Baculoviral IAP Repeat-Containing 3 Protein

A regulator of APOPTOSIS that functions as an E3 ubiquitin protein ligase. It contains three baculoviral IAP repeats in its N-terminal half, a CARD DOMAIN, and a RING finger domain at its C-terminus. It is highly expressed in fetal lung and kidney, and adult lymphoid tissues such as spleen, thymus, and peripheral blood lymphocytes. It functions in INFLAMMATION signaling, the INNATE IMMUNE RESPONSE, cell growth and proliferation, and metastasis of tumor cells.

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Networked: 53 relevant articles (2 outcomes, 4 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Seto, Masao: 4 articles (12/2005 - 11/2003)
2.	Hosokawa, Yoshitaka: 3 articles (12/2005 - 11/2003)
3.	Tsuzuki, Shinobu: 3 articles (12/2005 - 11/2003)
4.	Asaka, Masahiro: 2 articles (12/2005 - 11/2003)
5.	Izumiyama, Koh: 2 articles (12/2005 - 11/2003)
6.	Nakagawa, Masao: 2 articles (12/2005 - 11/2003)
7.	Suzuki, Ritsuro: 2 articles (12/2005 - 11/2003)
8.	Yonezumi, Masakatsu: 2 articles (12/2005 - 11/2003)
9.	Li, Hui: 2 articles (06/2004 - 12/2003)
10.	Suzuki, Hiroko: 2 articles (05/2004 - 11/2003)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2017 - "Further, BIRC3 protein was highly expressed in the tumor cell niches compared to the perivascular niche across multiple regions in GBM patient tissue microarrays. " 02/15/2016 - "There was consistent downregulation of cellular inhibitor of apoptosis protein 1 in tumors (P = .016) and PBMCs (P < .01). " 10/24/2023 - "Interestingly, in the p62/NBR1 liquid droplet, degradation of RAS-related C3 botulinum toxin substrate 1 was accelerated by cellular inhibitor of apoptosis protein 1, which limits cancer cell motility. " 04/07/2020 - "The spectrum of CDK6-specific PROTACs was extended to von Hippel Lindau (VHL) and cellular inhibitor of apoptosis protein 1 (cIAP1) that are essential for most cancer cells and therefore less likely to be inactivated. " 04/18/2014 - "Cellular inhibitor of apoptosis protein 1 and 2 (cIAP1/2) and X-linked inhibitor of apoptosis protein (XIAP) are key apoptosis regulators and promising new cancer therapeutic targets. "
2.	B-Cell Lymphoma (Lymphoma, B Cell) 12/15/2005 - "MALT1, BCL10 (B-cell lymphoma 10), and API2 (apoptosis inhibitor 2)-MALT1 are key molecules in mucosa-associated lymphoid tissue (MALT) lymphomagenesis. " 10/01/2007 - "With respect to SAHA, OSU-HDAC42 exhibited greater apoptogenic potency, which was associated with reduced levels of the apoptotic regulators phosphorylated Akt B-cell lymphoma-xL, survivin, cellular inhibitor of apoptosis protein 1, and cellular inhibitor of apoptosis protein 2. The in vivo efficacy of OSU-HDAC42 versus SAHA was assessed in orthotopic and subcutaneous xenograft tumor models in athymic nude mice. " 11/01/2005 - "By using reverse transcription-polymerase chain reaction analysis, the expression levels of mRNA of CARMA1, CARD9, Bcl10, and the apoptosis inhibitor 2 (API2)-MALT1 chimeric transcript were determined in tissue specimens from 65 patients with primary gastric B-cell lymphoma (43 patients with low-grade MALT lymphoma, 16 patients with MALT lymphoma plus diffuse large B-cell lymphoma [DLBL], and 6 patients with DLBL without MALT lymphoma) and in tissue specimens from 18 patients with chronic gastritis. " 12/01/2014 - "In the present study, we reported that celastrol potentiated tumor necrosis factor-α (TNF-α)-induced apoptosis, affected activation of caspase-8, caspase-3 and PARP cleavage, and inhibited the expression of anti-apoptotic proteins such as cellular inhibitor of apoptosis protein 1 and 2 (cIAP1 and cIAP2), cellular FLICE-inhibitory protein (FLIP), and B-cell lymphoma 2 (Bcl-2). " 10/01/2014 - "Escin induced apoptosis in a time-dependent manner, which was accompanied by increases in pro-apoptotic (BCL-2 associated X protein, cleaved-caspase3, and cleaved-poly [adenosine diphosphate-ribose] polymerase) proteins and decreases in antiapoptotic (X-linked inhibitor of apoptosis protein, cellular inhibitor of apoptosis protein-1, cellular inhibitor of apoptosis protein-2B-cell leukemia/lymphoma-2, and B-cell lymphoma-extra large) proteins. "
