Heat Shock Transcription Factors

Heat and cold stress-inducible, transcription factors that bind to inverted 5'-NGAAN-3' pentamer DNA sequences and are regulated by POLY-ADP-RIBOSYLATION. They play essential roles as transcriptional activators of the HEAT-SHOCK RESPONSE by inducing expression of large classes of MOLECULAR CHAPERONES and heat-shock proteins. They also function in DNA REPAIR; transcriptional reactivation of latent HIV-1; and pre-mRNA processing and nuclear export of HSP70 HEAT-SHOCK PROTEINS during heat stress.

Also Known As:

Networked: 173 relevant articles (6 outcomes, 16 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Thiele, Dennis J: 6 articles (12/2020 - 02/2004)
2.	Nakai, Akira: 6 articles (01/2013 - 12/2003)
3.	Zou, Yunzeng: 5 articles (01/2018 - 12/2003)
4.	Li, Maojuan: 4 articles (02/2021 - 01/2020)
5.	Miao, Yinglei: 4 articles (02/2021 - 01/2020)
6.	Niu, Junkun: 4 articles (02/2021 - 01/2020)
7.	Wang, Kunhua: 4 articles (02/2021 - 01/2020)
8.	Wang, Wen: 4 articles (02/2021 - 01/2020)
9.	Wu, Jing: 4 articles (02/2021 - 01/2020)
10.	Zhang, Fengrui: 4 articles (02/2021 - 01/2020)

Related Diseases

1.	Neoplasms (Cancer) 05/21/2012 - "Our previous study showed that heat shock transcription factor 1 (HSF1) overexpression could increase the anti-tumor efficacy of E1B55kD deleted oncolytic adenovirus through increasing the viral burst. " 01/01/2019 - "Recently, heat shock transcription factor 1 (HSF1) is observed to be involved in the process of cellular metabolism in cancer. " 12/20/2016 - "Heat shock transcription factor 1 (HSF1), a key regulator of the heat-shock response, is deregulated in many cancers. " 02/01/2016 - "Heat-shock transcription factor (HSF) family members function in stress protection and in human diseases including proteopathies, neurodegeneration and cancer. " 02/01/2015 - "Heat shock transcription factor 1 (HSF1), the major regulator of stress response, is frequently activated in cancer and has an apparent role in malignant transformation. "
2.	Cardiomegaly (Heart Hypertrophy) 11/01/2011 - "Heat shock transcription factor 1 (HSF1) plays an important role not only in excise-induced cardiac hypertrophy but also in protection against pressure overload-induced cardiac dysfunction. " 01/01/2018 - "Here, we have been suggested that heat-shock transcription factor 1 (HSF1) is a novel repressor of ischaemia-induced cardiac hypertrophy. " 01/01/2018 - "Heat-shock transcription factor 1 is critically involved in the ischaemia-induced cardiac hypertrophy via JAK2/STAT3 pathway." 02/16/2007 - "Adaptive and maladaptive cardiac hypertrophy: what is the effective role of heat shock transcription factor 1?" 12/08/2006 - "Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy."
3.	Ischemia 08/01/1996 - "We further find that, contrary to some earlier reports, simulated ischemia activates the heat shock transcription factor (HSF) rapidly, as is the case for heat shock." 05/01/1992 - "Molecular signals for the activation of heat shock transcription factor during ischemia." 01/01/2019 - "Heat shock transcription factor 1 (HSF1), a stress-responsive protein, has been shown to be important in response to cellular stress stimuli, including ischemia. " 11/01/1996 - "We examined the DNA-binding activity of heat shock transcription factor (HSF), by which the transcription of heat shock genes is mainly regulated, during heat shock or ischemia/reperfusion in isolated rat heart. " 10/01/2006 - "In this study, we examined insulin- and heat shock-treated hearts for improved contractile recovery after 30 min of ischemia, activation of the heat shock transcription factor, and localization of the Hsp70 in relation to dystrophin and alpha-tubulin. "
4.	Shock 02/03/2006 - "Studies have indicated the role of HSF1 (heat-shock transcription factor 1) in repressing the transcription of some nonheat shock genes. " 04/05/2002 - "Heat shock factor (HSF) 1 is the major heat shock transcription factor that regulates stress-inducible synthesis of heat shock proteins and is also essential in protection against endotoxic shock. " 11/01/2009 - "Deficit of heat shock transcription factor 1-heat shock 70 kDa protein 1A axis determines the cell death vulnerability in a model of spinocerebellar ataxia type 6."
5.	Acute Lung Injury 11/01/2022 - "[Protective effect of heat shock transcription factor 1 on acute lung injury in septic rats by regulating NOD-like receptor protein 3 inflammasome activation]." 11/01/2022 - "To determine whether heat shock transcription factor 1 (HSF1) ameliorates sepsis induced acute lung injury (ALI) by regulating NOD-like receptor protein 3 (NLRP3) inflammasome activity in rat alveolar macrophages (AM). "

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Heat-Shock Proteins (Heat-Shock Protein)
3.	Dystrophin
4.	Tubulin
5.	Insulin (Novolin)
6.	Transcription Factors (Transcription Factor)
7.	Inflammasomes
8.	Phosphoric Monoester Hydrolases (Phosphatases)
9.	ethylene
10.	S-Adenosylmethionine (Ademetionine)

Related Therapies and Procedures

1.	Therapeutics
2.	Rewarming