The microRNA-195-5p/hnRNP A1 axis contributes to the progression of hepatocellular carcinoma by regulating the migration of cancer cells.

Abstract

Dysregulation of gene expression is critical for the progression of cancer. The augmented expression of hnRNP A1 in patients with hepatocellular carcinoma (HCC) has been related to its oncogenic functions. However, the underlying mechanisms responsible for upregulation of hnRNP A1 have not been fully elucidated. In the present study, we identified microRNA-195-5p (miR-195-5p), a miRNA downregulated in HCC, as a novel regulator governing hnRNP A1 expression. Notably, our investigations showed an inverse correlation between hnRNP A1 level, which was increased in HCC, and miR-195-5p level, which was decreased. Our findings demonstrated that hnRNP A1 significantly enhanced the migration and invasion of PLC/PRF/5 cells through its association with mRNAs regulating metastasis. MiR-195-5p also interfered with the hnRNP A1-mediated cell migration by targeting hnRNP A1. Our results underscore the significance of the miR-195-5p/hnRNP A1 axis in regulating the migratory potential of cancer cells and its role in promoting HCC by orchestrating cell migration processes.

• Authors: Myeongwoo Jung, Eunbyul Ji, Hoin Kang, Chongtae Kim, Seungyeon Ryu, Sukyoung Han, Seongho Cha, Eun Kyung Lee
• Journal: Biochemical and biophysical research communications (Biochem Biophys Res Commun) Vol. 686 Pg. 149183 (Dec 17 2023) ISSN: 1090-2104 [Electronic] United States
• PMID: 37926044 (Publication Type: Journal Article)
• Copyright: Copyright © 2023 Elsevier Inc. All rights reserved.

Chemical References

• Heterogeneous Nuclear Ribonucleoprotein A1
• MicroRNAs
• MIRN195 microRNA, human

Topics

• Humans
• Carcinoma, Hepatocellular (pathology)
• Heterogeneous Nuclear Ribonucleoprotein A1 (genetics, metabolism)
• Liver Neoplasms (pathology)
• Cell Proliferation (genetics)
• MicroRNAs (genetics, metabolism)
• Cell Line, Tumor
• Cell Movement (genetics)
• Gene Expression Regulation, Neoplastic