Transcription Activator-Like Effector Nucleases

Artificial nucleases that cleave DNA at a defined distance from specific DNA sequences recognized by TRANSCRIPTION ACTIVATOR-LIKE EFFECTORS. They are composed of an endodeoxyribonuclease fused to DNA-binding domains of the transcription activator-like effectors.

Also Known As:

Networked: 205 relevant articles (11 outcomes, 24 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Cathomen, Toni: 7 articles (01/2021 - 11/2015)
2.	Mussolino, Claudio: 5 articles (01/2021 - 11/2017)
3.	Sakuma, Tetsushi: 5 articles (01/2018 - 01/2014)
4.	Yamamoto, Takashi: 5 articles (01/2018 - 01/2014)
5.	Deng, Sihao: 4 articles (12/2020 - 06/2014)
6.	Li, Zhiyuan: 4 articles (12/2020 - 06/2014)
7.	Voytas, Daniel F: 4 articles (01/2018 - 10/2012)
8.	Joung, J Keith: 4 articles (11/2015 - 05/2012)
9.	Arimura, Shin-Ichi: 3 articles (01/2022 - 01/2019)
10.	Cornu, Tatjana I: 3 articles (01/2021 - 11/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/17/2023 - "Due to advance in genetics and novel molecular techniques such as CRISPR, TALEN these genes can be edited in such a way that their original function could be replaced which in turn improved the treatment possibilities and can be used against malignancies and even cure cancer in future along with CAR T cell therapy due to the specific recognition and attacking of tumor." 01/01/2015 - "TALEN-mediated targeting of HPV oncogenes ameliorates HPV-related cervical malignancy." 08/15/2017 - "In this study, we developed somatically mutated tumor models using TALEN-mediated somatic gene inactivation of cdkn2a/b or rb1 tumor suppressor genes in zebrafish. " 05/09/2014 - "We believe that TALENs will greatly facilitate the functional study of somatic mutations in MM as well as other cancers. " 10/20/2023 - "To the best of our knowledge, these results are the first to successfully detect an alteration in chemosensitivity to DOX in solid tumor cells and ascetic tumor cells derived from tumor of FVB/N-Trp53tm1Hw1 mice TALEN-mediated Trp53 mutant gene."
2.	Infections 02/01/2017 - "TALEN-Mediated Knockout of CCR5 Confers Protection Against Infection of Human Immunodeficiency Virus." 12/15/2016 - "In this study, we generated Rac2-deficient zebrafish using transcription activator-like effector nucleases to directly compare the role of Rac2 in vivo in neutrophils and macrophages in motility and the response to infection. " 01/01/2021 - "Preclinical Evaluation of a Novel TALEN Targeting CCR5 Confirms Efficacy and Safety in Conferring Resistance to HIV-1 Infection." 01/01/2020 - "Here, we studied the infection phenotypes of TALEN- and TILLING-derived Tamlo plants to the two hemibiotrophic pathogens Zymoseptoria tritici, causing Septoria leaf blotch in wheat, and Magnaporthe oryzae pv. Triticum (MoT), the causal agent of wheat blast disease. " 01/01/2018 - "TALENs-mediated homozygous CCR5Δ32 mutations endow CD4+ U87 cells with resistance against HIV‑1 infection."
3.	Tetraploidy 06/20/2015 - "Here we present a successful pipeline for site-directed mutagenesis in tetraploid potato through transient TALEN expression in protoplasts. " 06/20/2015 - "Targeted gene mutation in tetraploid potato through transient TALEN expression in protoplasts." 09/15/2014 - "We hypothesized that hepatocyte polyploidy might be protective against TALEN-induced loss of heterozygosity, and indeed Apc gene editing was less efficient in tetraploid than in diploid hepatocytes. " 06/25/2020 - "Targeted genome editing in tetraploid potato through transient TALEN expression by Agrobacterium infection." 01/01/2018 - "In potato, traits such as improved resistance to cold-induced sweetening, processing efficiency, herbicide tolerance, modified starch quality and self-incompatibility have been targeted utilizing CRISPR/Cas9 and TALEN reagents in diploid and tetraploid clones. "
4.	Inborn Genetic Diseases (Disease, Hereditary) 01/01/2023 - "However, due to challenges such as immune reactions and inability to target cells effectively in these applications, advanced molecular methods have been adopted in ZFN, TALEN, and CRISPR/Cas genome editing nucleases, which allow modular designs in stem cell-based genetic diseases' therapeutic approaches. " 10/01/2016 - "Targeted gene-editing technologies using engineered nucleases such as ZFN, TALEN, and/or CRISPR/Cas9 RGEN show great clinical promise, allowing for the site-specific correction of disease-causing mutations-a process with important applications in autosomal dominant or dominant-negative genetic disorders. " 01/01/2014 - "In addition, since genome editing has recently emerged as a potential therapeutic approach to cure genetic diseases, the definition of the most efficient TALEN pair could be an important step towards setting up a platform to perform genome editing in CNSI. " 01/01/2013 - "The capability to quickly and efficiently alter genes using TALENs promises to have profound impacts on biological research and to yield potential therapeutic strategies for genetic diseases." 05/01/2014 - "Our study demonstrates an important first step of using TALENs for the treatment of genetic diseases such as SCD, which represents a significant advance toward hiPSC-based cell and gene therapies."
5.	Hepatocellular Carcinoma (Hepatoma) 04/11/2016 - "To address this, TALENs-directed knockout of Nrf1α, but not Nrf1β/γ, is created in the human hepatocellular carcinoma (HepG2) cells. " 04/11/2016 - "TALENs-directed knockout of the full-length transcription factor Nrf1α that represses malignant behaviour of human hepatocellular carcinoma (HepG2) cells." 09/29/2017 - "Effect of TALEN-mediated IL-6 knockout on cell proliferation, apoptosis, invasion and anti-cancer therapy in hepatocellular carcinoma (HCC-LM3) cells." 12/07/2016 - "In this study, we utilize a gene editing tool, transcription activator-like effector nucleases (TALENs), to generate human hepatoma cells with a stable genetic deletion of APOB to assess of apoB in HCV. " 12/07/2016 - "Using the JFH-1 fully infectious cell-culture competent virus in Huh 7 hepatoma cells with TALEN-mediated gene deletion of apoB (APOB KO), we found a significant reduction in HCV RNA and protein levels following infection. "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Transcription Activator-Like Effector Nucleases
3.	Zinc Finger Nucleases
4.	Transcription Activator-Like Effectors
5.	RNA (Ribonucleic Acid)
6.	Apolipoproteins B (ApoB)
7.	Mitochondrial DNA (mtDNA)
8.	Starch (Cornstarch)
9.	Indicators and Reagents (Reagents)
10.	Herbicides

Related Therapies and Procedures

1.	Therapeutics
2.	Immunotherapy
3.	Heterologous Transplantation (Xenotransplantation)
4.	Autologous Transplantation