Abstract | BACKGROUND: Although caspase recruitment domain (CARD) membrane-associated guanylate kinase (MAGUK) protein 1 (CARMA1) and CARD9 play important roles in lymphocyte activation, the significance of CARMA1 and CARD9 in the pathogenesis of gastric mucosa-associated lymphoid tissue ( MALT) lymphoma remains to be elucidated. METHODS: RESULTS: CARMA1 mRNA was detected in 55% of lymphoma patients but in only 17% of chronic gastritis patients. The positive rates for CARD9, Bcl10, and API2-MALT1 chimeric transcript in the lymphoma patients were 48%, 98%, and 8%, respectively, whereas the 3 molecules were not detected in any specimens from patients with chronic gastritis. The expression of CARMA1 and CARD9 was frequent in the Helicobacter pylori-negative patients (100% and 86%, respectively), in the API2-MALT1 chimeric transcript-positive patients (100% and 100%, respectively), and in the specimens from patients who did not respond to H. pylori eradication (76% and 71%, respectively). In addition, CARMA1 expression was positive more frequently in patients of DLBL without MALT lymphoma (100%) than in patients of MALT lymphoma (51%). CARMA1 protein expression was correlated significantly with the expression of CARMA1 mRNA and also with the expression of nuclear BCL10. CONCLUSIONS: The overexpression of CARMA1 and CARD9 presumably is associated with the development or progression of gastric B-cell lymphoma, especially among patients who have disease in which the pathogenesis is not related to H. pylori.
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Authors | Shigeo Nakamura, Shotaro Nakamura, Takayuki Matsumoto, Shinichiro Yada, Minako Hirahashi, Hiroshi Suekane, Takashi Yao, Kenichi Goda, Mitsuo Iida |
Journal | Cancer
(Cancer)
Vol. 104
Issue 9
Pg. 1885-93
(Nov 01 2005)
ISSN: 0008-543X [Print] United States |
PMID | 16177990
(Publication Type: Journal Article)
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Copyright | (c) 2005 American Cancer Society. |
Chemical References |
- API2-MALT1 fusion protein, human
- Adaptor Proteins, Signal Transducing
- Apoptosis Regulatory Proteins
- B-Cell CLL-Lymphoma 10 Protein
- BCL10 protein, human
- CARD Signaling Adaptor Proteins
- CARD9 protein, human
- Membrane Proteins
- Oncogene Proteins, Fusion
- RNA, Messenger
- CARD11 protein, human
- Guanylate Cyclase
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Topics |
- Adaptor Proteins, Signal Transducing
(metabolism)
- Adolescent
- Adult
- Aged
- Aged, 80 and over
- Apoptosis Regulatory Proteins
- B-Cell CLL-Lymphoma 10 Protein
- CARD Signaling Adaptor Proteins
- Female
- Gastritis
(metabolism)
- Guanylate Cyclase
(metabolism)
- Humans
- Immunohistochemistry
- Lymphoma, B-Cell, Marginal Zone
(etiology, metabolism)
- Male
- Membrane Proteins
(metabolism)
- Middle Aged
- Oncogene Proteins, Fusion
(metabolism)
- RNA, Messenger
(analysis)
- Reverse Transcriptase Polymerase Chain Reaction
- Stomach Neoplasms
(etiology, metabolism)
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