascular diseases (CVDs), including atherosclerosis, by the clustered regularly interspaced short palindromic repeats-CRISPR-associated protein 9 (CRISPR-Cas9) system. " 10/10/2018 - "To establish an improved large animal model of familial hypercholesterolemia and atherosclerosis, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 system (CRISPR/Cas9) was used to disrupt the ApoE gene in Bama miniature pigs. "
4.	HIV Infections (HIV Infection) 01/01/2020 - "A cure strategy for HIV-1 has eluded scientists, but gene editing technologies such as clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) offer a new approach to developing a cure for HIV infection. "
5.	Hyperlipoproteinemia Type II (Familial Hypercholesterolemia) 10/10/2018 - "To establish an improved large animal model of familial hypercholesterolemia and atherosclerosis, the clustered regularly interspaced short palindromic repeats (CRISPR)-associated protein 9 system (CRISPR/Cas9) was used to disrupt the ApoE gene in Bama miniature pigs. "

Related Drugs and Biologics

1.	Apolipoproteins E (ApoE)
2.	RNA (Ribonucleic Acid)
3.	CRISPR-Cas Systems Guide RNA
4.	DNA (Deoxyribonucleic Acid)
5.	Transcription Activator-Like Effector Nucleases
6.	Small Interfering RNA (siRNA)
7.	Zinc Finger Nucleases
8.	GTP Phosphohydrolases (GTPases)
9.	Hematoxylin (Haematoxylon)
10.	Eosine Yellowish-(YS) (Eosin)

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Transplantation
4.	Lab-On-A-Chip Devices
5.	Spinal Injections