3.	Ataxia Telangiectasia (Louis Bar Syndrome) 01/01/2019 - "Among the differentially expressed proteins, we identified that serine-protein kinase ataxia telangiectasia mutated (ATM) and its downstream target, cellular inhibitor of apoptosis protein 1 (c-IAP1), were up-regulated by E2. " 09/01/2010 - "In addition, an expressive enhancement in mRNA levels of p73, cyclin-dependent kinase inhibitor 1A (p21), tumor protein 53-induced nuclear protein 1 (TP53INP1), WNK lysine deficient protein kinase 2 (WNK2) and lipocalin 2 coupled with a significant reduction in transcriptional levels of NF-kappaB inhibitor beta (IKK2), Nemo, BCL2-like 1 (BCL-X(L)), inhibitor of apoptosis protein 1 (cIAP2), X-linked inhibitor of apoptosis protein (XIAP), survivin, Bcl-2, TIP60, ataxia telangiectasia (ATM), SHP-2 and sirtuin (SIRT1) were observed. "
4.	Infections 01/01/2017 - "The Culicoides sonorensis inhibitor of apoptosis 1 protein protects mammalian cells from apoptosis induced by infection with African horse sickness virus and bluetongue virus." 01/01/2014 - "Drosophila inhibitor of apoptosis protein 1 (DIAP1), which is related to caspase-dependent apoptosis, was also significantly upregulated after infection. " 05/01/2009 - "The levels of cIAP2 protein (+/-SD) in infected cells were 3.5 +/- 1.7 -fold and 2.3 +/- 1.2 -fold higher than that in uninfected control cells at 24 and 48 h after infection. " 04/08/2008 - "In this study, we demonstrate that the induction of ER stress by MCF13 MLV infection results in an increase in the phosphorylation of the alpha-subunit of eukaryotic initiation factor 2. In cells in which this occurs, we have detected an up-regulation of the cellular inhibitor of apoptosis protein 1 (c-IAP1). " 10/01/2019 - "Finally, we investigated the clinical relevance of Fn infection, BIRC3 protein expression and chemoresistance to 5-Fu treatment in CRC patients. "
5.	Marginal Zone B-Cell Lymphoma (MALT Lymphoma) 07/01/2005 - "t(11 ; 18)(q21 ; q21) is a specific chromosomal aberration in mucosa-associated lymphoid tissue (MALT) lymphoma, and produces chimeric transcript Apoptosis Inhibitor 2 (API2)-MALT1. " 11/06/2003 - "t(11; 18) (q21; q21) is a chromosomal aberration specific to low-grade mucosa-associated lymphoid tissue (MALT) lymphoma, and generates the chimeric product apoptosis inhibitor 2 (API2)-MALT1, which has been suggested to play an important role in MALT lymphomagenesis. " 12/01/2001 - "t(11;18)(q21;q21) has been recognized as a characteristic chromosomal translocation in mucosa-associated lymphoid tissue (MALT)-type lymphoma, and recent studies have demonstrated that this translocation results in the chimaeric transcript of API2 (apoptosis inhibitor 2)-MALT1 (mucosa-associated lymphoid tissue lymphoma translocation gene 1). " 11/01/2005 - "By using reverse transcription-polymerase chain reaction analysis, the expression levels of mRNA of CARMA1, CARD9, Bcl10, and the apoptosis inhibitor 2 (API2)-MALT1 chimeric transcript were determined in tissue specimens from 65 patients with primary gastric B-cell lymphoma (43 patients with low-grade MALT lymphoma, 16 patients with MALT lymphoma plus diffuse large B-cell lymphoma [DLBL], and 6 patients with DLBL without MALT lymphoma) and in tissue specimens from 18 patients with chronic gastritis. "

Related Drugs and Biologics

1.	Survivin
2.	Proteins (Proteins, Gene)
3.	Inhibitor of Apoptosis Proteins
4.	Messenger RNA (mRNA)
5.	X-Linked Inhibitor of Apoptosis Protein
6.	NF-kappa B (NF-kB)
7.	Protein Kinases (Protein Kinase)
8.	Sirtuin 1
9.	Sirtuins
10.	Cyclin-Dependent Kinases (cdk Proteins)