Heterogeneous Nuclear Ribonucleoprotein A1

A heterogeneous ribonucleoprotein that contains an RNA-BINDING MOTIF and has poly(ADP)ribose-binding capability. It functions in the packaging of pre-mRNA into hnRNP particles for export to the cytoplasm and may play a role in RNA SPLICING site selection.

Also Known As:

Networked: 155 relevant articles (1 outcomes, 13 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Levin, Michael C: 9 articles (01/2022 - 01/2012)
2.	Salapa, Hannah E: 8 articles (01/2022 - 01/2016)
3.	Lee, Sangmin: 5 articles (01/2020 - 01/2012)
4.	Hutchinson, Catherine: 4 articles (01/2022 - 11/2018)
5.	Schwartz, Stefan: 4 articles (01/2020 - 10/2004)
6.	Thibault, Patricia A: 3 articles (01/2022 - 01/2021)
7.	Douglas, Joshua N: 3 articles (04/2016 - 01/2012)
8.	Gardner, Lidia A: 3 articles (04/2016 - 01/2012)
9.	Hammond, S Austin: 2 articles (01/2022 - 11/2021)
10.	Libner, Cole D: 2 articles (01/2022 - 01/2020)

Related Diseases

1.	Enteritis 07/01/2015 - "This study investigated the function of hnRNP A1 in mice enteritis models. " 07/01/2015 - "hnRNP A1 improves intestinal injury in anti-CD3 antibody-induced enteritis mice through the upregulation of TFF2, which regulates apoptosis and enhances epithelial restoration, whereas this molecule ameliorates DSS-induced colitis through a different pathway." 07/01/2015 - "According to the microarray analysis, trefoil factor 2 (TFF2) was identified as a candidate molecule targeted by hnRNP A1 in the anti-CD3 antibody-induced enteritis group. " 07/01/2015 - "Heterogeneous Nuclear Ribonucleoprotein A1 Improves the Intestinal Injury by Regulating Apoptosis Through Trefoil Factor 2 in Mice with Anti-CD3-induced Enteritis." 07/01/2015 - "Moreover, the binding between hnRNP A1 and TFF2 mRNA significantly increased in the enteritis mice, and the administration of siRNA against either hnRNP A1 or TFF2 exacerbated the degree of intestinal injury. "
2.	Colitis 07/01/2015 - "hnRNP A1 improves intestinal injury in anti-CD3 antibody-induced enteritis mice through the upregulation of TFF2, which regulates apoptosis and enhances epithelial restoration, whereas this molecule ameliorates DSS-induced colitis through a different pathway." 07/01/2015 - "In the DSS-induced colitis group, treatment with the siRNA of hnRNP A1 worsened the intestinal injury, while the expression of TFF3 did not change. "
3.	Neoplasms (Cancer) 05/15/2019 - "Previous study has shown heterogeneous nuclear ribonucleoprotein A1(HNRNPA1) is highly expressed in various human cancers. " 12/17/2023 - "Our results underscore the significance of the miR-195-5p/hnRNP A1 axis in regulating the migratory potential of cancer cells and its role in promoting HCC by orchestrating cell migration processes." 01/01/2023 - "Heterogeneous Nuclear ribonucleoprotein A1 (hnRNPA1) has recently been found to be involved in the progression of several types of cancer, but its role in HCC remains uncovered. " 01/01/2023 - "Here, we will report the recent advancements in our knowledge of the role of hnRNP A1 in the biological processes underlying cancer proliferation and growth, with a particular focus on metabolic reprogramming." 09/06/2022 - "High expression of HNRNP A1 can promote the proliferation, migration, and invasion in HCC cells and accelerate tumor progression in mice. "
4.	Carcinogenesis 12/01/2016 - "hnRNP A1 overexpression promotes cell transformation and tumorigenesis in a SIRT1-dependent manner. " 03/29/2016 - "In this work, we examined if hnRNP A1 and A2 could regulate the alternative splicing of Tid1 to modulate tumorigenesis in NSCLC. " 05/23/2021 - "Thus, our study unveils a novel role of HNRNP A1 in lung carcinogenesis via post-transcriptional regulation of VRK1 expression and suggests its potential as a therapeutic target for patients with lung cancer." 03/01/2005 - "In the present study, we conducted genetic and expression analysis of the hnRNP A1 gene in sporadic human colorectal cancers to clarify its possible involvement in human carcinogenesis. " 01/01/2021 - "Mechanistically, SAM68 increased the binding of the splicing repressor hnRNP A1 to exon 9 of PKM, thereby enhancing PKM2 isoform formation and PKM2-dependent aerobic glycolysis and tumorigenesis. "
5.	Neurodegenerative Diseases (Neurodegenerative Disease) 11/01/2021 - "Its importance in neuronal functioning is underscored from the study of its pathogenic features in many neurodegenerative diseases where neuronal hnRNP A1 is mislocalized from the nucleus to the cytoplasm resulting in loss of hnRNP A1 function. " 11/01/2021 - "In summary, these findings indicate that hnRNP A1 loss-of-function contributes to neuronal dysfunction and cell death and implicates hnRNP A1 dysfunction in the pathogenesis of neurodegenerative diseases." 05/23/2021 - "In recent years, it has become more evident that HNRNP A1 contributes to the development of neurodegenerative diseases. " 01/01/2021 - "With this knowledge, the review then describes the influence of hnRNP A1 in neurodegenerative disease, and how its dysfunction may contribute the pathogenesis." 01/01/2021 - "A Comprehensive Analysis of the Role of hnRNP A1 Function and Dysfunction in the Pathogenesis of Neurodegenerative Disease."

Related Drugs and Biologics

1.	Proteins (Proteins, Gene)
2.	Heterogeneous Nuclear Ribonucleoprotein A1
3.	RNA (Ribonucleic Acid)
4.	Phosphotransferases (Kinase)
5.	Arginine (L-Arginine)
6.	Fragile X Mental Retardation Protein
7.	Eukaryotic Initiation Factor-4E
8.	Telomerase (Telomerase Reverse Transcriptase)
9.	PTB-Associated Splicing Factor
10.	RNA-Binding Proteins (RNA-Binding Protein)

Related Therapies and Procedures

1.	Therapeutics
2.	Transcutaneous Electric Nerve Stimulation (TENS)
3.	Castration